Nanometer dragon's blood capsule and its preparation method

A preparation process, the technology of dragon's blood, which is applied in capsule delivery, microcapsules, blood diseases, etc., can solve the problems of low bioavailability and low solubility, so as to reduce the dosage of medicine, improve bioavailability, and treat heart and brain Effects of Vascular Diseases

Inactive Publication Date: 2008-05-07
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES +1
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

Due to the low solubility in water, it is difficult for the drug to conduct in body fluids and enter the lesion with the blood, resulting in low bioavailability

Method used

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  • Nanometer dragon's blood capsule and its preparation method
  • Nanometer dragon's blood capsule and its preparation method
  • Nanometer dragon's blood capsule and its preparation method

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Embodiment Construction

[0016] The present invention utilizes the property that dragon's blood is soluble in ethanol but not in water, drips the ethanol solution of dragon's blood into the aqueous gelatin solution in which capsule material is dissolved, and wraps it immediately when it produces nascent microcrystals, and undergoes coagulation, condensation solidification, Steps such as separation obtain nanoscale microcapsules.

[0017] Drop the colloidal sample of dragon's blood jerky microcapsules on the sample sheet, vacuumize after natural air drying, plate a layer of gold on the sample, put it into a scanning electron microscope for observation, and observe that the capsule shape is as follows: figure 1 shown by figure 1 It can be seen that the capsule is round or oval, and the diameter of the capsule is less than 100nm. The Tyndall scattering phenomenon that occurs when the aqueous solution prepared by the nano dragon's blood capsule is irradiated with a laser pointer is shown in Figure-2, fro...

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Abstract

A Dragon's blood nano-capsule for treating cardiovascular and cerebrovascular diseases is prepared through preparing alcohol solution of Dragon's blood, dripping it in the aqueous solution of gelatin while stirring, educing out micro-crystals while wrapping them by gelatin, regulating pH value, coagulating, cooling to 0-5 deg.C, adding formaldehyde to solidify the shell, centrifugal separation, water washing, dewatering and grinding.

Description

technical field [0001] The invention relates to a dragon's blood jerky capsule and a preparation process. Background technique [0002] Resina Draconis is the ethanol extract of the resin of Dracaena cochinchinensis (Lour.) S.C. Chen of the Liliaceae genus Dracaena cochinchinensis (Lour.) S.C. Chen. through. It has the effects of promoting blood circulation, removing blood stasis, antibacterial and anti-inflammatory, and analgesic. It has good curative effect on bleeding diseases such as coronary heart disease, local trauma bleeding, gynecological uterine blood, upper gastrointestinal bleeding, hemorrhoids and epistaxis. The current dosage form is mainly for external use. Powder and hard capsule for oral administration. Due to the low solubility in water, it is difficult for the drug to conduct in body fluids and enter the lesion with the blood, resulting in low bioavailability. In order to change the dragon's blood medicine into a water-soluble medicine, someone proposed...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K36/896A61P7/04A61P9/00A61P29/00A61P31/04
Inventor 洪宗国邓小莲童惠娟
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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