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Nano-emulsion drug of triperygium wilfordii polycoride and preparation method thereof

A technology of tripterygium glycosides and nanoemulsions, which is applied in the field of medicine, can solve the problems of low bioavailability, and achieve the effects of improving compliance, facilitating absorption, and increasing absorption

Inactive Publication Date: 2008-08-20
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the deficiencies in the existing dosage forms, and propose a new nanoemulsion drug of tripterygium glycosides, which improves the solubility of tripterygium glycosides, overcomes the shortcoming of its low bioavailability, and reduces its toxicity. side effects, and, through transdermal administration to improve patient compliance, administration can be discontinued at any time, the preparation method is simple, and the production cost is low

Method used

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  • Nano-emulsion drug of triperygium wilfordii polycoride and preparation method thereof
  • Nano-emulsion drug of triperygium wilfordii polycoride and preparation method thereof
  • Nano-emulsion drug of triperygium wilfordii polycoride and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] 1) Weigh 0.01g of tripterygium glycosides, 1.80g of polyoxyethylene ether (40) hydrogenated castor oil, 0.20g of isooctyl palmitate, and 7.99g of distilled water, and set aside.

[0063] 2) 0.01g of tripterygium glycosides and 1.80g of polyoxyethylene ether (40) hydrogenated castor oil were mixed and dissolved, and 0.20g of isooctyl palmitate was added to completely dissolve tripterygium glycosides And as the oil phase.

[0064] 3) The said weight of distilled water is used as the water phase.

[0065] 4) Stir the oil phase at room temperature, and slowly add distilled water dropwise while stirring, until the system becomes a transparent liquid, that is, tripterygium glycosides nanoemulsion with a particle size of 10-100 nm is obtained.

Embodiment 2

[0067] 1) Weigh 0.18g of Tripterygium wilfordii, 2.88g of Tween-80, 0.48g of Span-80, 1.44g of paraffin oil, 0.20g of azone, and 7.10g of distilled water, and set aside.

[0068] 2) Mix 0.08 g of tripterygium glycosides and 2.88 g of Tween-80 and dissolve them, add 0.48 g of Span-80 and 1.44 g of paraffin oil to completely dissolve tripterygium glycosides and use them as an oil phase.

[0069] 3) The said weight of distilled water is used as the water phase.

[0070] 4) Stir the oil phase at room temperature, and slowly add distilled water dropwise while stirring, until the system becomes a transparent liquid, that is, tripterygium glycosides nanoemulsion with a particle size of 10-100 nm is obtained.

[0071] 5) Add the weight of the penetration enhancer azone into the system at room temperature

Embodiment 3

[0073] 1) Weigh 0.40 g of tripterygium glycosides, 10.00 g of polyoxyethylene ether (40) hydrogenated castor oil, 1.10 g of isopropyl myristate, and 21.90 g of distilled water, and set aside.

[0074] 2) Mix 0.40 g of tripterygium glycosides, polyoxyethylene ether (40) hydrogenated castor oil 10.00 g, and isopropyl myristate 1.10 g at room temperature to completely dissolve tripterygium glycosides and as the oil phase.

[0075] 3) The said weight of distilled water is used as the water phase.

[0076] 4) Stir the oil phase at room temperature, slowly add water dropwise while stirring, and keep stirring until the system becomes a transparent liquid. That is, tripterygium glycosides nanoemulsion with a particle diameter of 10-100 nm is obtained.

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Abstract

Disclosed is a Chinese medicament for treating rheumatoid arthritis which is prepared from Tripterygium wilfordii glucoside 0.10-2.00%, surface active agent 15.00-40.00%, auxiliary surface active agent 0.00-10.00%, oil 3.00-10.00%, penetration enhancer 0.00-5.00%, and distilled water 55.00-75.00%. The medicament can be prepared into emulsion with a grain size between 10-100nm, and has the functions of antiphlogistic, analgesic and immunosuppresive actions.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of tripterygium glycosides, an anti-rheumatoid arthritis drug with anti-inflammatory, analgesic and immunosuppressive effects, in particular to a tripterygium glycosides nanoemulsion drug and its preparation method. Background technique [0002] Rheumatoid arthritis (RA) is a multisystem inflammatory autoimmune disease involving peripheral joints. Symmetrical, chronic inflammatory lesions of multiple joints around are the characteristic symptoms of RA, and its clinical manifestations are pain, swelling, and functional decline in the affected joints, and the lesions are persistent and recurrent. The disease is distributed globally, and the age of onset is mostly between 25 and 55 years old. Female patients are 2 to 3 times that of male patients. The prevalence rate in my country is 0.32% to 0.36%. one of the main causes. [0003] Tripterygium Wilfird Hook (Triterygium Wil...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K36/37A61P19/04A61P37/06A61P29/00
Inventor 欧阳五庆何欣
Owner NORTHWEST A & F UNIV
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