Manufacturing technique for gingko leaf extracts
A production process and technology of ginkgo biloba, which is applied in the field of high-quality ginkgo leaf extract and production process, can solve the problems of unadjustable content and quality fluctuation, and achieve the effect of meeting the needs of fingerprints, improving protection and improving curative effect
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Embodiment 1
[0046] (1) production
[0047]600 kilograms of dried ginkgo leaves, 3 tons of 80% methanol, dynamic extraction twice, collecting the extract, vacuum concentration, water sinking, and standing overnight; the supernatant was centrifuged in a high-speed centrifuge at 10,000 rpm; water sinking The substance was extracted with ethyl acetate, and the crude lactone was collected; the centrifugate was passed through an ion exchange column (the ion exchange column was mixed with 50% macroporous resin HPD-600 and 50% amide resin), and the column on the centrifugate reached saturation Finally, wash off part of the impurities with a small amount of process water, and then elute with ethyl acetate. The eluate is concentrated and combined with the crude lactone extracted from the precipitate, and the rear part of the distilled water wash is discarded; then use acetone The flavonoid glycosides are eluted; the eluent is dried and waited for treatment; the content of the eluted crude flavonoid...
Embodiment 2
[0059] Implementation example 2 (35 / 12)
[0060] (1) production
[0061] 600 kilograms of ginkgo dry leaves, 3 tons of 60% acetone, dynamic extraction twice, collecting the extract, vacuum concentration, water sinking, and standing overnight; the supernatant was centrifuged in a high-speed centrifuge at 10,000 rpm; water sinking The substance was extracted with ethyl acetate, and the crude lactone was collected; the centrifugate was passed through an ion exchange column (the ion exchange column was mixed with 50% macroporous resin HPD-600 and 50% amide resin, and two precautions must be taken before loading the column. Mix the resins evenly, and then treat them with PH8 lye). After the centrifuge is saturated on the column, wash away some impurities with a small amount of water, and then use ethyl acetate to elute the lactone, and the extracted The crude lactones are combined; then the flavonoid glycosides are eluted with acetone; the eluent is dried for treatment; the conten...
Embodiment 3
[0073] Example 3 (39 / 14)
[0074] (1) production
[0075] Commercially available Ginkgo biloba crude extract (Ginkgo flavonoid content ≤ 24% / lactone ≤ 6%) 25 kg, 500 kg of 80% methanol, heated at 60 ° C, stirred until completely dissolved, and left standing at room temperature for 4 hours; Centrifuge in a centrifuge; the centrate passes through the ion exchange column (the ion exchange column is composed of 50% macroporous resin HPD-600, mixed with 50% amide resin), and after the centrate is saturated on the column, wash it off with a small amount of water Part of the impurities, and then eluted with ethyl acetate to collect the lactone; then elute the flavonoid glycoside with acetone; dry the eluate and wait for treatment; The dry powder content is around 48%. The crude flavone glycosides and crude lactones are respectively refined once with an organic solvent to obtain 45%-55% of flavone glycoside dry powder and 55%-65% of lactone dry powder. According to the percentage r...
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