Ginger extract and its preparing method and application
A ginger extract, the only technology, applied in the field of ginger extract, its preparation and application, can solve the problems of small drug loading in dripping pills, not suitable for making dripping pills, etc., to reduce the deposition of collagen fibers and the formation of false leaflets , liver protection and anti-hepatic fibrosis
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Embodiment 1
[0034] Embodiment one: the preparation of ginger extract
[0035] Supercritical CO 2 Fluid (SFE-CO 2 ) extraction process is as follows:
[0036] CO 2 Steel cylinder→freezing system→high pressure pump→extraction kettle→desorption kettle I→desorption kettle II→circulation.
[0037] The extraction parameters are: the pressure of the extraction kettle is 24mpa, the temperature is 42°C, the pressure of the analysis kettle I is 12.4mpa, and the temperature is 60°C, the pressure of the analysis kettle II is 6.5mpa, the temperature is 40°C, the CO 2 The flow rate is 10kg / h.kg raw material, and the time is 4-6 hours.
[0038] Ginger, a traditional Chinese medicinal material, is crushed and sieved, with a particle size of 30-50 mesh. Weigh 10 kg and put it into the extraction kettle. After 4-6 hours of extraction, the material is discharged from the analysis kettle I and the analysis kettle II, and it is 180 g of light yellow ginger oil. It has a strong natural aroma and spicy tas...
Embodiment 2
[0041] Embodiment two: the preparation of the drop pill that is used for preventing and treating liver fibrosis
[0042] The ginger extract obtained in Example 1 was used as the drug in the dropping pills. In order to better solve the stability of the main medicinal ingredient gingerol, part of the refined ginger oil was clathrated with β-CD. The formulation design of the sustained-release dropping pill contains both the extract and the clathrate, and the ratio of the two is adjusted to obtain different drug release effects.
[0043] Preliminary tests were carried out on the auxiliary materials and proportions of the dropping pills. Weigh a certain amount of excipients, heat and melt, cover and seal and keep warm at 60°C, drop into methyl silicone oil to condense, after shrinking into pellets, collect the pellets, absorb the coolant adhered to the surface, and put them in the dryer to dry. have to. The difficulty of making pills from each prescription is evaluated from the fol...
Embodiment 3
[0048] Example 3: Application test of ginger extract dripping pills in the treatment of liver fibrosis
[0049] The ginger extract dripping pill that obtains with embodiment two carries out various comparative tests, and test result sees the following tables, shows:
[0050] 1. In the whole animal acute liver injury experiment, refined ginger oil has obvious hepatoprotective effect, and it can inhibit the increase of animal serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) caused by carbon tetrachloride and acetaminophen (Table 1, Table 2); The elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels are significantly reduced (Table 3), and refined ginger oil can also reduce hepatocyte malonyltransferase caused by carbon tetrachloride damage. Aldehyde (MDA) content was elevated and superoxide dismutase (SOD) activity was elevated (Table 4). Pathological examination showed that refined ginger oil could significantly improve th...
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