Low-frequency stage microwave pulse irradiation system for improving the permeation of medicine in the blood brain barrier and the method thereof
A blood-brain barrier, low-frequency technology, applied in the medical field, can solve the problem of large side effects caused by microwave continuous wave heating, and achieve the effects of simple instrument manufacturing and implementation methods, avoiding side effects, and promoting targeted opening.
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Embodiment 1
[0014] Embodiment 1 Composition and mode of action of low-frequency microwave pulse irradiation system
[0015] The microwave pulse irradiator is made up of microwave pulse generator (accompanying drawing 1), controller 6 and irradiator (accompanying drawing 2) three main parts and auxiliary parts such as bed (referring to Fig. 1 and Fig. 2).
[0016] The microwave pulse generator is composed of a constant current charging power supply 1 , a modem 2 , a pulse transformer 3 , a microwave tube 4 and an auxiliary power supply 5 . The irradiator 7 is composed of a pulse signal input terminal 8, a radiation electrode 9, a shield 10, a rotation shaft 11 of the shield, a base 12 of the irradiator, a hospital bed 13, and the like.
[0017] In the above system, the microwave pulse generator generates microwave pulses. Under the action of the controller 6, the microwave generator generates microwave pulses with adjustable repetition frequency and amplitude. Pulse parameters: frequency i...
Embodiment 2
[0019] Embodiment 2 The method of using the low-frequency band microwave pulse irradiation system
[0020] The method of using the irradiation system will be described with reference to FIG. 2 .
[0021] 1) Turn on the power;
[0022] 2) According to the doctor's prescription, set the repetition frequency, pulse amplitude, and number of pulses on the controller; if the frequency is 10MHz to 1GHz, the pulse width is 5ns to 5000ns, and the pulse repetition frequency is single to tens of kilohertz.
[0023] 3) Open the shielding cover along the rotating shaft;
[0024] 4) The patient lies flat on the hospital bed, and the head falls on the concave part of the base of the irradiator;
[0025] 5) Close the shielding cover (before closing the shielding cover, the radiometer will not emit pulses);
[0026] 6) Press the start switch on the controller panel, the microwave pulse generator runs at the set repetition frequency and pulse amplitude, and the irradiator stops working when ...
Embodiment 3
[0028] Embodiment 3 Evan's blue (EB) tracing test
[0029] Use the system of Implementation 1 to carry out the following tests:
[0030] In the first experiment, lanthanum nitrate tracer method and electron microscope were used to observe the changes in the permeability of the blood-brain barrier of rats after a certain intensity of microwave pulse irradiation. Lanthanum is a commonly used tracer at the ultrastructural level. Its average particle size is 0.4×10-9m. When the cell membrane permeability is normal, it only exists in the extracellular space and cannot enter the cell. Therefore, it is often used to judge tissue cells. Whether there are tight junctions, barrier function and cell membrane permeability changes between cells. The test showed that, compared with the normal group, 2 hours after a certain intensity of microwave pulse irradiation, the space around the capillaries increased, the tight junctions opened, and more lanthanum particles exuded (Figure 3). It sho...
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