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Application of 20(S)-panaxcoside -Rg3 in preparation of medicine for treating or preventing high blood pressure

A technology of ginsenoside and hypertension, applied in the field of application of 20(S)-ginsenoside-Rg3 in the preparation of medicines for treating or preventing hypertension

Inactive Publication Date: 2009-08-12
山东同余堂人参科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] According to reports, Rg3 has anti-tumor, anti-angiogenesis, anti-inflammation and other effects, but about 20(S)-ginsenoside Rg 3 There is no report on the effect of preventing or treating hypertension; in view of this, the inventor has surprisingly found that 20 (S)-ginsenoside Rg 3 It has the medicinal purpose of preventing or treating hypertension

Method used

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  • Application of 20(S)-panaxcoside -Rg3 in preparation of medicine for treating or preventing high blood pressure
  • Application of 20(S)-panaxcoside -Rg3 in preparation of medicine for treating or preventing high blood pressure
  • Application of 20(S)-panaxcoside -Rg3 in preparation of medicine for treating or preventing high blood pressure

Examples

Experimental program
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Effect test

preparation example 1

[0012] Preparation Example 1: Preparation of 20(S)-ginsenoside Rg3

[0013] Take Panax notoginseng saponins (or ginsenosides) as raw material, add 50% acetic acid aqueous solution, heat in a water bath at 70°C for 6 hours, cool, add 5% sodium carbonate solution, extract the solution with n-butanol, evaporate the extract to dryness, and put Silica gel column, using chloroform-methanol as eluent, gradient elution to obtain 20(S)-ginsenoside Rg3, and repeated silica gel column chromatography to obtain 20(S)-ginsenoside Rg3.

preparation example 2

[0014] Preparation Example 2: Preparation of Injection

[0015] Weigh 0.50g 20(S)-ginsenoside Rg3, add 50g PEG-400 to dissolve the saponin; prepare 50g pH5.5 phosphate buffer, weigh 0.02g sodium bisulfite and add to the above phosphate buffer ; Add the buffer solution to the PEG solution of saponin, mix evenly, add 0.01% activated carbon for needles and incubate at 100°C for 30 minutes, G 3 Filtration with a vertically fused glass funnel and a 0.22um microporous membrane. The filtered medicinal solution is packaged into 50 injections of 2ml each.

preparation example 3

[0016] Preparation Example 3: Preparation of Freeze-dried Powder for Injection

[0017] Weigh 0.50g20(S)-ginsenoside Rg 3 , add 50g PEG-400 to dissolve the saponin. Prepare 50g of pH5.5 phosphate buffer, weigh 0.02g of sodium bisulfite and add it to the above phosphate buffer; add the buffer to the PEG solution of saponin, mix well, add 0.01% activated carbon for needles, 100°C Keep warm for 30 minutes, G 3 Filtration with a vertically fused glass funnel and a 0.22um microporous membrane; the filtered medicinal solution is divided into 2ml / vials, and freeze-dried by a freeze dryer to make a freeze-dried powder for injection.

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Abstract

The invention provides the application of 20(S)-ginsenoside-Rg3 in the preparation of medicines for treating or preventing hypertension, and the invention also provides a pharmaceutical composition containing 20(S)-ginsenoside-Rg3, the pharmaceutical composition Administration can be by oral, sublingual, transdermal, intramuscular, subcutaneous or intravenous routes.

Description

technical field [0001] The present invention relates to 20(S)-ginsenoside Rg 3 Application in the preparation of medicines for treating or preventing hypertension. Background technique [0002] With the acceleration of population aging process and changes in lifestyle, cardiovascular and cerebrovascular diseases have become a global health problem. The mortality rates of coronary heart disease and stroke rank first and third in the world respectively. Hypertension has always been considered is a major risk factor for stroke. The development of new and effective anti-hypertensive drugs is urgent. [0003] 20(S)—Ginsenoside Rg 3 It is a tetracyclic triterpenoid panaxadiol saponin monomer isolated from ginseng. [0004] [0005] 20(S)—Ginsenoside Rg 3 Structural formula (R: -glu-o-glu; R 1 : -OH; R 2 :-CH 3 ) [0006] According to reports, Rg3 has anti-tumor, anti-angiogenesis, anti-inflammation and other effects, but about 20(S)-ginsenoside Rg 3 There is no report...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K9/00A61P9/12
Inventor 田京伟傅风华蒋王林王超云
Owner 山东同余堂人参科技有限公司
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