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Water soluble carbon nano tube of grafting phosphorylcholine and preparing method

A technology of grafting phosphorylcholine and carbon nanotubes, which is applied in the field of nanometers, can solve the problems of difficult application and poor biocompatibility of azo dyes, and achieve the effects of stable water solubility, obvious water solubility, and easy realization

Inactive Publication Date: 2009-09-23
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent application 200510018617.7 mixes commercialized carbon nanotubes with excess azo dye after purification, and then uses conventional physical grinding or ultrasonic dispersion methods to fully dissolve or disperse carbon nanotubes, but the biocompatibility of azo dyes is poor , although endowing carbon nanotubes with water solubility, it is still difficult to be applied in the field of biomedicine

Method used

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  • Water soluble carbon nano tube of grafting phosphorylcholine and preparing method
  • Water soluble carbon nano tube of grafting phosphorylcholine and preparing method
  • Water soluble carbon nano tube of grafting phosphorylcholine and preparing method

Examples

Experimental program
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Effect test

Embodiment 1

[0030] The first step, acidification of carbon nanotubes: take 2 g of multi-walled carbon nanotubes and put them in a flask, add 75 mL of concentrated sulfuric acid and 25 mL of concentrated nitric acid, and use an ultrasonic cleaner (power 50W to 1000W is acceptable) for 24 hours after ultrasonic treatment at room temperature Centrifuge, pour off the upper layer of acid solution, add 50mL of distilled water, centrifugal separation after ultrasonic dispersion, pour off the supernatant liquid, repeat this process until the pH value of the clear liquid is neutral, centrifuge to obtain a solid, and vacuum dry to obtain acidified Carbon nanotube CNT-COOH 1.9g.

[0031] The second step, the acid halide of acidified carbon nanotubes: take the acidified carbon nanotubes CNT-COOH in the first step and put them in a flask, add 30mL of thionyl chloride dropwise, ultrasonically disperse for 3 hours, then raise the temperature to 70°C under stirring and reflux React for 24 hours. After t...

Embodiment 2

[0037] The same process as in Example 1, except that the multi-walled carbon nanotubes were replaced with single-walled carbon nanotubes, obtained water-soluble single-walled carbon nanotubes grafted with phosphorylcholine.

Embodiment 3

[0039] Same as Example 1, except that the acidification of carbon nanotubes in the first step does not require ultrasonic treatment, but adopts the method of heating and refluxing at 70° C. (50-120° C.) for 24 hours to obtain grafted phosphorylcholine Water-soluble carbon nanotubes.

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Abstract

The invention provides a water-soluble carbon nanotube grafted with phosphorylcholine and a preparation method thereof. The carbon nanotubes are subjected to acidification and acid halide treatment, and then the spacers characterized by aminoalcohol are grafted, and then the phosphorylcholine groups are grafted to obtain water-soluble carbon nanotubes. The mechanism of the preparation process is clear, reliable and easy to realize. The product has obvious water solubility and is stable. Phosphorylcholine is a part of a class of compounds inherent in organisms such as phospholipids, so water-soluble carbon nanotubes grafted with phosphorylcholine may have biocompatibility and have the possibility of being applied in the biomedical field.

Description

technical field [0001] The invention belongs to the field of nanotechnology, and in particular relates to a water-soluble carbon nanotube grafted with a biocompatible phosphorylcholine group and a preparation method thereof. Background technique [0002] In 1991, Iijima first discovered that carbon nanotubes are nanoscale tubular materials composed entirely of carbon atoms. Further studies have shown that carbon nanotubes are tubular objects composed of graphite-like hexagonal networks. Tubes are generally composed of single-layer or multi-layer tubes, called single-wall carbon tubes and multi-wall carbon tubes. 0.4-3nm and 1.4-100nm respectively, the length can reach several microns or even millimeters, and the interlayer spacing of multi-walled carbon tubes is 0.34nm. Carbon tubes have excellent mechanical properties, featuring low density, high modulus, and high strength, as well as excellent heat resistance and stability. In the past ten years, various disciplines have...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B31/02B82B3/00
Inventor 张弢顾民蒋正生
Owner NANJING UNIV
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