Vitamin U belladonna and aluminium dispersible tablet and its preparation process

Abstract

The invention relates to a vitamin U belladonna aluminum dispersible tablet and its preparation process, belonging to the field of medical technology, and specifically relates to the improvement of the preparation process of vitamin U belladonna aluminum; vitamin U II, aluminum hydroxide, and belladonna extract are used as raw materials, and starch is used as a filler , adding microcrystalline cellulose, sodium carboxymethyl starch, talcum powder, and magnesium stearate to make dispersible tablets. The process is: take vitamin U II and aluminum hydroxide, pulverize them separately, and sieve them; Sieve preparation; sieve belladonna extract and appropriate amount of starch; sieve and mix with internally added auxiliary materials and mix uniformly by equal incremental method; make the above mixture into soft material with 10% starch slurry, and granulate with sieve; hot air drying ; sieve and mix with additional auxiliary materials, tabletting; the vitamin U belladonna aluminum dispersible tablet produced by the present invention has a fast disintegration speed compared with the original capsule, shortened to three minutes from 30-60 minutes of the original capsule , the disintegration speed is increased by 10-20 times, and the time to reach the peak blood concentration of the drug is also relatively shortened, so that the new drug of the present invention has a faster onset of effect and a more definite curative effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to vitamin U belladonna aluminum dispersible tablets and a preparation process thereof. The international patent classification number is A61K 9 / 00. Background technique [0002] At present, the drug vitamin U belladonna aluminum, which has a relatively good effect on treating stomach pain, gastric acid, and gastric distension, is named Starsu, and is very popular among patients. However, this product is a capsule, and the capsule has the disadvantage of slow disintegration speed. The disintegration time limit of the capsule is generally 10-40 minutes. Due to the common phenomenon of serious aging in the capsule, after one and a half years of storage, the time limit for the disintegration of the capsule shell Generally more than 40 minutes, the time to reach the peak is longer, which affects the rapid effect of the drug and has a certain impact on the absorption of the ...

AI Technical Summary

Problems solved by technology

However, this product is a capsule, and the capsule has the disadvantage of slow disintegration speed. The disintegration time limit of the capsule is generally 10-40 minutes. Due to the common phenomenon of serious aging in the capsule, after one and a half years of storage, the time limit for the disintegration of the capsule shell Generally more than 40 minutes, the time to reach the peak is longer, which affects the rapid effect of the drug and has a certain impact on the absorption of the drug. It takes a long time for patients to relieve stomach pain, gastric acid, and bloating; quickly eliminate stomach pain, gastric acid, The key to the symptoms of gastric distension is that the disintegration and dissolution time of the drug in the stomach should be short. Therefore, a new drug in the form of vitamin U belladonna aluminum dispersible tablets was developed to shorten the time limit for disintegration of the drug and quickly alleviate the symptoms of stomach problems. pain, significant

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