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Fluorocarbon emulsion analog adjuvant for high-intensity focusing ultrasonic therapy and its uses

A focused ultrasound and fluorocarbon emulsion technology, used in ultrasound therapy, medicine and medical fields, can solve the problems of low target energy, burns, and decreased treatment efficiency, and achieve the effects of increasing energy deposition, enhancing absorption characteristics, and improving efficiency.

Active Publication Date: 2009-12-30
CHONGQING HAIFU (HIFU) TECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, when using HIFU technology to treat deep and large tumors, the attenuation of energy will inevitably lead to low energy in the target area, decreased treatment efficiency, and prolonged treatment time.
[0004] Of course, in order to improve the treatment efficiency, the transmission power of the ultrasonic transducer can be simply increased. However, in a high-intensity ultrasonic environment, the possibility of normal tissues on the ultrasonic propagation channel being burned will be greatly increased.
[0005] In addition, when HIFU technology is used clinically to treat liver tumors with ribs blocking the acoustic channel, in order to increase the energy deposition in the treatment target area, improve the treatment speed and treatment effect, it is often necessary to resect the ribs on the acoustic channel before treatment. This is contrary to the concept of HIFU non-invasive treatment, so it is difficult to be recognized by patients and doctors
[0006] The existence of these factors will inevitably affect and limit the promotion and popularization of HIFU as a clinically applicable technology to a certain extent.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]First 3% (W / V) emulsifier Pluronic F-68 (purchased from Sigma Company), 0.5% (W / V) egg yolk lecithin (purchased from Shanghai Chemical Reagent Company), 5% (V / V) whole Fluoropentane (purchased from Sigma Company) was mixed with 1000 ml of distilled water, and sheared and dispersed at 10,000 rpm for 5 minutes under ice-water bath conditions to form a coarse milk. Put the crude milk into a high-pressure homogenizer at 4°C, emulsify twice to obtain an emulsion, and filter through a 1 μm filter membrane to obtain an emulsion with particles smaller than 1 μm. Pack into 15ml bottles, and then irradiate with 20KGY cobalt 60 for 10 hours, the particle concentration is 10 9 / ml, refrigerated for later use.

Embodiment 2

[0030] First the emulsifier Pluronic F-68 (purchased from Sigma Company) of 6% (W / V), 1% (W / V) egg yolk lecithin (purchased from Shanghai Chemical Reagent Company), 10% (V / V) whole A total of 1000 ml of fluoropentane (purchased from Sigma) was mixed with physiological saline, and sheared and dispersed at 10,000 rpm for 5 minutes in an ice-water bath to form a coarse milk. Put the crude milk into a high-pressure homogenizer at 4°C, emulsify twice to obtain an emulsion, and filter through a 1 μm filter membrane to obtain an emulsion with particles smaller than 1 μm. Pack into 15ml bottles, and then irradiate with 20KGY cobalt 60 for 10 hours, the particle concentration is 10 9 / ml, refrigerated for later use.

Embodiment 3～6

[0032] According to the same method and steps as described in Example 1, the fluorocarbon emulsion auxiliary agent for HIFU treatment of the present invention was obtained according to the materials and proportions used in Table 1 below, and the corresponding parameters are shown in Table 1 below:

[0033] Table 1

[0034] Example 3

[0035] Hereinafter, taking the fluorocarbon emulsion auxiliary agent for HIFU treatment prepared in Example 1 as an example, combined with the joint use of the JC type HIFU tumor treatment system, the effect of the auxiliary agent of the present invention will be illustrated.

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PUM

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Abstract

The invention discloses a fluorocarbon emulsion auxiliary agent for increasing targeted area tissue energy deposition in HIFU treatment, which includes non-continuous phase constituted by filming material coating and continuous phase constituted by water-based medium, the non-continuous phase is dispersed in the continuous phase homogeneously, grain size of the non-continuous phase is 0.1-2um, the content of the film-forming material in the auxiliary agent is 0.1-100g / L, the core material is a liquid for generating liquid / gaseous phase change at 38-100 deg C, the content in the auxiliary agent is -200mg / L. The invention also discloses the use of the fluorocarbon emulsion auxiliary agent in HIFU treatment.

Description

technical field [0001] The present invention relates to the field of medicine and medical treatment, in particular, the present invention relates to the field of ultrasonic therapy, more specifically, the present invention relates to a fluorocarbon emulsion auxiliary agent for HIFU treatment that can increase the energy deposition of target area tissue during HIFU treatment and its application. Background technique [0002] High-intensity focused ultrasound (HIFU) technology has been clinically recognized as a new method for treating tumors and other diseases. It forms high-intensity and continuous ultrasonic energy on the lesion by focusing ultrasonic waves, thereby producing transient high-temperature effects (65-100°C), cavitation effects, mechanical effects, and sonochemical effects, and selectively causing coagulation necrosis of lesion tissues. The tumor loses the ability to proliferate, invade and metastasize. [0003] Studies have shown that during the propagation ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/22
CPCA61K9/0019A61K41/0033A61K49/226A61K9/0009A61K9/1075A61K9/107A61K31/685A61P35/00A61P35/04A61P43/00A61K9/127A61K49/22
Inventor 王智彪李发琪肖子文肖雁冰刘丽萍王芷龙
Owner CHONGQING HAIFU (HIFU) TECHNOLOGY CO LTD
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