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Technology of synthesizing nano bismuth stearate by liquid phase dispersing process

A liquid phase dispersion method, stearic acid technology, applied in the direction of nanotechnology, nanotechnology, nanostructure manufacturing, etc., to achieve the effect of large coverage, promotion of ulcer healing, and low production cost

Active Publication Date: 2007-07-18
HUNAN JINWANG BISMUTH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But do not see the synthetic method report of relevant nano bismuth stearate so far

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  • Technology of synthesizing nano bismuth stearate by liquid phase dispersing process

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Embodiment 1

[0031] A process for synthesizing nano-bismuth stearate by a liquid phase dispersion method. The process flow is as follows:

[0032] (1) Add stearic acid to the reaction kettle and heat at normal pressure to increase the temperature by 70~88℃ to melt;

[0033] (2) Take 1% of the dispersant-edible glycerol according to the added amount of stearic acid and mix it into the reaction kettle, mix and stir for 15 minutes;

[0034] (3) Under the condition of continuous stirring, slowly add metered bismuth subcarbonate, heat it to 100-102°C, keep the temperature constant, control the reaction time for 40-70 minutes, and synthesize bismuth stearate suspension emulsion;

[0035] Among them, the amount of bismuth subcarbonate added should be controlled at the theoretical demand G. The weight G of the unit weight of stearic acid and the added bismuth substearate is calculated as follows:

[0036] G=[H×M×(1.01~1.02)] / 56.1×100×2×X

[0037] In the formula: the acid value of H-stearic acid, mgKOH...

Embodiment 2

[0044] A process for synthesizing nano-bismuth stearate by a liquid phase dispersion method is characterized in that the process flow is carried out as follows:

[0045] (1) Add stearic acid to the reaction kettle and heat at normal pressure to increase the temperature by 75-85°C to melt;

[0046] (2) Take 0.5% isopropanol according to the added amount of stearic acid and mix it into the reactor, mix and stir for 10 minutes;

[0047] (3) Under the condition of constant stirring, slowly add metered bismuth subcarbonate, heat to 100-102°C, keep constant temperature, control the reaction time for 55-75 minutes, and synthesize bismuth stearate suspension emulsion;

[0048] Among them, the amount of bismuth subcarbonate added should be controlled at the theoretical demand G. The weight G of the unit weight of stearic acid and the added bismuth substearate is calculated as follows:

[0049] G=[H×M×(1.01~1.02)] / 56.1×100×2×X

[0050] In the formula: the acid value of H-stearic acid, mgKOH...

Embodiment 3

[0057] A process for synthesizing nano-bismuth stearate by a liquid phase dispersion method is characterized in that the process flow is carried out as follows:

[0058] (1) Add stearic acid to the reaction kettle and heat at normal pressure to increase the temperature to 85~90℃ to melt;

[0059] (2) Take 0.8% sorbitol based on the added amount of stearic acid and mix it into the reactor, mix and stir for 20 minutes;

[0060] (3) Under the condition of constant stirring, slowly add metered bismuth subcarbonate, heat to 100-102°C, keep constant temperature, control the reaction time for 60-80 minutes, and synthesize bismuth stearate suspension emulsion;

[0061] Among them, the amount of bismuth subcarbonate added should be controlled at the theoretical demand G. The weight G of the unit weight of stearic acid and the added bismuth substearate is calculated as follows:

[0062] G=[H×M×(1.01~1.02)] / 56.1×100×2×X

[0063] In the formula: the acid value of H-stearic acid, mgKOH / g;

[0...

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Abstract

This invention relates to a technology of using liquid-phase dispersion method to synthesize nanometer stearate Bismuth, belongs to stearic acid metal salts field. Its process: first will add the reactor of stearic acid, atmospheric heating to melt; second will add dispersant of the same amount as stearic acid to reactor, mixing them; the third step is under continuously mixing conditions, slowly add bismuth carbonate of 1.01 to 1.02 times of theory demand amount, and maintain a constant temperature, to synthesize stearic acid bismuth suspended emulsion; forth will centrifugal separate the stearic acid bismuth suspended emulsion, drying to gain micron stearate bismuth; at last send micro-stearate Bismuth to smash equipment, through airflow, finally obtain nanometer-stearate bismuth products. This invention has good dispersion, and high purity, big coverage, access to gastrointestinal lesions. It can diffuse directly to form protective layer, promoting mucosa and mucosal ulcer healing, is a brand new structure of the mucosal protective agent, can be a category of new drugs.

Description

Technical field [0001] The invention relates to a bismuth preparation production process, belonging to the field of metal stearate, and more specifically to a process for synthesizing nano bismuth stearate by a liquid phase dispersion method. Background technique [0002] It is often said that "everyone eats whole grains, who can be without disease", and the first thing that affects the stomach is the intake of food. With the development of society, people’s survival pressure is increasing. Due to work, life and other reasons, the proportion of gastrointestinal patients is increasing. According to incomplete statistics, the global gastrointestinal patients account for more than 10% of the total population. . As the saying goes, stomach diseases cause all kinds of diseases. Therefore, in the face of such a large group of patients with gastrointestinal diseases, the treatment of gastrointestinal diseases has caused more studies by experts and scholars. A considerable majority of pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/41C07C53/126B82B3/00
Inventor 谢大鹏雷日华吴祖祥戴艳平
Owner HUNAN JINWANG BISMUTH
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