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Slow release preparation of cefalexin

A slow-release preparation, the technology of cephalexin, which is applied in the field of sustained-release preparations of cephalexin, can solve the problems of affecting drug efficacy, inconvenience for patients, and affecting the steady-state blood drug concentration of the drug, so as to reduce the frequency of medication, effectiveness or adaptation sex enhancing effect

Inactive Publication Date: 2007-07-25
刘凤鸣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dosage for adults is oral, usually 250-500mg once a day, 4 times a day, which brings inconvenience to patients. At the same time, due to the influence of sleep time and other factors, it affects the steady-state blood drug concentration of the drug, thus affecting the efficacy of the drug.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The preparation of embodiment 1-cephalexin sustained-release tablet (1)

[0050] Method: Take 250 grams of cephalexin, 50 grams of hydroxypropyl cellulose, 15 grams of hypromellose, 10 grams of lactose, 10 grams of microcrystalline cellulose, 1 gram of carbomer, and 30 grams of polyethylene glycol 4000. Mix evenly, granulate by dry method, add magnesium stearate to mix, and compress into tablets to obtain a finished product with a drug content of 250 mg / tablet. Then the dissolution rate of the cephalexin sustained-release tablet (1) in 900 ml of water at 37° C. was measured. After release measurement, the results are shown in Table 1, which meets the requirements.

[0051] The dissolution rate of table 1 cephalexin sustained-release tablet (1)

[0052] Sampling time (hours)

Embodiment 2

[0053] The preparation of embodiment 2-cephalexin sustained-release tablet (2)

[0054] Method: Take 250 grams of cephalexin, 10 grams of hydroxypropyl cellulose, 20 grams of stearyl alcohol, 15 grams of hypromellose, 1 gram of carbomer, and 10 grams of lactose, pass through 80-mesh sieve, grind and mix well , adding a 95% ethanol solution of 10% polyvinylpyrrolidone as a binder and stirring to make a soft material, granulating through a 16-mesh sieve, drying the granules at room temperature for 2 hours, granulating through a 16-mesh sieve, and then adding stearic acid 4.5 grams of magnesium, 2 grams of micropowder silica gel, mixed evenly, and tableted to obtain a finished product, with a drug content of 250 mg / tablet. Then the dissolution rate of the cephalexin sustained-release tablet (2) in 900 ml of water at 37° C. was measured. After release measurement, the results are shown in Table 2, which meets the requirements.

[0055] The dissolution rate of ta...

Embodiment 3

[0057] The preparation of embodiment 3-cephalexin sustained release tablet (3)

[0058] Method: Take 250g of cephalexin, 35g of hypromellose, 5g of microcrystalline cellulose, and 1g of carbomer respectively, pass through a 80-mesh sieve, mix well, add a 95% ethanol solution of 10% polyvinylpyrrolidone as The binder is stirred to make a soft material, granulated through a 16-mesh sieve, dried at 60°C for 1 hour, granulated through a 16-mesh sieve, then added with 2.5 grams of magnesium stearate, mixed evenly, and pressed into tablets to obtain a finished product with a drug content It is 250mg / tablet. Then, the dissolution rate of the cephalexin sustained-release tablet (3) in 900 ml of water at 37° C. was measured. After release measurement, the results are shown in Table 3, meeting the requirements.

[0059] The dissolution rate of table 3 cephalexin sustained-release tablet (3)

[0060] Sampling time (hours)

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PUM

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Abstract

A slowly-released medicine of cefa-iskia in the form of dispersing solid is prepared from cefa-iskia and slow-releasing skeleton.

Description

[0001] [Technical field] The present invention relates to the slow-release preparation of cephalexin and preparation method thereof. [Background technique] [0002] The research and development of sustained-release preparations has a history of more than 40 years. It releases slowly and at a non-constant rate as required in a prescribed environment. Prolonged formulation. This kind of preparation can make the human body maintain this kind of blood drug concentration for a long time, instead of dropping rapidly like ordinary preparations, so as to avoid the "peak and valley" phenomenon that occurs when common preparations are frequently administered, and ensure the safety of the drug. Sexuality, effectiveness or adaptability have been improved, thereby reducing the number of medications, which greatly facilitates patients, especially patients who have been taking medication for a long time. Commonly used oral dosage forms include matrix tablets, microporous coated surface film...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K9/48A61K47/02A61K47/12A61K47/34A61K47/38A61K47/42A61K47/44A61K31/545A61P31/04A61K47/10A61K47/32
Inventor 刘凤鸣
Owner 刘凤鸣
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