A fabric enhanced composite vascular prosthesis

A fabric-enhanced, artificial blood vessel technology, applied in the field of artificial blood vessels, can solve the problems of poor anti-thrombosis, excessive intimal hyperplasia, poor anti-permeability, etc.

Active Publication Date: 2007-08-01
WUHAN YONGSEN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] In order to solve the problems of relatively poor anti-permeability of artificial blood vessels in the prior art, poor antithrombotic performance of small-calib...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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  • A fabric enhanced composite vascular prosthesis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: select polyester fabric as the fabric reinforcement layer, the blend of superfine silk powder and polyurethane as anticoagulant layer and elastic bonding layer, wherein the weight ratio of superfine silk powder and polyurethane in the anticoagulant layer is: 60:40, and the weight ratio of ultrafine protein powder and polyurethane in the elastic bonding layer is: 5:95.

[0027]First, the polyester staple fiber is processed into yarn on the spinning frame, and then processed into a tube fabric with a diameter of 4 mm on the warp knitting machine; the silk is processed into an ultrafine powder with a particle size of 2 microns; the polyurethane material is dissolved in DMF into a solution with a certain concentration, and the superfine silk powder is added to the polyurethane solution according to the weight ratio of silk ultrafine powder and polyurethane weight ratio of 60:40 and the weight ratio of silk ultrafine powder to polyurethane weight ratio of 5:95. ...

Embodiment 2

[0028] Embodiment 2: select silk fabric as the fabric reinforcement layer, the blend of superfine wool powder and polyurethane as anticoagulant layer and elastic bonding layer, wherein the weight ratio of superfine silk powder and polyurethane in the anticoagulant layer The formula is: 20:80, the weight ratio of ultrafine protein powder and polyurethane in the elastic bonding layer changes in a gradient.

[0029] Process the silk filaments on the loom into tubular fabrics with a diameter of 5 mm; process the wool into ultrafine powders with a particle size of 10 microns and 1 micron; dissolve the polyurethane material into a solution of a certain concentration with DMF, press Wool superfine powder and polyurethane weight ratio of 20:80 Add wool superfine powder with a particle size of 10 microns to the polyurethane solution, according to the wool superfine powder and polyurethane weight ratio of 5:95, 8:92, 10 : 90, 20: 80, the wool superfine powder with a particle size of 1 m...

Embodiment 3

[0030] Embodiment 3: Select spandex fabric as the fabric reinforcement layer, and polyurethane as the anticoagulant layer and elastic bonding layer.

[0031] Spandex filaments are processed on a loom into tubular fabrics with a diameter of 5 mm; the polyurethane material is dissolved into a solution of a certain concentration with DMF. First, a mold with a diameter of 5 mm is immersed in the polyurethane solution, and an anticoagulant layer is formed on the surface of the mold after drying; then a tube fabric with a diameter of 5 mm is placed on the surface of the same mold, and then repeatedly immersed in the polyurethane solution. After drying, it can be made into the initial artificial blood vessel shape, and then processed into the final artificial blood vessel after post-processing such as microporation and sulfonation.

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Abstract

The invention discloses a fabric reinforced composite artificial vessel to transplant into human body in the biological medical material manufacturing domain, which is composed of anticoagulant layer, reinforced fabric layer and elastic adhesive layer, wherein the reinforced fabric layer and elastic adhesive layer constitute the frame of artificial vessel; the reinforced fabric layer is buried in the elastic adhesive layer; the anticoagulant layer is set on the inner surface of artificial vessel frame of reinforced fabric layer and elastic adhesive layer, which forms blood flow channel; the anticoagulant layer and elastic adhesive layer are blending bulk of polyurethane or hyper-fine protein powder and polyurethane with grafted sulfuric group on the surface with micro-hole on the inner part.

Description

technical field [0001] The invention relates to a fabric-reinforced composite artificial blood vessel, in particular to an artificial blood vessel which can be implanted into a human body and has good antithrombotic properties and biocompatibility. Background technique [0002] The medical field has been able to treat most common human diseases. Implantable medical materials are widely used in surgical operations. A variety of implantable medical materials have achieved good medical effects in clinical practice, which can greatly solve the problem of patients. pain of. The development and manufacture of artificial blood vessels has a history of nearly 60 years. Since VoorheeS successfully developed the Vinyon "N" artificial blood vessel for the first time in 1952, and successfully used it clinically in the following year, people have successively researched and developed artificial blood vessels of various materials, shapes and porosity. [0003] The artificial blood vesse...

Claims

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Application Information

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IPC IPC(8): A61L29/12A61L33/12
Inventor 徐卫林欧阳晨曦姚穆裘法祖
Owner WUHAN YONGSEN BIOTECH
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