Amino acid diphenyl compound

A compound and amino acid technology, applied in the field of medicinal chemistry, can solve problems such as explosives, shortened existence time of compounds, toxicity, etc., and achieve good preventive or therapeutic effects
CN101007791AInactive Publication Date: 2007-08-01DONGHUA UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
DONGHUA UNIV
Publication Date
2007-08-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an amino acid phenyl benzene, which is comprised of phenyl benzene, amino acid and oxdiazole organically. It is the receptor blocking agent for angiotensin II and can be used for preparing medicine for treating or preventing high blood pressure, coronary disease, cerebrovascular disease, cephalagra, pulmonary arterial hypertension and so on.
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Description

technical field

[0001] The invention relates to the field of medicinal chemistry, in particular to a class of amino acid biphenyl compounds capable of treating hypertension and other cardiovascular and cerebrovascular diseases, migraine, pulmonary hypertension and other diseases. Background technique

[0002] Since the identification of hypertension in the 1940s, antihypertensive drugs have experienced the following development process. In the 1940s, malignant hypertension was first treated with the nerve blocker hexacarbonate quaternary ammonium, diuretics in the 1950s, anti-adrenaline blockers in the 1960s, further development of α-receptor blockers in the 1970s, and vascular tension in the 1980s In the 1990s, a new generation of antihypertensive drugs such as angiotensin-converting enzyme inhibitors, calcium channel blockers, and angiotensin receptor antagonists began to be used and developed vigorously.

[0003] In 1970, Marshall et al. synthesized the first receptor an...

Claims

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