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Process for preparing micronized medicine by using micro-reactor

A technology of micro-reactors and medicines, which is applied in the direction of making medicines into special physical or ingestible devices, powder delivery, etc., which can solve the problems of inconvenient emulsifier processing, high energy consumption, and increased raw material costs, and achieve continuous The effects of reaction stability, particle uniformity, and high bioavailability

Inactive Publication Date: 2007-08-08
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method involves ultrasonic conditions, not only high energy consumption, but also the introduction of emulsifiers brings inconvenience to the subsequent treatment process and increases the cost of raw materials

Method used

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  • Process for preparing micronized medicine by using micro-reactor
  • Process for preparing micronized medicine by using micro-reactor
  • Process for preparing micronized medicine by using micro-reactor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The reaction device that adopts is as shown in Figure 1, and bulk drug solution storage bottle 1 is connected with the advection pump 2 that is used to transport bulk drug solution by capillary line 6, and anti-solvent storage bottle 4 is passed through the advection pump 2 that is used to transport anti-solvent Capillary line 6 is connected, and microreactor 3 is connected with two advection pumps 2 respectively by capillary line 6, and in microreactor 3, the pipeline 7 that is used to transport bulk drug solution passes through capillary line 6 and is used for transporting bulk drug solution. The advection pump 2 is connected, the pipeline 7 for transporting the anti-solvent is connected with the advection pump 2 for transporting the anti-solvent through the capillary line 6, the angle between the pipeline 7 for transporting the bulk drug solution and the pipeline 7 for transporting the anti-solvent 60°, a microspace 8 is formed between the outlets of the two pipelines...

Embodiment 2

[0037] The microreactor that adopts is identical with embodiment 1.

[0038] Take by weighing azithromycin bulk drug 4.0g, be dissolved in the ethanol of 20 ℃ and be mixed with the azithromycin ethanol solution 50ml that concentration is 0.08g / ml (being about 20% of the saturated concentration of azithromycin in ethanol under 20 ℃), place in raw material In the medicine solution storage bottle, take 500ml deionized water in the anti-solvent storage bottle as the anti-solvent. Azithromycin ethanol solution and deionized water are introduced into the microreactor through the solution inlet and the antisolvent inlet by using a parallel flow pump, and the two fluids intersect at the intersection of the microchannel and are mixed rapidly and completely, and the resulting product slurry is discharged from the Mouth collection. The feed rates of azithromycin solution and water were 8ml / min and 80ml / min, respectively, and the recrystallization temperature was 20°C. The recrystallize...

Embodiment 3

[0040] The microreactor that adopts is identical with embodiment 1.

[0041] Take by weighing 1.0g of danazol crude drug, dissolve it in 20 DEG C of ethanol and prepare the danazol ethanol solution with a concentration of 0.02g / ml (about 92% of the saturation concentration of danazol in ethanol at 20 DEG C) 50ml, placed in the crude drug solution storage bottle, and 500ml deionized water was placed in the anti-solvent storage bottle as the anti-solvent. The danazol ethanol solution and the deionized water are introduced into the microreactor substantially simultaneously through the solution inlet and the anti-solvent inlet respectively by using an advection pump, and the two fluids intersect at the intersection of the microchannel and are mixed rapidly and completely, and the resulting product slurry is obtained from The outlet is collected. The feed rates of the danazol solution and water were 7ml / min and 70ml / min, respectively, and the recrystallization temperature was 20°C...

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Abstract

The invention relates to a method for using micro reactor to prepare micro powder drug, which comprises that dissolving the material drug into organic solvent to prepare the drug solution; then using respective advection pump 2 of material solution and reverse solvent to input them into the micro reactor 3 connected with the pump 2, while the flow speeds of drug solution and the reverse solvent is rated at 1:1-1:80; the micro reactor 3 contains a tube 7 for transmitting drug solution and a tube 7 for transmitting reverse solvent at 0-180 degree corner; the outlets of two tubes 7 have a micro space 8 between; the drug solution and the reverse solvent are mixed at the outlets of tubes 7 to realize the reverse-solvent recrystallization while the recrystallization temperature is -10-50Deg. C, to obtain the recrystallization pulp, to be filtered, washed and dried to obtain the micro powder drug. The inventive method can control the diameter, with narrow granularity distribution, simple process and low cost.

Description

technical field [0001] The invention belongs to the field of medicine preparation, in particular to a preparation method of micronized medicine. Background technique [0002] Drugs currently on the market include dosage forms such as dry powder inhalers, aerosols, tablets, capsules, and suspensions. [0003] For inhaled dosage forms such as dry powder inhalers and aerosols (eg, beclomethasone dipropionate), the drug is administered through the lungs. Due to the special physiological structure of the lungs, in order to achieve better lung deposition, there are certain requirements for the particles of inhaled drugs: (1) Particle size: drugs with a particle size of 0.5-5 μm are most likely to enter the bronchi and rapidly release the drug. (2) The particle size distribution of the drug is relatively narrow; (3) The drug should have better dispersibility and fluidity; (4) Since the amorphous drug has thermodynamic instability, the drug should be crystalline. Among the above-m...

Claims

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Application Information

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IPC IPC(8): A61J3/02A61K9/14
Inventor 陈建峰王哲赵宏王国联王洁欣
Owner BEIJING UNIV OF CHEM TECH
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