Process for preparing micronized medicine by using micro-reactor

A technology of micro-reactors and medicines, which is applied in the direction of making medicines into special physical or ingestible devices, powder delivery, etc., which can solve the problems of inconvenient emulsifier processing, high energy consumption, and increased raw material costs, and achieve continuous The effects of reaction stability, particle uniformity, and high bioavailability
CN101011316AInactive Publication Date: 2007-08-08BEIJING UNIV OF CHEM TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING UNIV OF CHEM TECH
Publication Date
2007-08-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a method for using micro reactor to prepare micro powder drug, which comprises that dissolving the material drug into organic solvent to prepare the drug solution; then using respective advection pump 2 of material solution and reverse solvent to input them into the micro reactor 3 connected with the pump 2, while the flow speeds of drug solution and the reverse solvent is rated at 1:1-1:80; the micro reactor 3 contains a tube 7 for transmitting drug solution and a tube 7 for transmitting reverse solvent at 0-180 degree corner; the outlets of two tubes 7 have a micro space 8 between; the drug solution and the reverse solvent are mixed at the outlets of tubes 7 to realize the reverse-solvent recrystallization while the recrystallization temperature is -10-50Deg. C, to obtain the recrystallization pulp, to be filtered, washed and dried to obtain the micro powder drug. The inventive method can control the diameter, with narrow granularity distribution, simple process and low cost.
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Description

technical field

[0001] The invention belongs to the field of medicine preparation, in particular to a preparation method of micronized medicine. Background technique

[0002] Drugs currently on the market include dosage forms such as dry powder inhalers, aerosols, tablets, capsules, and suspensions.

[0003] For inhaled dosage forms such as dry powder inhalers and aerosols (eg, beclomethasone dipropionate), the drug is administered through the lungs. Due to the special physiological structure of the lungs, in order to achieve better lung deposition, there are certain requirements for the particles of inhaled drugs: (1) Particle size: drugs with a particle size of 0.5-5 μm are most likely to enter the bronchi and rapidly release the drug. (2) The particle size distribution of the drug is relatively narrow; (3) The drug should have better dispersibility and fluidity; (4) Since the amorphous drug has thermodynamic instability, the drug should be crystalline. Among the above-m...

Claims

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