Traditional Chinese medicine solid preparation and its preparing process and use

A technology of solid preparations and traditional Chinese medicines, which is applied in the field of traditional Chinese medicine solid preparations of Houttuyfonate Sodium and its preparation, baicalin, containing Bupleurum saponins, and can solve the problems of low solubility and poor stability

Inactive Publication Date: 2007-08-08
PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Based on the above reasons, we have innovatively optimized the composition based on the effective parts of the total saponins of Bupleurum saponins, the active ingredients of baicalin and houttuyniatin sodium through the screening and systematic evaluation of the composition and proportion of the drug. Distributed into five prescriptions, they have synergistic and complementary effects on each other, and play a comprehensive regulatory therapeutic effect through multi-components or components, multi-targets, and multi-systems. It has a good therapeutic effect, especially for colds with respiratory tract, upper respiratory tract bacterial infection, and viral infection; the active ingredients or the effective parts of the components are quantified by high performance liquid chromatography, and the active ingredients or active ingredients in the prescription are comprehensively and objectively quantified. The content of the effective part of the component, the quality control system is precise, and the quality of the product is objectively and comprehensively reflected; based on the shortcomings of the total saponins of Bupleurum saponins and houttuyonin sodium and the poor stability of baicalin, through the optimization of the f

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  • Traditional Chinese medicine solid preparation and its preparing process and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0181] The raw materials are: 25 grams of total saponins of Bupleurum, 150 grams of baicalin, and 25 grams of houttuyonin sodium;

[0182]1. Process method

[0183] Extraction process:

[0184] (1) Take Radix Bupleurum, extract with 20% ethanol, concentrate the extract under reduced pressure, put it on an AB-8 macroporous adsorption resin column, wash with water to remove impurities, then elute with 4 times the column volume of 30% ethanol, discard and elute Liquid, then eluted with 70% ethanol, collected 4 times the column volume eluted part, concentrated, dried to obtain the total saikosaponins, the total saikosaponins are 10.1% as saikosaponin A;

[0185] Or: total saikosaponin is a standard extract sold in the market, and the total saikosaponin is 10.2% in terms of saikosaponin A;

[0186] Or: total saikosaponins obtained by extracting and purifying Bupleurum bupleuri by those skilled in the art using the prior art, and the total saikosaponins are 10.4% in terms of saiko...

Embodiment 2

[0201] The raw materials are: 50 grams of Bupleurum saponins, 200 grams of baicalin, and 50 grams of houttuyonin sodium;

[0202] 1. Process method

[0203] Extraction process:

[0204] (1) Get Radix Bupleuri, extract with 90% ethanol, concentrate the extract under reduced pressure, put it on a D101 macroporous adsorption resin column, wash away impurities with water, then elute with 8 times column volume of 50% ethanol, discard the eluent, Then elute with 70% ethanol, collect the eluted part with 6 times column volume, concentrate and dry to obtain the total saikosaponins, the total saikosaponin is 49.7% of saikosaponin A;

[0205] Or: total saikosaponins is a standard extract sold in the market, and the total saikosaponins meeting the standard is 49.1% in terms of saikosaponin A;

[0206] Or: the total saponins obtained by extracting and purifying Bupleurum bupleuri by those skilled in the art, the total saikosaponins are 49.7% in terms of saikosaponin A;

[0207] (2) Bai...

Embodiment 3

[0221] The raw materials are: 37.5 grams of Bupleurum saponins, 175 grams of baicalin, and 34 grams of houttuyonin sodium;

[0222] 1. Process method

[0223] Extraction process:

[0224] (1) Get Radix Bupleuri, extract with 55% ethanol, concentrate the extract under reduced pressure, put it on a D101 macroporous adsorption resin column, wash away impurities with water, then elute with 40% ethanol for 6 times the column volume, discard the eluent, Then elute with 70% ethanol, collect the eluted part with 5 times column volume, concentrate, and dry to obtain the total saikosaponins, the total saikosaponins are calculated as 25% by saikosaponin A;

[0225] Or: total saikosaponins is a standard extract sold in the market, and the total saikosaponins are 25.3% in terms of saikosaponin A;

[0226]Or: the total saponins obtained by extracting and purifying Bupleurum bupleuri by those skilled in the art using the prior art, and the total saikosaponins are 25.1% in terms of saikosap...

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Abstract

The invention relates to a method for preparing the traditional solid medicine, which uses the saikoside, baicalin and houttuynine sodium bisulfite sodium at different mass percentages, to build technical checking method and solubility testing method, via antiviral tests to select the best combination, and uses the solubility test to find the preparation.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to a traditional Chinese medicine solid preparation containing total saponins of Bupleurum baicalin, baicalin and houttuyonin sodium, a preparation method and application thereof. Background technique [0002] Chaihuang Granules and Chaihuang Tablets, issued by the Ministry of Traditional Chinese Medicine, are used to treat fever, general discomfort, headache, dizziness, and sore throat caused by colds. The compatible application of Bupleurum and Scutellaria comes from Xiaochaihu Decoction in "Treatise on Febrile Diseases". Fire detoxification, Bupleurum expells half-exterior and half-inside evils, Scutellaria baicalensis half-exterior and half-inner evils, Bupleurum opens Qingyang, and Scutellaria baicalen reduces turbid fire. Bupleurum preparations are prepared into preparations through the compatibility of Bupleurum and Scutellaria baicalensis. Trad...

Claims

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Application Information

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IPC IPC(8): A61K36/233A61K31/7048A61K9/16A61K9/20A61K9/48A61K47/34A61K47/38A61P11/04A61P11/14A61P11/00A61P29/00G01N30/02A61K31/185A61K47/10A61K47/20
Inventor 顾群李志刚魏俊玲郭小鹏渠守峰米长江姜威金治刚翟海燕林治荣
Owner PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING
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