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Supercritical safflower extracting process

A supercritical and safflower technology, applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., to achieve the effects of easy production of high-concentration pharmaceutical preparations, high yield, and high product concentration

Active Publication Date: 2007-08-22
山西华卫药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above method only extracts the components in the material once, and the process of using supercritical fluid fractional extraction to realize the integration of extraction and separation of products with different properties has not been reported yet.

Method used

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  • Supercritical safflower extracting process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Take 100 grams of safflower, crush it to 0.15mm-1mm, dry it at a low temperature below 60°C, put it in the extraction tank 7 and seal it. Open the gas tank 1, the carbon dioxide reaches the extraction tank 7 through the condensation tank 2 and the high-pressure pump 3, and conducts the first extraction at 8MPa and 35°C. The extract enters the primary separation tank 9, and performs primary separation at 8MPa and 12°C to obtain safflower wax. Carbon dioxide continues to enter the secondary separation tank 10, 4MPa, 30 ℃ secondary separation of safflower volatile oil. After 6 hours of dynamic operation, 0.6 grams of safflower volatile oil and 0.1 g of vegetable wax were obtained from the separation tank. The pressure was increased to 32mpa, and the safflower raffinate was extracted for the second time at a temperature of 35°C. The extract enters the separation tank 9 for separation, the pressure of the separation tank is 2MPa, and the temperature is 20°C. Af...

Embodiment 2

[0021] Example 2: Take 100 grams of safflower, crush it to 0.15mm-1mm, dry it at a low temperature below 60°C, put it in the extraction tank 7 and seal it. Open the gas tank 1, the carbon dioxide reaches the extraction tank 7 through the condensation tank 2 and the high-pressure pump 3, and conducts the first extraction at 10MPa and 50°C. The extract enters the primary separation tank 9, and performs primary separation at 9MPa and 10°C to obtain safflower wax. Carbon dioxide continues to enter the secondary separation tank 10, 6MPa, 35 ℃ secondary separation of safflower volatile oil. After 6 hours of dynamic operation, 0.7 g of safflower volatile oil and 0.12 g of vegetable wax were obtained from the separation tank. The pressure was increased to 28mpa, and the safflower raffinate was extracted for the second time at a temperature of 45°C. The extract enters the separation tank for separation, the pressure of the separation tank is 4MPa, and the temperature is 30°C. After ...

Embodiment 3

[0022] Example 3: Take 100 grams of safflower, crush it to 0.15mm-1mm, dry it at a low temperature below 60°C, put it in the extraction tank 7 and seal it. Open the gas tank 1, the carbon dioxide reaches the extraction tank 7 through the condensation tank 2 and the high-pressure pump 3, and conducts the first extraction at 12MPa and 60°C. The extract enters the primary separation tank 9, and performs primary separation at 9MPa and 12°C to obtain safflower wax. Carbon dioxide continues to enter the secondary separation tank 10, 4MPa, 30 ℃ secondary separation of safflower volatile oil. After 2 hours of dynamic operation, 0.9 g of safflower volatile oil and 0.13 g of vegetable wax were obtained from the separation tank. The pressure was increased to 25mpa, and the safflower raffinate was extracted for the second time at a temperature of 60°C. The extract enters the separation tank for separation, the pressure of the separation tank is 6MPa, and the temperature is 40°C. After ...

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Abstract

The supercritical safflower extracting process includes the following steps: the first extraction of the safflower material with supercritical CO2 as extractant, two-stage of decompression separation to obtain vegetable wax and volatile safflower oil, the second extraction of the safflower residue to obtain macromolecular non-polar matter, the third extraction of the safflower residue in the presence of entrainer and CO2 and decompression separation to obtain polar matter and entrainer. The present invention has high volatile safflower oil yield, realizes the extraction and separation of volatile oil and wax in one step and utilizes the non-polar matter in safflower effectively. The present invention has the advantages of high product concentration and capacity of producing high concentration medicine preparation easily.

Description

technical field [0001] The invention relates to the technical field of medical processing and application, and belongs to the field of using supercritical CO 2 A method for extracting volatile oil, macromolecular non-polar substances and polar extracts contained in safflower. Background technique [0002] Compositae safflower has a cultivation area of ​​30,000 to 40,000 hectares in my country, mainly concentrated in Xinjiang, Sichuan, Yunnan and Henan provinces. The flowers of safflower are used as medicine, which contain medicinal ingredients such as safflower yellow pigment, safflower glycosides, safflower polysaccharides and flavonoids. Clinical studies have shown that safflower extract has the effects of enhancing immunity, relaxing blood vessels, lowering blood fat, lowering blood pressure, stimulating the uterus, anti-inflammatory and anti-aging, etc. In addition, safflower volatile oil also has antibacterial effects. Therefore, safflower is widely used in the treatm...

Claims

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Application Information

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IPC IPC(8): A61K36/286A61P37/04A61P31/04A61P9/00A61P15/00A61P3/00A61K133/00
Inventor 毕继诚韩小金张荣王江泉
Owner 山西华卫药业有限公司
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