1-(3-indolyl)-6,7-methylene dioxy-1,2,3,4-tetrahydro isoquinoline derivative and its prepn and use

Abstract

The present invention belongs to the field of medicine synthesis technology, and is especially 1- (3-indolyl)- 6, 7-methylene dioxy-1, 2, 3, 4-tetrahydro isoquinoine compounds and analogs in the general expression as shown and with substituted hydroxyl radical or acyl radical in the 2nd position, and their preparation process and medical application. Initial pharmacodynamic research of extracorporeal rice blast mold resisting experiment and extracorporeal antitumor experiment shows that these compounds has excellent activity, so that they may be developed into antifungal medicine and antitumor medicine.

Description

technical field

[0001] The invention belongs to the field of medicine synthesis and relates to 1-(3-indolyl)-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline derivatives. It specifically relates to a 1-(3-indolyl)-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline derivative substituted with various hydrocarbon groups or acyl groups at the 2-position, Its preparation method and application in medicine. Background technique

[0002] With the popularization and abuse of antibiotics in the world, drug resistance tends to appear in both Gram-positive bacteria and negative bacteria, and the drug resistance problem of Gram-positive bacteria is even more serious. Some non-pathogenic bacteria have become conditional pathogens, such as Proteus, Pseudomonas aeruginosa, etc.; and infections such as viruses and deep fungi still lack good prevention and treatment drugs. And with the wide application of antineoplastic drugs, immunosuppressants, etc., the mass development of organ transp...

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