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Metal complex with liriodenine as ligand and its synthesis process and use

A technology of metal complexes and tulipwood bases, which is applied in the field of synthesis of metal complexes and can solve problems such as unavailable research results and technical reports

Inactive Publication Date: 2007-08-22
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, there are no public research results and technical reports on the pharmacologically active metal complexes synthesized by using the natural pharmacologically active ingredient tulipine as a ligand, as well as the synthesis methods and pharmacological activity studies of such complexes.

Method used

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  • Metal complex with liriodenine as ligand and its synthesis process and use
  • Metal complex with liriodenine as ligand and its synthesis process and use
  • Metal complex with liriodenine as ligand and its synthesis process and use

Examples

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Embodiment 1

[0023] Embodiment 1: Synthesis of cisplatin Pt by solution method II -LA complex

[0024] Cisplatinoid metal complexes [Pt II .(C 17 h 9 NO 3 ).Cl 2 ], has antitumor activity, and under the condition of definite structure, will be more helpful to the structure-activity relationship of research cisplatin drugs, the present invention synthesizes this kind of cisplatin complexes with the following synthetic routes, and synthetic steps are as follows:

[0025] 1 mmol K 2 PtCl 4 Dissolve 10ml of water, 1mmol of LA dissolved in 50ml, 70 ℃ ethanol, after the two solutions are mixed, stir and react at 70 ℃ for 10 hours, the reaction is under dark conditions, inert atmosphere (N 2); after the reaction was completed, it was lowered to 25°C to obtain a solution that produced a purple-red precipitate; the solution was filtered, the precipitate was washed with water and ethanol to remove impurities and unreacted substances, and vacuum-dried at 40°C for 12 hours to obtain a purple-re...

Embodiment 2

[0026] Embodiment 2: Synthesize Ru with solution method II -LA complex

[0027] Ru II Metal complexes with potential antitumor activity, Ru II considered to be Pt II An ideal substitute for metalloid complex antitumor drugs, and Ru II Its own toxic and side effects are better than those of Pt II Low, it has good application prospect as antitumor drug, the present invention has obtained this kind of metal complex with the following synthetic steps:

[0028] 0.5 g RuCl 3 .3H 2 O was refluxed in 3mL of DMSO, that is, the temperature was 190°C for 10 minutes to obtain a dark red solution; After standing for 24 hours, yellow crystals precipitate out, which is the intermediate product RuCl 2 (DMSO) 4 .

[0029] 1mmol intermediate product RuCl 2 (DMSO) 4 Dissolved in 25ml of chloroform; 1mmol of LA was dissolved in 25mL of chloroform, and the two solutions were mixed and reacted at 60°C for 6 hours, and a dark green solution was obtained after the reaction; the solution e...

Embodiment 3

[0030] Embodiment 3: synthesize Fe with solvothermal method II -LA complex

[0031] In a thick-walled glass tube open at one end, add 0.1mmol FeCl 2 .4H 2 O and 0.1mmol LA, then add a mixed solvent made of 1mL ethanol and 0.5mL water, under the condition of vacuum, seal the other open end, and then react at 110°C for 24 hours, remove after reaction solvent, take the resulting red solid and wash it with water and ethanol to remove unreacted substances and impurities, and dry it in vacuum at 40°C for 12 hours to obtain the red solid product FeCl 2 (C 17 h 9 NO 3 ) 2 .

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Abstract

The present invention relates to metal complex with lirodenine as ligand and its preparation process. The preparation process of the metal complex includes: dissolving metal salt and lirodenine in the molar ratio of 1 to 1-3 in polar solvent, reaction at 20-100 deg.c, filtering to obtain the precipitate, purifying and drying to obtain the metal complex. Or, the preparation process includes: dissolving metal salt and lirodenine in the molar ratio of 1 to 1-3 in polar solvent, reaction at 60-150 deg.c in vacuum condition, eliminating solvent after reaction, purifying and drying to obtain the metal complex. The metal complex has antitumor activity higher than that of lirodenine and high medicinal value, and may be used in preparing various kinds of antitumor medicine.

Description

(1) Technical field: [0001] The invention relates to a metal coordination compound, especially a metal complex with tulipine as a ligand, and also relates to a synthesis method and application of the metal complex. (two) background technology: [0002] Aporphim isoquinoline alkaloids are a series of alkaloids with strong pharmacological activity. For example, aporphim is an analgesic drug; oxysea papaverine and tulipine are alkaloids with significant antitumor activity. , the planarity of such molecules and the presence of hetero-N atoms, methylenedioxy and carbonyloxy groups have a significant relationship with their antitumor activity. Liriodenine is a kind of aporphenanthrene isoquinoline alkaloid that exists in Magnoliaceae, Rutaceae and other traditional Chinese medicine plants. From the current research on Liriodenine alkaloids, it mainly includes two Two aspects: On the one hand, it is quantitatively extracted and analyzed from plants of different families and genera...

Claims

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Application Information

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IPC IPC(8): C07F15/00C07F1/00C07F7/28C07F11/00C07F13/00C07F3/00C07D491/056A61K31/555A61P35/00
Inventor 陈振锋梁宏刘延成王恒山刘华钢杨斌
Owner GUANGXI NORMAL UNIV
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