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Function of Renyuan hepatic stellate cells for treating liver diseases by activating the corresponding protein

A technology of hepatic stellate cells and related proteins, which is applied to the medical application of human-derived hepatic stellate cell activation-related proteins and the treatment of liver diseases, and can solve the problems of hSTAP therapeutic function that has not been reported in the literature.

Inactive Publication Date: 2007-09-19
CHINA PHARM UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the therapeutic function of hSTAP has not been reported in the literature

Method used

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  • Function of Renyuan hepatic stellate cells for treating liver diseases by activating the corresponding protein
  • Function of Renyuan hepatic stellate cells for treating liver diseases by activating the corresponding protein
  • Function of Renyuan hepatic stellate cells for treating liver diseases by activating the corresponding protein

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Embodiment 1

[0045] MDA is one of the important end products of lipid peroxidation, which reflects the severity of the body's cells being attacked by free radicals, can promote the expression of type I collagen mRNA, and is closely related to HSC proliferation and collagen synthesis; SOD is the body's defense against oxidative damage. One of the most important antioxidant enzymes in the system, reflecting the body's ability to scavenge oxygen free radicals. Hydroxyproline (Hyp) is a specific amino acid component that constitutes collagen fibers. Collagen fibers are mainly composed of collagen, and the content of hydroxyproline in collagen is relatively stable, about 2.5%, and the content in non-collagen is very high. Low or even lacking, so hydroxyproline is often considered as a unique component of collagen. The content of Hyp in liver tissue cells can more accurately reflect the content of collagen fibers in liver tissue. Therefore, the determination of hydroxyproline content in liver tis...

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Abstract

The invention relates to a biological medicine domain, particularly a pharmaceutical application of a protein associated with activation of human hepatic stellate cell, namely an application of preparation of medicine for liver diseases. The invention also discloses a recombination preparation method.

Description

technical field [0001] The present invention relates to the field of biomedicine, in particular to the medical application of human-derived hepatic stellate cell activation-related protein, that is, its application for treating liver diseases. Background technique [0002] Hepatic stellate cell activation-associated protein (Stellate cell activation-associated protein STAP) is a protein closely related to the activation of hepatic stellate cell (HSC) found in rat liver proteomics research. It is significantly up-regulated during HSC activation (see Biol Chem. 2001, 276(27) 25318-25323). Through homologous comparison, human hepatic stellate cell activation-associated protein hSTAP was found in the human liver genome, and its nucleotide sequence can be found in AB057769 in GENEBANK. Immunohistochemical studies have shown that hSTAP mRNA is expressed to varying degrees in human brain, heart, liver, kidney and other tissue cells (see Biochim Biophys Acta. 2002, 1577: 471-475). ...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P1/16C12P19/34C12N15/63C12N15/70
Inventor 吴梧桐魏威
Owner CHINA PHARM UNIV
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