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Composite material for repairing bone defect

A composite material and bone defect technology, applied in medical science, prosthesis, etc., to achieve the effect of simple and feasible preparation process, good clinical application prospects, and wide sources

Inactive Publication Date: 2007-09-19
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in a related search, inorganic nano-hydroxyapatite and organic carboxymethyl chitosan were prepared into a composite material with a three-dimensional hole network structure similar to the mechanical properties, geometry and surface properties of natural cancellous bone, There have been no reports of it being used to repair bone defects

Method used

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  • Composite material for repairing bone defect
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  • Composite material for repairing bone defect

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Experimental program
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Effect test

Embodiment 1

[0033] Material preparation:

[0034] The preparation of nano-hydroxyapatite (nano HA powder) was prepared by conventional chemical precipitation; N, O-carboxymethyl chitosan was purchased from Qingdao Haihui Biological Engineering Co., Ltd., with a carboxymethyl substitution degree of 90.5%, The degree of deacetylation is 88.6%; p-dichlorobenzene, absolute ethanol, and citric acid are all analytically pure.

[0035] Preparation of composite material for repairing bone defect according to the present invention:

[0036](1) Nano-hydroxyapatite and carboxymethyl chitosan are proportioned respectively in the ratio of 6: 4 by mass ratio, and are fully mixed with mechanical ball milling;

[0037] (2) Then weigh the nano-hydroxyapatite / carboxymethyl chitosan composite powder and the pore-forming agent p-dichlorobenzene in a mass ratio of 1:1, grind and mix, and then ultrasonically vibrate for 2 hours to make it Mix well;

[0038] (3) adding mass percent in the mixture described i...

Embodiment 2

[0043] Preparation of nano-hydroxyapatite / carboxymethyl chitosan composite material for repairing bone defect according to the present invention:

[0044] (1) Nano-hydroxyapatite and carboxymethyl chitosan are proportioned respectively in a ratio of 7: 3 by mass ratio, and are fully mixed with mechanical ball milling;

[0045] (2) Then, the nano-hydroxyapatite / carboxymethyl chitosan composite powder and the pore-forming agent p-dichlorobenzene are weighed in a ratio of 1: 1.2 by mass, ground and mixed, and then ultrasonically oscillated for 2.5 hours to make It is thoroughly mixed;

[0046] (3) adding mass percent in the mixture described in step (2) is 16.7% citric acid solution and reconcile evenly, the citric acid solution consumption is as the criterion with the plasticity of mixture;

[0047] (4) Put the forming mixture into the artificial bone support standard mold, press forming, and keep the pressure for 80s;

[0048] (5) Demoulding, the formed composite material was...

Embodiment 3

[0051] Preparation of nano-hydroxyapatite / carboxymethyl chitosan composite material for repairing bone defect according to the present invention:

[0052] (1) Nano-hydroxyapatite and carboxymethyl chitosan are proportioned respectively in the ratio of 6.5: 3.5 by mass ratio, and are fully mixed with mechanical ball milling;

[0053] (2) Then weigh the nano-hydroxyapatite / carboxymethyl chitosan composite powder and the pore-forming agent p-dichlorobenzene in a mass ratio of 1:1.1, grind and mix, and then ultrasonically vibrate for 3 hours to make it Mix well;

[0054] (3) adding mass percent in the mixture described in step (2) is 16.7% citric acid solution and reconcile evenly, the citric acid solution consumption is as the criterion with the plasticity of mixture;

[0055] (4) Put the forming mixture into the artificial bone support standard mold, press forming, and hold the pressure for 100s;

[0056] (5) Demoulding, the formed composite material was placed in air for 5 ho...

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Abstract

The invention discloses composite material for repair of bone defect and preparation method. The invention synthesizes nanosized hydroxyapatite powders(HAP)by chemical precipitation, using anhydrous alcohol as leaching reagant and 16.7%(by mass fraction)of citric acid aqueous solution as binder. HA / CMCS porous material is prepared by particulate leaching and the IR, XRD, SEM, porosity, and compressive strength thereof are tested. The results show that two chemical compositions of HA / CMCS composite material have not remarkably changed before and after being compounded, but the two phases interacted with each other. The porosity of porous material is high, and the range of pore size distribution is wide, in shape of mainly rotundity, wherein the size distribution is about from several microns to 600 microns, with good interconnectivity, very beneficial to tissue growth and extending. When the CMCS content is 40% in composite material, the mass ratio of composite material and pore former is 1:1, the porosity of porous material is near 75% and the compressive strength is above 21MPa, meeting the requirements of scaffold materials for bone tissue engineering.

Description

technical field [0001] The invention belongs to the technical field of constructing artificial bone scaffolds by tissue engineering methods in biomedical engineering, and in particular relates to a composite material for repairing bone defects and a preparation method thereof. Background technique [0002] At present, the clinically used bone repair materials have their own advantages and disadvantages, and they cannot meet the ideal material requirements for repairing bone defects, such as the lack of a uniformly connected pore structure, the inconsistency between the degradation rate and the growth replacement rate of bone tissue, and the mismatch in mechanical strength and performance. In order to improve the mechanical properties of materials and the speed of new bone formation, growth factors or organic polymers are often introduced to improve their properties. Therefore, the construction of composite bone substitute materials similar to natural bone based on hydroxyapa...

Claims

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Application Information

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IPC IPC(8): A61L27/42
Inventor 赵冬梅王海斌刘军莉赵萍刘爱红赫淑倩孙康宁霍延青司海鹏
Owner SHANDONG UNIV
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