Medicine composition containing soya bean aglycone and its preparing method

A technology of daidzein and composition, which is applied in the field of daidzein pharmaceutical composition, and can solve problems such as the influence of daidzein derivatives on biological activity

Inactive Publication Date: 2007-10-03
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to improve the solubility of daidzein, improve its water solubility and bioavailability, Shi Chaozhou et al. improved the solubility of daidzein by structural modification of daidzein, that is, with methoxyl, hydroxyl, amino, acetamido, ester, Groups such as ether groups substitute the 4 or 7 positions of isoflavones, but the biological activities of the obtained daidzein derivatives are affected to varying degrees (Journal of Tongji Medical University 1990, 19(3): 188-203 )

Method used

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  • Medicine composition containing soya bean aglycone and its preparing method
  • Medicine composition containing soya bean aglycone and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Accurately weighed 15g of β-cyclodextrin and dissolved it in 30ml of water to obtain an aqueous solution of β-cyclodextrin. In addition, 250 mg of daidzein was accurately weighed and dissolved in 5 ml of ethanol, and then slowly injected into the aqueous solution of cyclodextrin, stirred for 6 hours to obtain a clear and transparent solution, after spray drying, it was packed into capsules by conventional methods, each capsule was 25 mg, and the drug combination of daidzein was obtained. capsules.

Embodiment 2

[0031] Accurately weigh 40g of hydroxypropyl-β-cyclodextrin, add 80ml of water to dissolve it, place it on a magnetic heating stirrer, and keep the temperature in a water bath at 60°C. In addition, accurately weigh 500 mg of daidzein, dissolve it in 5 ml of dimethyl sulfoxide, and slowly add it to the aqueous solution of hydroxypropyl-β-cyclodextrin. After 1 hour, remove the constant temperature water bath, and continue to stir at room temperature for 5 hours to obtain a clear and transparent solution. , add water to the liquid composition to 200ml, mix evenly, subpackage (25mg / branch), and sterilize to obtain the oral liquid of daidzein pharmaceutical composition.

Embodiment 3

[0033] Accurately weigh 200g of α-cyclodextrin and dissolve in 400ml of water. In addition, 2.5g of daidzein was accurately weighed and dissolved in 50ml of ethanol, slowly injected into the aqueous solution of α-cyclodextrin, stirred for 12 hours, and spray-dried to obtain a powdery to solid composition.

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PUM

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Abstract

A medical daidzein composition suitable to prepare solution-type medicine (such as injection) with high water solubility and no toxic by-effect is prepared from daidzein, cyclodextrin and water-soluble auxiliaries. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a daidzein pharmaceutical composition, more specifically to a pharmaceutical composition which takes daidzein as an active ingredient and contains cyclodextrin and a water-soluble auxiliary agent. The invention also relates to a process for the preparation of the composition. Background technique [0002] The main active ingredient of Pueraria lobata daidzein is one of the main components of isoflavones, which can be prepared by chemical synthesis or traditional Chinese medicine extraction and separation technology. Daidzein can expand coronary, femoral, and cerebral arteries, increase cerebral blood flow, significantly improve hypertension such as headache, dizziness, and neck pain, lower blood pressure, significantly relieve angina, improve heart function, reduce myocardial oxygen consumption, and resist heart rhythm. Abnormal, improve heart rate, anti-oxidation, enhance body immunity, strengthen blood circulation in extremi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P9/10
Inventor 李亚平陈伶俐顾王文
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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