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Traditional Chinese medicine for treating lung heat cough and high fever

A technology for lung-heat cough and composition, applied in the field of traditional Chinese medicine composition

Active Publication Date: 2007-10-03
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antibiotics can be used for co-infections such as bacterial infections, but there is currently no effective treatment for co-infections with viruses

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0034] Experimental example Antitussive effect test

[0035] Mice are divided into 5 groups at random, every group of 10, half male and half male, respectively blank control group, positive group and the high, middle and low dose groups of this pharmaceutical composition preparation (tablet) (dose is respectively 2.51g crude drug amount / kg, 7.54g crude drug amount / kg, 22.62g crude drug amount / kg). The mice in each group were given 0.2ml / gastric administration per 10g body weight respectively.

[0036] Cough test: 1 hour after administration, put the mouse in an inverted 500ml / beaker, and put a cotton ball containing 0.3ml / ammonia water into the beaker at the same time, immediately observe and record the cough latency of the mouse and cough within 3 minutes The number of times, the cough latency and the number of coughs of the mice in each group were counted, compared with the solvent control group, and the inter-group t test was performed.

[0037] The high, middle and low ...

Embodiment 1

[0040] Embodiment 1: the preparation of tablet (unit: kilogram)

[0041] Artemisia annua 950 Honeysuckle 530 Gardenia 335 Scutellaria baicalensis 100 Houttuynia cordata 700,

[0042] The above five flavors, honeysuckle, Artemisia annua, and Houttuynia cordata were soaked in 15 times the amount of water for 3 hours, heated and decocted, and distilled twice for 2 hours each time. At the same time, the volatile oil was collected and set aside. After distillation, the water liquid is concentrated under reduced pressure to a relative density of 1.03-1.08, and the pH value is adjusted to 2.5 with hydrochloric acid to obtain a concentrated solution, which is extracted once with ethyl acetate equal to the concentrated solution, and the extracts are combined, and ethyl acetate is recovered under reduced pressure. Ester, thick paste concentrated to 50 ℃ relative density of 1.10 ~ 1.12, vacuum drying, honeysuckle, Artemisia annua, Houttuynia dry paste powder.

[0043] Take gardenia coar...

Embodiment 2

[0047] Embodiment 2: the preparation of granule dosage form (unit: kilogram)

[0048] Artemisia annua 1050 Honeysuckle 600 Gardenia 370 Scutellaria baicalensis 200 Houttuynia cordata 650,

[0049]The above five flavors, honeysuckle, Artemisia annua, Houttuynia cordata, add 16 times the amount of water, soak for 3 hours, heat and decoct, distill twice, 2 hours each time, collect volatile oil at the same time, and set aside; after distillation, the water is concentrated under reduced pressure to a relative density of 1.03 ~1.08, high-speed centrifugation to take the supernatant, graded ultrafiltration, the ultrafiltrate was concentrated, and dried to obtain honeysuckle, Artemisia annua, and Houttuynia cordata powder.

[0050] Take gardenia coarse powder, heat and reflux with 8 times the amount of 75% ethanol for 3 times, each time for 1 hour, combine the filtrate, filter and concentrate, adjust the pH value to 3.5 with hydrochloric acid, heat, let cool, filter, and concentrate t...

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Abstract

A Chinese-medicinal composition for treating cough and high fever is proportionally prepared from 6 Chinese-medicinal materials including sweet wormwood, honeysuckle flower, capejasmine fruit, scutellaria root, etc. Its preparing process and its application in preparing the medicines for treating cough and high fever are also disclosed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating cough due to lung heat and high fever. Background technique [0002] According to statistics, at least 2 million people in the world die every year due to fever, and the treatment costs are as high as several billion yuan, seriously affecting people's health. Therefore, effectively controlling high fever is an arduous and urgent task for medical workers. [0003] There are many reasons for high fever, such as viral infection, bacterial infection, mycoplasma infection, parasitic infection, etc. Among them, high fever caused by viral and bacterial infection is common. Fever is originally a defense response of the body. It can speed up the metabolic process, promote the growth and reproduction of anti-pathogens, promote the increase of leukocytes, and strengthen the function of the reticuloendothelial system (phago...

Claims

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Application Information

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IPC IPC(8): A61K36/78A61K9/08A61K9/10A61K9/16A61K9/19A61K9/20A61K9/48A61P11/14A61P29/00
Inventor 肖伟戴翔翎凌娅王振中刘涛章晨峰
Owner JIANGSU KANION PHARMA CO LTD
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