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Acetylcysteine or its salt and anti-infectious medicine composition

A technology of acetylcysteine ​​and composition, which is applied in the field of medicine to achieve the effect of simple preparation process, definite curative effect and guaranteed safety

Inactive Publication Date: 2007-10-17
JIANGYIN TIANJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] At present, acetylcysteine ​​or its pharmaceutically acceptable salt and neohouttuydine or its pharmaceutically acceptable salt, 14-dehydroxy-11,12-didehydroandrographolide-3,19- The interaction of one or more of disuccinic acid half ester salts and matrine, compatible prescriptions, used for the treatment of pneumonia, bronchial asthma, chronic obstructive pulmonary disease with acute inflammation of the lungs caused by sensitive bacteria, etc. Drugs for diseases, not yet reported

Method used

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  • Acetylcysteine or its salt and anti-infectious medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Embodiment 1 Preparation of the composition powder injection of the present invention

[0090] 1. Prescription:

[0091]B new composition prescription

[0092] Acetylcysteine ​​100g

[0093] New Houttuyniatin Sodium 20g

[0094] Polysorbate 80 50g

[0095] Mannitol 300g

[0096] Add sterile water for injection to 3000ml

[0097] A total of 1000 sticks were prepared

[0098] Bacterial composition prescription

[0099] Acetylcysteine ​​100g

[0100] Yanhuning 80g

[0101] Mannitol 300g

[0102] Add sterile water for injection to 3000ml

[0103] A total of 1000 sticks were prepared

[0104] Prescription of Bginseng Composition

[0105] Acetylcysteine ​​100g

[0106] Matrine 160g

[0107] Polysorbate 80 50g

[0108] Mannitol 300g

[0109] Add sterile water for injection to 3000ml

[0110] A total of 1000 sticks were prepared

[0111] 2. Specific steps:

[0112] 1) First, aseptically treat the containers used for liquid preparation, antibiotic glass bottle...

Embodiment 2

[0122] Embodiment 2 Preparation of the composition aqueous injection of the present invention

[0123] 1. Prescription:

[0124] B new composition prescription

[0125] Acetylcysteine ​​100g

[0126] New Houttuyniatin Sodium 8g

[0127] Polysorbate 80 30g

[0128] Add water for injection to 5000ml

[0129] A total of 1000 sticks were prepared

[0130] Bacterial composition prescription

[0131] Acetylcysteine ​​100g

[0132] Yanhuning 40g

[0133] Add water for injection to 5000ml

[0134] A total of 1000 sticks were prepared

[0135] Prescription of Bginseng Composition

[0136] Acetylcysteine ​​100g

[0137] Matrine 80g

[0138] Ethanol 80ml

[0139] Add sterile water for injection to 5000ml

[0140] A total of 1000 sticks were prepared

[0141] 2. Specific steps:

[0142] 1) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them with fresh water for injection before use.

[0143] 2) Take 80% of the water for injec...

Embodiment 3

[0152] Embodiment 3 Preparation of the composition sodium chloride infusion of the present invention

[0153] 1. Prescription:

[0154] B new composition prescription

[0155] Acetylcysteine ​​300g

[0156] New Houttuyniatin Sodium 4g

[0157] Polysorbate 80 30g

[0158] Sodium chloride 900g

[0159] Add water for injection to 100000ml

[0160] A total of 1000 bottles were prepared

[0161] Bacterial composition prescription

[0162] Acetylcysteine ​​300g

[0163] Yanhuning 20g

[0164] Sodium chloride 900g

[0165] Add water for injection to 100000ml

[0166] A total of 1000 bottles were prepared

[0167] Prescription of Bginseng Composition

[0168] Acetylcysteine ​​300g

[0169] Matrine 40g

[0170] Sodium chloride 900g

[0171] Add water for injection to 100000ml

[0172] A total of 1000 bottles were prepared

[0173] 2. Specific steps:

[0174] 1) Dispose of the pipes and containers used for liquid preparation the day before, and rinse them with fresh wa...

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Abstract

The present invention belongs to the field of medicine technology and discloses an effective dose containing acetylcysteine or pharmaceutically acceptable salts thereof, and at least one pharmaceutical composition of anti-infective drugs as well as usage and method for making same, wherein the antiinfective drugs are one or several compounds selected from new houttuynine sodium bisulfite or pharmaceutically acceptable salt thereof and / or 14-dehydroxyl-11, 12-dehydro andrographolide-3, 19-di-succinic acid half-ester salts and / or matrine. Said pharmaceutical composition can be made into pharmaceutically acceptable dosage forms and exhibits cooperative building action when being used for diseases such as pneumonia, bronchial asthma, haggis acute inflammation accompanying with chronic emphraxis haggis diseases caused by sensitive bacteria; in addition, possesses excellent stability, exhibits considerably improved effects relative to used individually medicament of the same dose, and results in effects beyond thoughts, possesses wide-ranging applications foreground.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition containing acetylcysteine ​​or a pharmaceutically acceptable salt thereof and at least one anti-infection drug, a preparation method and application thereof, belonging to the technical field of medicine. 2. Background technology [0002] In my country's population statistics, respiratory diseases are the second cause of death, mainly including upper respiratory tract infection, acute and chronic bronchitis, pneumonia, etc. The main symptoms are cough, sputum, and asthma. Most are caused by viral infection, and a few are caused by direct bacterial infection. However, there are not many available drugs in clinical practice and their effects are slow. [0003] Acetylcysteine, which is N-acetyl-L-cysteine. Acetylcysteine ​​is a mucolytic agent, which has a strong effect of dissolving mucus. Viscosity of sputum and liquefaction. Acetylcysteine ​​can also break DNA fibers in purulent sputum, so it c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61K31/365A61K31/198A61K31/185A61K9/00A61K9/08
Inventor 黄振华
Owner JIANGYIN TIANJIANG PHARMA
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