70 results about "AntiInfective Drugs" patented technology

This invention relates to an anti-infective compound, more specifically, 6-fluoro-1-methyl-4-oxo-7-(1-piperazine)-4H-[1, 3] thiazine [3, 2-a] quinoline-3-carboxylic mesylate (compound I), its preparation method and its application. Compound I is prepared by reaction of 6-fluoro-1-methyl-4-oxo-7-(1-piperazine)-4H-[1,3]thiazine[3,2-a]quinoline-3-carboxylic acid and methyl sulfonic acid. Compound I can be used as effective component and mixed with normal pharmaceutical carrier to manufacture anti-infective drug composition, which can be tablets, capsules, granules, injection, eye preparations, ear preparations, gynecological preparations, and external use preparations. Compound I has stable properties, and can be easily dissolved in water, thus can be easily manufactured into various preparations used in clinical treatment. The method has such advantages as simple and reasonable process.

The invention discloses a method for preparing cefixime dispersible tablets, relates to the field of pharmaceutical preparation and particularly relates to cefixime dispersible tablets which are anti-infective agents and the method for preparing the cefixime dispersible tablets. Cefixime serves as an active pharmaceutical ingredient of the cefixime dispersible tablets and auxiliary materials are added in the cefixime dispersible tablets. The auxiliary materials include solubilizing agents, filling agents, lubricating agents, bonding agents and disintegrating agents. The cefixime dispersible tablets include, by weight, 15%-60% of the micronized cefixime, 10%-70% of the filling agents or diluents, 1%-20% of the disintegrating agents, 0.3%-5% of the lubricating agents, 0.5%-10% of the bonding agents and 0.5%-5% of the solubilizing agents, wherein grain diameters of the micronized cefixime range from 20 mu m to 120 mu m. The method has the advantages that the dissolving speed of the cefixime dispersible tablets is rapid and the dissolving is complete.

The invention discloses a halogenated furanone compound and the application thereof in preparing anti-infective drugs. The structural formula of the halogenated furanone compound is indicated by the formula (I), II), (III), (IV), (V), (VI), (VII) or (VIII). The halogenated furanone compound designed and synthesized by the invention has good effect in inhibiting the formation of bacterial biomembranes, can be used as a bacterial biomembrane inhibitor, is separately used or used together with antibiotic drug to overcome the problem of clinical antibiotic resistance.

The invention relates to a 3-aryl-4-(2-glycosyl/amino ethyoxyl)-2(5H)-furanone compound. The 3-aryl-4-(2-glycosyl/amino ethyoxyl)-2(5H)-furanone compound has a structural general formula shown as the specifications. The 3-aryl-4-(2-glycosyl/amino ethyoxyl)-2(5H)-furanone compound has good inhibition effect on staphylococcus epidermidis, Klebsiella pneumonia, novel cryptococcus gattii and the likeand can be used for preparing anti-infective medicaments for treating pneumonia, wound suppuration and the like. The invention discloses a preparation method of the 3-aryl-4-(2-glycosyl/amino ethyoxyl)-2(5H)-furanone compound.

The invention provides a protective repair hydrogel for damaged parts of skin and mucous membranes. The protective repair hydrogel comprises the following components in percentages by weight: 0.5% to10% of a polymer matrix, 0.001% to 0.1% of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 0.001% to 0.1% of N-hydroxysuccinimide, 0.001% to 0.1% of 5'-hydroxydopamine, 0.01% to 5% of a drug for promoting tissue repair, 0.5% to 5% of an anti-infective drug and 80% to 98% of threefold-distilled water. The invention also provides a preparation method of the protective repair hydrogel for damaged parts of skin and mucous membranes, the weight percentages of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, N-hydroxysuccinimide and 5'-hydroxydopamine are optimized, and a layer of protective film can be formed by oxidative crosslinking when the surface of a wound is covered with the protective repair hydrogel, so that the failure of the drug for promoting tissue repair and the anti-infective drug is avoided, and the repair of the wound by the tissue repair drug and the anti-infective drug is also facilitated.

The invention relates to a piperazine urea pleuromutilin derivative and application thereof, belonging to the technical field of antibacterial drugs. The technical problem to be solved by the invention is to provide the piperazine urea pleuromutilin derivative with good antibacterial activity. The structural formula of the piperazine urea pleuromutilin derivative is shown as a formula I in the specification. The piperazine urea pleuromutilin derivative disclosed by the invention is novel in structure and has excellent antibacterial activity. An in-vitro antibacterial experiment obviously showsthat the piperazine urea pleuromutilin derivative has an excellent antibacterial effect on standard drug-resistant staphylococcus aureus strains ATCC33591 and ATCC43300, and on escherichia coli strains ATCC25922 and ATCC25923, is expected to be applied to treatment of bacterial infection caused by staphylococcus aureus and escherichia coli, and provides a new choice for anti-infective drugs.

The invention relates to a rana nigromaculata antimicrobial peptide as well as a gene and application thereof, and belongs to the technical field of biomedicine. The rana nigromaculata antimicrobial peptide is a gene coded single-chain polypeptide separated from an amphibian rana nigromaculata of China, wherein the molecular weight is 1,647.02 Daltons, and the isoelectric point is 11.05; and the complete sequence of the rana nigromaculata antimicrobial peptide is phenylalanine-isoleucine-proline-leucine-valine-serine-glycine-leucine-phenylalanine-serine-arginine-leucine-leucine-glycine-lysine. The coded gene of the rana nigromaculata antimicrobial peptide consists of 316 nucleotides, wherein the mature coded part of the coded gene contains 142nd-186th nucleotides. The artificially synthesized rana nigromaculata antimicrobial peptide has a strong antibacterial effect, has the advantages of high safety, simple sequence and convenience in synthesis, and can be used as a novel anti-infective agent for application.

The invention relates to the antibody engineering and anti-virus medicine fields, and relates to a method for rapid and effective determination of the anti-virus function of recombined human anti-hepatitis B virus antibody. According to the method, settleable virus compound technology is used for establishing a new method for detection and evaluation of anti-virus capability of a molecule. According to the method, the anti-virus and anti-infection capability of the molecule is detected by detection of settleable pathogen compound generation capability of the molecule to be detected, wherein the settleable pathogene compound generation capability of the molecule to be detected is induced in blood serum, and pathogen is virus. The method is used for rapid determination of virus removal and virus infection control capability of an antibody and other anti-infection medicines. The method has the advantages of simple operation process and good result repeatability and is a supplement to the prior art detection and evaluation methods of functions of the anti-virus medicines, and the establishment of the method provides a new choice for research and development of medicines currently having no effective cell and animal infection model virus. The invention also relates to a detection reagent of anti-virus-infection activity, the settleable pathogene compound generated in a detection process and the application of the detection method.

The invention belongs to the field of medical technology, in particular to a guanidyl substitutional tetracycline derivative shown by a general formula (I), wherein R2, R2', R3, R4, R4', R5, R6, R6', R7, R8, R9, r9', R10, R11 and R12 are defined in an instruction book; the invention further relates to a preparation method of compounds, and medicine composites containing the compounds and the application of the compounds to treating and/or preventing tetracyclines sensitive diseases, particular for the application of anti-infective drugs.

The invention discloses a didemethylated actinomycin derivative and an application thereof in preparation of drugs for resisting drug-resistant bacteria infection. The structural formula of the actinomycin double-demethylation derivative Didemactinomycin D is as shown in a formula (I), and the structural formula of the Didemactinomycin X2 is as shown in a formula (II). The actinomycin demethylation derivatives Didemactinomycin D and Didemactinomycin X2 having drug-resistant staphylococcus aureus resistance are separated from a transmethylase inactivated mutant strain ZS0073/delta acnM of a marine-derived actinomycin D production strain S.costaricaus SCSIO ZS0073. The test results show that the Didemactinomycin D has good inhibitory activity (MIC is 4-32 [mu] g/mL) on 14 strains of staphylococcus aureus, compared with actinomycin D, the toxicity to normal human cells is greatly weakened, and the Didemactinomycin D has important value in development of anti-infective drugs.

The invention discloses blunt snout bream beta-defensin gene, which has a nucleotide sequence represented by SEQ ID NO:1. The invention further discloses recombinant protein encoded by the blunt snout bream beta-defensin gene, and a preparation method thereof, wherein the recombinant protein has an amino acid sequence represented by SEQ ID NO:2. The blunt snout bream beta-defensin recombinant protein provides good bacterial inhibition activities for staphylococcus aureus, streptococcus, ampicillin resistance type escherichia coli, aeromonas hydrophila and the like, and provides a class of new drugs with good therapeutic effects for anti-infective drugs and drug-resistant bacteria. The preparation method for the blunt snout bream beta-defensin recombinant protein has the following advantages that: high purity products can be easily obtained; and compared to the existing chemical synthesis method, the method of the present invention has characteristics of good activity, cost reduction, preparation time shortening, and easy industrial production achievement.

The invention relates to a 3D printing titanium interbody fusion cage as well as a preparation method and an application thereof. The 3D printing titanium interbody fusion cage comprises a Ti6Al4V main body structure and a medicine coating coated on the surface of the main body structure, and the medicine coating comprises a biodegradable high polymer material and an anti-infective drug. Accordingto the 3D printing titanium interbody fusion cage disclosed by the invention, the surface of the main body structure made of a Ti6Al4V material is creatively coated with the medicine coating containing the biodegradable high polymer material and the anti-infective drug, the interbody fusion cage is good in biocompatibility, local postoperative infection can be well prevented by locally releasingthe medicine after the interbody fusion cage is implanted into a focus part, the postoperative infection occurrence rate is greatly reduced, and interbody fusion is assisted.

The invention belongs to the technical field of medicine, and particularly relates to application of hypoxanthine nucleotide in preparation of anti-infective drugs. Experiments prove that the hypoxanthine nucleotide can significantly improve the sensitivity of Escherichia coli, Klebsiella pneumoniae, staphylococcus aureus multi-drug-resistant bacteria, pseudomonas aeruginosa and other bacteria toamoxicillin, cefoperazone, meropenem, gentamicin and other antibiotics, so that the hypoxanthine nucleotide can be used as an anti-infective drug together with antibiotics. Bacteria are killed under the condition of low-concentration antibiotics, a good anti-infection effect is achieved, and meanwhile bacterial drug resistance is reduced.

An oxazolidinone-alkyl amine group-furanone type compound has the flowing general molecular formula. The compound has the better inhibiting effect on staphylococcus epidermidis, klebsiella pneumoniae, cryptococcus neoformans and the like, and can be used for preparing anti-infective drugs for treating intestinal infection, pneumonia, wound suppuration and the like. The invention discloses a preparation method of the compound.

Compounds useful as HCV anti-infectives having the formula: wherein the formula variables are as defined herein, are disclosed. Also disclosed are methods of making and using the same.

The invention provides an anti-infective drug, the structure of which is shown as a formula I. The anti-infective drug provided by the invention comprises a stereoisomer, a hydrate, a deuterated substance, an ester, a solvate, a crystal form, a metabolite, and a pharmaceutically acceptable salt or a prodrug, and has stronger bacterial activity and a wider antibacterial spectrum so as to treat infectious diseases.

The invention relates to a new application of exosome secreted by cells, and relates to a preparation method of the exosome and an application of the exosome to treatment of infectious related diseases after being wrapped with antibacterial drugs. Compared with the prior art, the exosome is used as an antibacterial drug carrier, so that the biological effect of the antibacterial drug can be improved, and the effect of the antibacterial drug in the aspect of treating refractory infectious related diseases is enhanced.

The invention discloses an antibacterial peptide LJ-2 and an application thereof. The amino acid sequence of the antibacterial peptide LJ-2 is as follows: the amino acid sequence of the antibacterialpeptide LJ-2 is shown in the specification: arginine, arginine, valine, leucine, arginine, isoleucine, leucine, lysine, histidine, histidine, glutamine, glycine, leucine, isoleucine, arginine, asparagine, leucine and leucine; the antibacterial peptide LJ-2 has good antibacterial activity on gram-positive bacteria, gram-negative bacteria and fungi, and has the advantages of low hemolysis, heat resistance, salt resistance, acid and alkali resistance and repeated freeze thawing resistance. Therefore, the antibacterial peptide LJ-2 disclosed by the invention has a wide application prospect in thefields of anti-infective drug preparation, animal husbandry development, human disease prevention and treatment, food preservation, detergents, cosmetics and the like.

The invention discloses Calpain-1 and application thereof in inhibiting porcine epidemic diarrhea virus infection, and belongs to the technical field of biological engineering. On the basis of finding that pig small intestine mucus total protein can inhibit PEDV infection, the proteinase-1 capable of inhibiting PEDV invasion into host cells is obtained through identification and purification from pig small intestine mucus, the nucleotide sequence of the protein coding gene is as shown in SEQ ID No.1 in a sequence table, and the amino acid sequence of the protein coding gene is as shown in SEQ ID No.2. The porcine calpain protein-1 further obtained through eukaryotic expression also has a remarkable antiviral function, and the porcine calpain protein-1 is mainly used for inhibiting PEDV from invading host cells through enzymolysis of PEDV spike protein. The Calpain-1 disclosed by the invention can also be applied to the preparation of PEDV infection resisting medicines or antiviral feed additives.