Protective repair hydrogel for damaged parts of skin and mucous membranes and preparation method thereof

A protective and water repair technology, applied in medical science, bandages, etc., can solve the problems of inevitable bacteriostatic agents and human epidermal growth factor oxidation failure, and achieve the effect of being conducive to repair, avoiding failure, and promoting failure.

Active Publication Date: 2020-06-19
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sodium hyaluronate is used as a humectant in the gel to avoid dehydration of the gel, but it still exposes the bacteriostatic agent and human epidermal growth factor to the air, which inevitably causes the oxidation of the bacteriostatic agent and human epidermal growth factor fail

Method used

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  • Protective repair hydrogel for damaged parts of skin and mucous membranes and preparation method thereof
  • Protective repair hydrogel for damaged parts of skin and mucous membranes and preparation method thereof
  • Protective repair hydrogel for damaged parts of skin and mucous membranes and preparation method thereof

Examples

Experimental program
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preparation example Construction

[0052] The present invention also provides a method for preparing a protective repairing hydrogel for damaged parts of the skin and mucous membranes, comprising the following steps:

[0053] Step 1: dissolving the polymer matrix in triple distilled water to obtain an aqueous solution of the polymer matrix with a mass volume ratio of 0.5% to 5%;

[0054] Step 2: Add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide respectively to the polymer matrix aqueous solution, and react for 30-40 minutes ;

[0055] Step 3: continue to add 5'-hydroxydopamine, and adjust the pH to 4-5, and react overnight;

[0056] Step 4: dialyzing the reaction product obtained in the step 3 in an acidic phosphate buffered saline solution, the pH of the acidic phosphate buffered saline solution is 4-5;

[0057] Step 5: Add tissue repair-promoting drugs and anti-infective drugs to the dialysis product, mix evenly, and freeze-dry to make powder;

[0058] Step 6: Dissolv...

Embodiment 1

[0070] The protective repairing hydrogel used in damaged skin and mucous membranes provided by this embodiment includes the following components in percentage by weight: polymer matrix (hyaluronic acid) 0.5%; 1-(3-dimethylammonia Propyl)-3-ethylcarbodiimide hydrochloride; N-hydroxysuccinimide; 5'-hydroxydopamine; promoting tissue repair drugs (fibroblast growth factor) 0.01%; anti-infective drugs (antiviral drugs Arbidol) 0.5%; triple distilled water 80%.

[0071] The 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (w h ), N-hydroxysuccinimide (w N ) and the 5′-hydroxydopamine (w d ) with a mass ratio of 1:1:1, and the weight percentage of the N-hydroxysuccinimide w N Satisfy:

[0072]

[0073] The preparation process includes:

[0074] Step 1: Dissolving hyaluronic acid in triple distilled water to obtain a hyaluronic acid aqueous solution with a mass volume ratio of 0.5%;

[0075] Step 2: Add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride an...

Embodiment 2

[0081] The protective repairing hydrogel used in damaged skin and mucous membranes provided by this embodiment includes the following components in percentage by weight: polymer matrix (alginic acid) 1%; 1-(3-dimethylaminopropyl base)-3-ethylcarbodiimide hydrochloride; N-hydroxysuccinimide; 5′-hydroxydopamine; promoting tissue repair drugs (epidermal growth factor) 0.05%; anti-infective drugs (antibacterial drugs Cephalosporin Vegetables) 0.9%; triple distilled water 82%.

[0082] The 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (w h ), N-hydroxysuccinimide (w N ) and the 5′-hydroxydopamine (w d ) with a mass ratio of 1:1:1, and the weight percentage of the N-hydroxysuccinimide w N Satisfy:

[0083]

[0084] The preparation process includes:

[0085] Step 1: Dissolving alginic acid in triple distilled water to obtain an aqueous solution of alginic acid with a mass volume ratio of 1%;

[0086] Step 2: Add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hyd...

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Abstract

The invention provides a protective repair hydrogel for damaged parts of skin and mucous membranes. The protective repair hydrogel comprises the following components in percentages by weight: 0.5% to10% of a polymer matrix, 0.001% to 0.1% of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 0.001% to 0.1% of N-hydroxysuccinimide, 0.001% to 0.1% of 5'-hydroxydopamine, 0.01% to 5% of a drug for promoting tissue repair, 0.5% to 5% of an anti-infective drug and 80% to 98% of threefold-distilled water. The invention also provides a preparation method of the protective repair hydrogel for damaged parts of skin and mucous membranes, the weight percentages of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, N-hydroxysuccinimide and 5'-hydroxydopamine are optimized, and a layer of protective film can be formed by oxidative crosslinking when the surface of a wound is covered with the protective repair hydrogel, so that the failure of the drug for promoting tissue repair and the anti-infective drug is avoided, and the repair of the wound by the tissue repair drug and the anti-infective drug is also facilitated.

Description

technical field [0001] The invention relates to the technical field of biomaterials, more specifically, the invention relates to a protective repairing hydrogel for skin and mucous membrane damage and a preparation method thereof. Background technique [0002] In daily life, contusions, abrasions, scratches, cuts and other skin injuries often occur. In order to make the wound repair faster, repair hydrogel is often applied to the wound. [0003] Chinese invention patent 201710752030.1 discloses a hydrogel for repairing tissue damage and its preparation method. PGE2 powder is dissolved in phosphate buffer to make a PGE2 solution, which is added dropwise to the hydrogel and stored at 2-8°C or Freeze at -18--22°C, and the hydrogel material is at least one of chitosan, collagen, hyaluronic acid and fibrin. The hydrogel can prolong the release time of PGE2 to a certain extent, which can be directly used in the treatment of tissue damage and promote the recovery of damaged skin ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0014A61L26/0023A61L26/0066A61L26/008
Inventor 陶娟朱锦涛杜虹瑶张连斌柳佩
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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