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3D printing titanium interbody fusion cage and preparation method and application thereof

An intervertebral fusion device and 3D printing technology, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of inability to reduce the incidence of postoperative infection and poor coating stability, and achieve the prevention of local postoperative infection, structure The effect of stabilizing and reducing the incidence of postoperative infection

Active Publication Date: 2020-03-31
中国人民解放军总医院第八医学中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional intervertebral fusion cages cannot prevent local postoperative infection well, and cannot reduce the incidence of postoperative infection, and because the intervertebral fusion cage requires load bearing and slight movement, the coating attached to it is less stable

Method used

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  • 3D printing titanium interbody fusion cage and preparation method and application thereof
  • 3D printing titanium interbody fusion cage and preparation method and application thereof
  • 3D printing titanium interbody fusion cage and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0059] This embodiment provides a 3D printing titanium intervertebral fusion device, the 3D printing titanium intervertebral fusion device includes Ti 6 Al 4 V main structure and a drug coating coated on the surface of the main structure; the drug coating includes biodegradable polymer material polyvinyl alcohol (molecular weight 75000Da) and anti-infection drug vancomycin hydrochloride. The main body has a porous structure with an average pore diameter of 420 μm and a porosity of 70%. The mass ratio of polyvinyl alcohol to vancomycin hydrochloride is 3:1, and the load of the drug coating on the main structure is 1.0%.

[0060] Its preparation method comprises the following steps:

[0061] (1) The entity is designed by UG NX6.0 software, and the design model is obtained by 3-matic grid processing. 6 Al 4 V is the main material and is 3D printed with Acram Q10 equipment using metal electron beam melting technology. The electron beam output power is 3kW, the printing accurac...

Embodiment 2

[0066] This embodiment provides a 3D printing titanium intervertebral fusion device, the 3D printing titanium intervertebral fusion device includes Ti 6 Al 4 V main structure and a drug coating coated on the surface of the main structure; the drug coating includes biodegradable polymer material polylactic acid-glycolic acid copolymer (molecular weight 20000Da) and anti-infection drug levofloxacin hydrochloride. The main body has a porous structure with an average pore size of 400 μm and a porosity of 65%. Wherein the mass ratio of polylactic acid-glycolic acid copolymer to levofloxacin hydrochloride is 1:1, and the load of the drug coating on the main structure is 0.5%.

[0067] Its preparation method comprises the following steps:

[0068] (1) The entity is designed by UG NX6.0 software, and the design model is obtained by 3-matic grid processing. 6 Al 4 V is the main material and is 3D printed with Acram Q10 equipment using metal electron beam melting technology. The out...

Embodiment 3

[0073] This embodiment provides a 3D printing titanium intervertebral fusion device, the 3D printing titanium intervertebral fusion device includes Ti 6 Al 4 V main structure and a drug coating coated on the surface of the main structure; the drug coating includes biodegradable polymer material polyvinyl alcohol (molecular weight 79000Da) and anti-infection drug vancomycin hydrochloride. Wherein the mass ratio of polyvinyl alcohol to vancomycin hydrochloride is 5:1, and the load of the drug coating on the main structure is 1.5%.

[0074] Its preparation method comprises the following steps:

[0075] (1) The entity is designed by UG NX6.0 software, and the design model is obtained by 3-matic grid processing. 6 Al 4 V is the main material and is 3D printed with Acram Q10 equipment using metal electron beam melting technology. The output power of the electron beam is 2kW, the printing accuracy is ±0.4mm, and the layer thickness is 0.05mm. Ti 6 Al 4 V main structure;

[0076...

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Abstract

The invention relates to a 3D printing titanium interbody fusion cage as well as a preparation method and an application thereof. The 3D printing titanium interbody fusion cage comprises a Ti6Al4V main body structure and a medicine coating coated on the surface of the main body structure, and the medicine coating comprises a biodegradable high polymer material and an anti-infective drug. Accordingto the 3D printing titanium interbody fusion cage disclosed by the invention, the surface of the main body structure made of a Ti6Al4V material is creatively coated with the medicine coating containing the biodegradable high polymer material and the anti-infective drug, the interbody fusion cage is good in biocompatibility, local postoperative infection can be well prevented by locally releasingthe medicine after the interbody fusion cage is implanted into a focus part, the postoperative infection occurrence rate is greatly reduced, and interbody fusion is assisted.

Description

technical field [0001] The invention belongs to the technical field of bone implant materials, in particular to a 3D printed titanium intervertebral fusion device and its preparation method and application, in particular to a 3D printed titanium intervertebral fusion device capable of preventing postoperative infection and its preparation method and application. Background technique [0002] Implant-related infection is difficult to manage because it requires long-term antibiotic treatment and even revision surgery. Implants can counteract host immune defenses through biofilm formation, immune evasion, and antimicrobial resistance. Surgical site infections (SSIs) are among the most serious postoperative complications. Especially in recent years with the introduction of intervertebral fusion devices, the incidence of infection in intervertebral fusion surgery has been greatly improved. Spine surgery SSIs can be one of the most serious complications after spinal interbody f...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/34A61L27/50A61L27/54A61L27/56A61L27/58
CPCA61L27/06A61L27/34A61L27/50A61L27/56A61L27/54A61L27/58A61L2430/38A61L2300/406A61L2300/606C08L29/04
Inventor 崔旭李渊李力韬
Owner 中国人民解放军总医院第八医学中心
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