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Triple natural polymer viscoelastic composition

A natural polymer and composition technology, applied in tissue regeneration, drug delivery, surgical adhesives, etc., can solve the problems of delayed onset of action, short action time, poor absorption, etc., to promote cartilage formation and repair, and reduce side effects , the effect of good patient compliance

Inactive Publication Date: 2007-10-31
ALCON INC
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, oral dosage forms of GS and CS have disadvantages of poor absorption, delayed onset of action, and short duration of action

Method used

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  • Triple natural polymer viscoelastic composition

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Embodiment Construction

[0018] Although of particular importance in ophthalmic surgery, and cataract surgery in particular, the methods and compositions of the present invention can be used in any viscous surgical procedure and hyaluronic acid-based viscoelastic material. In cataract surgery, the anterior chamber, the space between the iris and the corneal endothelium, is filled with a viscoelastic material. The viscoelastic material serves two purposes: (1) to maintain the hemispherical shape of the cornea, allowing the surgeon an unobstructed view of the internal surgical site, and (2) to protect the delicate endothelium in the cornea by covering it. As noted above, prior art viscoelastic agents do not provide analgesic or anti-inflammatory effects, with the result that topical agents must be used to control pain and inflammation pre- and post-operatively. Therefore, it would be preferable if the traditional viscoelastic functions and analgesic and anti-inflammatory functions could be performed by ...

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Abstract

A triple natural polymer viscoelastic composition is disclosed. By combining glucosamine sulfate (''GS''), sodium hyaluronate (''HA'') and chondroitin sulfate (''CS''), the triple natural polymer viscoelastic compositions of this invention can provide a viscoelastic agent at a surgical site that not only serves as a protective agent to ocular tissues, but that can also act as an agent to alleviate pain and inflammation associated with ocular surgery. Embodiments of this invention can comprise GS combined with existing HA / CS viscoelastic agents. Embodiments of this invention can also comprise GS and CS in combination with an irrigation solution. Further, to enhance retention time at the site of an intra-articulate application of an embodiment of this invention, the following biodegradable polymers may also be included in an embodiment of the compositions of the present invention: cellulose derivatives (e.g., hydroxypropylmethylcellulose, ethylcellulose, caboxymethylcellulose, etc.), carbopol, citosan, and collagen.

Description

technical field [0001] This application claims priority under 35 U.S.C. §119 to U.S. Provisional Patent Application No. 60 / 630,584, filed November 23, 2004, the entire contents of which are hereby incorporated by reference. [0002] The present invention relates to novel viscoelastic compositions and their use in the field of surgery utilizing viscous and / or viscoelastic materials (also known as viscosurgery). In particular, the invention relates to the combination of polymeric materials in aqueous solutions to enhance the performance of viscous surgical materials, particularly in certain environments. The present invention also relates to methods of using such enhanced viscoelastic materials, and similarly enhanced irrigation solutions for all conventional purposes, and especially those applications where retention of the viscoelastic material is desired, such as in joints and in some Methods used in ophthalmic surgical procedures. Background technique [0003] Viscous or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/728A61K31/726A61K47/36
CPCA61K9/0019A61K31/737A61K9/0048A61K31/728A61K9/0024A61K47/36A61L24/0031A61L2430/16A61K31/7008A61L24/043C08L5/08A61K9/08A61K31/726
Inventor M·R·贾法里K·L·马克沃尔特A·L·韦纳
Owner ALCON INC
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