Medicinal composition containing dalbergia and storax, preparation method and preparation

The technology of a composition and styrax is applied in the directions of drug combinations, medical preparations containing active ingredients, and medical preparations with non-active ingredients, etc., and can solve the problems of less variety of membrane materials, inability to work normally, and shortened service life.

Active Publication Date: 2007-12-12
TIANJIN TASLY PHARMA CO LTD
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

[0007] (1) The composition of Chinese herbal medicine is complex, especially in many compound preparations, the active ingredients are not fully clear, so it is necessary to carry out very in-depth research before applying ultrafiltration technology to Chinese herbal medicine preparations
For example, due to the complexity of the ingredients, it is impossible to apply ultrafiltration to the production of most traditional Chinese medicine preparations before a large number of pharmacological and clinical research tests are conducted to fully evaluate the effect of ultrafiltration on the efficacy of each ingredient in traditional Chinese medicine preparations.
[0008] (2) There are few types of membrane materials, the membrane pore size distribution is wide, and the performance is not stable
Hydrophilic membrane materials such as cellulose acetate and sulfonated polysulfone have less adsorption of solutes and a smaller molecular weight cut-off, but poor thermal stability, mechanical strength, chemical resistance, and bacterial erosion resistance are usually not high; polysulfone and other hydrophobic Membrane material has high mechanical strength, high temperature resistance, solvent resistance, and biodegradation resistance, but because the molecular chain contains a large number of hydrophobic genes or chain links, and has a lot of electrostatic charges, the membrane has a low water permeability and low anti-pollution ability
[0009] (3) Membrane fouling is the biggest obstacle preventing ultrafiltration technology from laboratory research to industrial application stage
In the ultrafiltration process of traditional Chinese medicine preparations, if the pretreatment effect of the liquid medicine is not good, the membrane surface will be easily polluted and the membrane pores will be blocked, which will reduce the permeation flux, that is, the productivity, or even fail to work normally, reduce the production efficiency, and increase the cost, resulting in membrane shortened service life
[0010] (4) The selection method of membrane modules has not yet been established, and the operating parameters of ultrafiltration still need to be optimized
[0011] Regarding the practical application of compound Danshen tablets prepared by ultrafiltration, there are no reports in the current literature

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] The raw materials are 450g of salvia miltiorrhiza, 141g of notoginseng, 8g of balsamic oil, and 50g of safflower.

[0073] Extract the salvia miltiorrhiza and safflower with ethanol to obtain the ethanol extract of the salvia miltiorrhiza and safflower, filter the extract with gauze, and collect the filtrate. The filtrate was ultrafiltered with a cellulose diacetate membrane with a molecular weight cut-off of 6000, and the filtration method was cross-flow filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.1Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.5kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are used, and the pressure fluctuation difference is 0.1Mpa. The flow rate of the feed l...

Embodiment 2

[0076] The raw materials are 558g of Salvia miltiorrhiza, 34g of notoginseng, 8g of balsamic oil, and 72g of safflower.

[0077] Extracting the salvia miltiorrhiza and safflower with ethanol to obtain the ethanol extract of the salvia miltiorrhiza and safflower, performing microfiltration with a ceramic membrane, and collecting the filtrate. The filtrate was ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 80,000, and the filtration method was dead-end filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.5Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.25kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The f...

Embodiment 3

[0080] The raw materials are 360g of Salvia miltiorrhiza, 232g of notoginseng, 8g of balm oil, and 24g of safflower.

[0081] Extracting Danshen, Panax notoginseng and safflower with ethanol to obtain a mixed ethanol extract, centrifuging the extract at high speed and then separating the supernatant. The liquid is ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 50,000, and the filtration method adopts cross-flow filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.35Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.20kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 3.0m / s. ...

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Abstract

The invention discloses a Chinese medicinal composition for treating coronary disease, which is prepared from raw material herbs of root of red rooted saliva, notoginseng, rosewood oil and safflower or salvia miltiorrhizae, notoginseng, liquidambar orientalis mill and safflower, and the preparation process comprises the steps of mixing red-rooted salvia, notoginseng, safflower to obtain water extract or alcohol extract, subjecting the extract to preliminary settlement treatment, further subjecting the extract to ultrafiltration treatment, concentrating the ultrafiltrate, charging rosewood oil or liquidambar orientalis mill, and producing preparation through the conventional process.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition prepared by an ultrafiltration process. Specifically, the invention relates to a traditional Chinese medicine composition for treating coronary heart disease prepared by ultrafiltration. Background technique [0002] Compound Danshen Tablet is a variety recorded in the Chinese Pharmacopoeia. It has the effects of promoting blood circulation and removing blood stasis, regulating qi and relieving pain. It is commonly used clinically for chest tightness and angina pectoris. The traditional process is: take Salvia miltiorrhiza and extract 3 times, add ethanol to reflux for 1.5 hours for the first time, filter, recover ethanol from the filtrate, concentrate to a relative density of 1.30 (55-60°C); add 50% ethanol for the second time and reflux for 1.5 hours , filtered. For the third time, add water and reflux for 2 hours, filter, combine the second and third filtrates, recover ethanol, co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/20A61K47/36A61P9/10
Inventor 李旭郑永锋范立君
Owner TIANJIN TASLY PHARMA CO LTD
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