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Fibre connexin active tears and production method thereof

A technology of fibronectin and activity, applied in the direction of organic active ingredients, inorganic active ingredients, peptide/protein ingredients, etc., can solve the problems of aggravating dry eye disease, unfavorable treatment of eye diseases, etc., and achieve the effect of improving stability

Active Publication Date: 2008-01-02
郑州弗博瑞生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The long-term use and abuse of antibiotics is not only not conducive to the treatment of eye diseases, but also aggravates the condition of dry eye

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Fibronectin active tears are composed of the following components in proportion: 0.8g hydroxyethyl cellulose, 0.4g carbomer, 0.35g boric acid, 0.8g sodium chloride, 0.15g potassium chloride, 0.003g magnesium chloride, Fibronectin 0.08g, adjust the pH to 6.5-7.0 with sodium bicarbonate, add purified water to 100ml.

[0037] The production method is as follows: After completely dissolving hydroxyethyl cellulose and carbomer with appropriate amount of water (purified water), filter. Another sodium chloride, potassium chloride, magnesium chloride and boric acid were dissolved in an appropriate amount of hot water (purified water), and filtered. After mixing the two, use sodium bicarbonate to adjust the pH to 6.5-7.0, add pure water to the set volume, carry out pasteurization, add fibronectin according to the formula amount after cooling, and perform microfiltration for secondary removal after magnetic stirring. Bacteria, aseptic subpackage to obtain the product.

Embodiment 2

[0039] The fibronectin-activated tears of the present invention can also be composed of the following components in proportions: 0.4 g of hydroxyethyl cellulose, 0.6 g of carbomer, 0.2 g of polyvinyl alcohol, 0.4 g of boric acid, and 0.8 g of sodium chloride , potassium chloride 0.2g, magnesium chloride 0.005g, fibronectin 0.1g, adjust the pH to 6.5-7.0 with sodium bicarbonate, add purified water to 100ml.

[0040] The production method is as follows: hydroxyethyl cellulose, carbomer, polyvinyl alcohol and appropriate amount of water (purified water) are completely dissolved, and then filtered. Another sodium chloride, potassium chloride, magnesium chloride and boric acid were dissolved in an appropriate amount of hot water (purified water), and filtered. After mixing the two, use sodium bicarbonate to adjust the pH to 6.5-7.0, add pure water to the set volume, carry out pasteurization, add fibronectin according to the formula amount after cooling, and perform microfiltration ...

Embodiment 3

[0042] Following formula also can reach the object of the present invention: hydroxyethyl cellulose 0.4g, polyvinyl alcohol 0.6g, boric acid 0.4g, sodium chloride 0.8g, potassium chloride 0.2g, magnesium chloride 0.005g, fibronectin 0.1g , adjust the pH to 6.5-7.0 with sodium bicarbonate, and add purified water to 100ml.

[0043]The production method is as follows: after completely dissolving hydroxyethyl cellulose, polyvinyl alcohol and appropriate amount of water (purified water), filter. Another sodium chloride, potassium chloride, magnesium chloride and boric acid were dissolved in an appropriate amount of hot water (purified water), and filtered. After mixing the two, use sodium bicarbonate to adjust the pH to 6.5-7.0, add pure water to the set volume, carry out pasteurization, add fibronectin according to the formula amount after cooling, and perform microfiltration for secondary removal after magnetic stirring. Bacteria, aseptic subpackage to obtain the product.

[00...

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PUM

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Abstract

The invention relates to a fibronectin active tear and the method for preparing the same, which is characterized in that it comprises humectant composed of fibronectin, high polymer compound and metallic hydrochlorate. The fibronectin active tear belongs to cytokine active tear, contains biological active substance extracted from animal body. It is a compound composed of several non-toxic high polymers. The lubricating effect is good, the viscosity and water retention is proper and contains no antibiotics medicine. So it is and ideal for ophthalmocace such as xeroma, ceratitis and conjunctivitis, and is favorable for eye health care.

Description

technical field [0001] The invention relates to an ophthalmic liquid, in particular to a fibronectin active tear, which is mainly used for dry eye, keratitis, conjunctivitis and other ophthalmic diseases, and contains a bioactive component fibronectin (FN). Background technique [0002] Dry eye syndrome has become one of the most common ocular surface diseases in recent years. It usually manifests as eye fatigue, foreign body sensation, dryness, burning sensation, soreness, accompanied by itchy eyes, photophobia, blurred vision and eye congestion. If it is dry for a long time without effective treatment, corneal and conjunctival keratinization, ulcers, scars, etc. will be formed, resulting in decreased vision, and in severe cases, there is a risk of blindness. With the popularization and development of computers and networks, the prevalence rate is increasing year by year, and the tendency of patients to younger age is very obvious, which seriously affects people's work effi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61P27/04A61K31/717A61K31/765A61K33/10A61K33/14A61K33/22A61K33/30
Inventor 吴学军王斌王章存
Owner 郑州弗博瑞生物技术有限公司
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