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Method for preparing plant sterol-cyclodextrin inclusion compound

A cyclodextrin inclusion complex, phytosterol technology, applied in food preparation, food science, application and other directions, can solve the problems of opacity, poor sensory quality, serious taste, etc., to improve solubility, increase oxidation stability, improve effect of taste

Inactive Publication Date: 2008-01-16
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned patents also have many studies on improving the dispersion of the water phase, they are mainly based on the characteristics of emulsification dispersion and co-solubility. This type of product is used in low-fat or fat-free beverages such as turbid beverages, milk beverages, soybean milk, and emulsified concentrated fruit juices. It is suitable for food, but the product is emulsified and opaque, and the product has a serious lime flavor and powdery taste, and the sensory quality of the product is not good

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0024] Before the experiment, the sterol raw material was placed in an oven and dried overnight at 60 °C. Weigh 8.4g of mixed phytosterol PS (including sitosterol, stigmasterol, campesterol, brassicasterol), in a 500mL beaker, add anhydrous ethanol that is 30 times the mass of sterols preheated to 50°C, and place in a 50°C water bath Keep warm and stir to dissolve. Then, add 30g of hydroxypropyl cyclodextrin (HP-CD, PS molar ratio is about 2:1), stir at a medium speed to dissolve, and then magnetically stir (50r / m) to fully form sterol-hydroxypropyl cyclodextrin clathrate. After stirring for 12 hours, cool to 4°C and keep warm for 12 hours, the crystals are fully separated, and the crystals are collected by cold filtration, about 15.2g. The crystallized mother liquor was concentrated in vacuo (0.01Mpa, 30°C) to remove ethanol to obtain about 23.2g of white solid powder. Combine the crystals and powder to obtain the total sterol-hydroxypropyl cyclodextrin inclusion compound....

example 2

[0027] Weigh 8.4g of mixed phytosterol PS (including sitosterol, stigmasterol, campesterol, brassicasterol) which has been pre-dried at 60°C overnight, and add 15 times the mass of sterol preheated to 30°C in a 500mL beaker. Anhydrous n-butanol, keep warm in a water bath, stir to dissolve. Then, add 130g of hydroxypropyl cyclodextrin (HP-CD, PS molar ratio is about 5:1), stir at a medium speed to dissolve, and then magnetically stir (30r / m) to fully form sterol-hydroxypropyl cyclodextrin clathrate. After stirring for 24 hours, cool to 0°C and keep warm for 12 hours, the crystals are fully separated, and the crystals are collected by cold filtration, about 42.4g. The crystallized mother liquor was concentrated in vacuo (0.01Mpa, 70°C) to remove butanol to obtain about 95g of white solid powder. Subsequent operations and product analysis are the same as Example 1. The results are as follows: the inclusion rate of sterols is 96.2%, the inclusion efficiency is 18.6% (mol / mol, 10...

example 3

[0029]Weigh 4.2g of mixed phytosterol PS (including sitosterol, stigmasterol, campesterol, brassicasterol) pre-dried overnight at 60°C, and add 80 times the mass of sterols preheated to 70°C to a 500mL beaker. Absolute ethanol, keep warm in a water bath, stir to dissolve. Then, add 12g of β-cyclodextrin (the molar ratio of β-CD and PS is about 1:1), stir at a medium speed to dissolve, and then stir magnetically (100r / m) to fully form the sterol-β-CD inclusion complex. After stirring for 5 hours, cool to 4°C, keep warm for 12h, concentrate in vacuo (0.01Mpa, 50°C) to remove ethanol, and obtain about 15.8g of white solid powder. Subsequent operations and product analysis are the same as Example 1. The results are as follows: the inclusion rate of sterols is 68.2%, the inclusion efficiency is 70.8% (mol / mol, 100%), and the solubility (water) of the resulting product is 15.2%.

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Abstract

The invention relates to a preparation method of plant sterol cyclodextrin inclusion complex, which is characterized in that: firstly, dried plant sterol is added into the preheating anhydrous solvent of 25 DEG C to 90 DEG C for being dissolved; after being dissolved by adding solubilizer, the anhydrous solvent is blended in the speed of 30 to 100 r / m for 2 to 24 hours, and is cooled to 0 DEG C to 4 DEG C, and then is implemented with heat preservation for being crystallized and separated out, afterwards, which is filtered; the crystal and crystal liquor are separated; thereby the crystal is the plant sterol cyclodextrin inclusion complex. The solubilizer can be Beta-cyclodextrin, decoration of Beta-cyclodextrin, Beta-hydroxypropyl Cyclodextrin and the mixer of Beta-cyclodextrin in any proportion; the quantity relative ratio of the Beta-cyclodextrin and the plant sterol feeding material is 1 to 5:1; the mass ratio of the anhydrous solvent and the plant sterol cyclodextrin is 15 to 100:1. The water-solubility of plant sterol is added in the invention, thereby the taste and appearance of the plant sterol are improved; the plant sterol can be applicable for various food, in particular to clarifying beverages, jams and other food with clarifying and transparent appearance.

Description

technical field [0001] The invention relates to a preparation method of a phytosterol-cyclodextrin inclusion compound. Background technique [0002] As we all know, cardiovascular and cerebrovascular diseases are the number one killer of human health, and high blood cholesterol is the most important risk factor for cardiovascular and cerebrovascular diseases. Therefore, blocking or reducing the absorption of cholesterol has become an effective way to prevent and treat cardiovascular and cerebrovascular diseases. Numerous clinical experiments have proved that phytosterols can significantly reduce the absorption of cholesterol and play a role in lowering blood cholesterol. Because it is derived from natural vegetable oil by-products, it has high safety (approved by the FDA as a GRAS substance in 1998), and is especially suitable for patients with mild hypercholesterolemia or added to food as a functional factor for the prevention of ordinary people. In addition, phytosterols...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/29A23L1/30A23L33/11
Inventor 孟祥河潘秋月孙培龙邵平
Owner ZHEJIANG UNIV OF TECH
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