The invention discloses litchi wine with effects of nourishing yin and decreasing internal heat and a preparation method of the litchi wine. The litchi wine is prepared from the following raw materials in part by weight: 150-160 parts of litchi, 3-4 parts of roasted barley tea, 5-6 parts of cherry tomatoes, 2-3 parts of mung bean flour, 2-3 parts of cedrela sinensis, 1-2 parts of rosa laevigata michx, 1-2 parts of anemarrhenae, salt, cane sugar, tartaric acid, pectinase, DV10 yeast, macroporous resin, glutamate, chitosan and a defined amount of water. The roasted barley tea and the cedrela sinensis are parched in a mixed manner, and taste of the roasted barley tea and taste of the cedrela sinensis are mixed, so that the litchi wine is unique and delicious; the cherry tomatoes and the mung bean flour are mixed and pulped, nutrition is improved, the litchi wine tastes sour and sweet, and the taste of the litchi wine is unique; and litchi shells and litchi kernels are utilized, waste is reduced, the litchi shells and the litchi kernels are sprayed with saline water and is parched, a herb guiding effect is achieved, and a curative effect is improved; the litchi wine is adsorbed by the macroporous resin before and after fermentation, brown stain of the litchi wine can be delayed effectively, sensory quality is not affected, and nitrogen is fed into the litchi wine; and the added traditional Chinese medicines have effects of nourishing yin to lessen fire, moisturizing pathogenic dryness to loosen the bowel, securing essence and reducing urination, and relieving diarrhea with astringents.