Method of manufacturing 1-(2-methoxyphenyl)-3-naphthyl group-2-urea

Abstract

A preparation method of the bacterial drug-resistant inhibitor is provided, which is that the Beta-naphthamine is utilized as raw material and reacts with the urea to gain the N-(2-naphthol)- thiourea, and then reacts with the o-amino pheylmethyl ether to gain INF271, namely, 1-(2- methoxyphenyl)-3-naphthyl-2-thiourea. (1) The Beta-naphthamine and urea are added in water and are added with the diluted acid for 1h to 5h heating and reflux and are filtered after cooling to gain 1-(naphthol-2base)-thiourea; (2) 1-(naphthol-2base)-thiourea and the o-amino pheylmethyl ether mix with the diluted acid and are heated to 100 DEG C. to 108 DEG C., and then react for 1h to 5h to gain the 1-(2- methoxyphenyl)-3-naphthyl-2-thiourea after cooling and filtering. The diluted acid applied in the reaction can be sulphuric acid, hydrochloric acid and acetic acid, etc. the priority is hydrochloric acid.

Description

Technical field: [0001] The invention belongs to the preparation technology of veterinary medicine, in particular to a preparation method of 1-(2-methoxyphenyl)-3-naphthyl-2-urea. Background technique: [0002] Due to the continuous and extensive application or even abuse of antibacterial drugs in animal breeding practice, coupled with the objective existence of cross-resistance of antibacterial drugs shared by humans and animals, the drug resistance of pathogenic bacteria is increasing day by day, and the efficacy of many drugs is rapidly declining. Under stress, bacteria develop resistance to almost all clinically used antimicrobials. According to the results of the general survey of bacterial drug resistance by relevant institutions, the drug resistance of Staphylococcus aureus to erythromycin, chloramphenicol, and tetracycline is as high as 80%, 70%, and 60%, respectively, and Escherichia coli is resistant to gentamicin, sulfa , erythromycin resistance as high as 70%, 6...

AI Technical Summary

Problems solved by technology

[0003] In order to solve the problem that the drug resistance of existing pathogenic bacteria is increasing day by day, the purpose of the present invention is to provide a preparation method of bacterial resistance inhibitor INF271, so that the antibacterial and synergistic effect of the new bacterial resistance inhibitor is better, so that animals Major bacterial infections and diseases can be better and effectively controlled, reducing drug costs and improving the safety of animal-derived foods

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