Water gelling agent used for forming supermolecule hydrogel and preparation method thereof

A technology of supramolecular hydrogels and gelling agents, which can be used in toiletry preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of inability to gel the buffer solution, and achieve the effect of great application prospects

Inactive Publication Date: 2008-02-13
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The object of the present invention is to overcome the shortcoming that the aqueous gelling agent of prior art can not make the buffer solution gelation of different pH value, provide a kind of aqueous gelling agent that can make the buffering solution of different pH value form supramolecular hydrogel and its preparation method

Method used

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  • Water gelling agent used for forming supermolecule hydrogel and preparation method thereof
  • Water gelling agent used for forming supermolecule hydrogel and preparation method thereof
  • Water gelling agent used for forming supermolecule hydrogel and preparation method thereof

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example 1

[0024] 1. Under the protection of nitrogen, dissolve L-phenylalanine and bis(trichloromethyl)carbonate with a molar ratio of 1:1.7 in dry tetrahydrofuran solution, and react at 48°C for 4h; cool the reaction mixture to room temperature, remove the tetrahydrofuran solvent under reduced pressure, add 5 times the solution volume of n-hexane to it, and place it overnight at -5°C, the product is filtered to obtain white crystals; use a mixture of ethyl acetate / tetrahydrofuran with a mass ratio of 1:3 It is recrystallized from a solvent, and then dried in vacuum, and the product is abbreviated as L-Phe-NC;

[0025] 2. React L-Phe-NCA with a molar ratio of 1:1 and octadecylamine or hexadecylamine in chloroform at 0°C for 1h, then raise the temperature to 45°C for 3h, precipitate through ether, filter, and dry to obtain The product is abbreviated as C18Phe or C16Phe;

[0026]3. React C18Phe or C16Phe, triethylamine, 6-bromohexanoic acid (3-bromopropionic acid) and thionyl chloride wi...

example 2

[0029] 1. Under the protection of nitrogen, dissolve L-phenylalanine and bis(trichloromethyl)carbonate with a molar ratio of 1:1.7 in dry tetrahydrofuran solution, and react at 51°C for 5h; cool the reaction mixture to room temperature, remove the tetrahydrofuran solvent under reduced pressure, add 5 times the solution volume of n-hexane to it, and place it overnight at -5°C, the product is filtered to obtain white crystals; use a mixture of ethyl acetate / tetrahydrofuran with a mass ratio of 1:3 Solvent is used to recrystallize it, and then vacuum-dried, and the product is abbreviated as L-Phe-NCA;

[0030] 2. React L-Phe-NCA with a molar ratio of 1:1 and octadecylamine or hexadecylamine in chloroform at 0°C for 1h, then raise the temperature to 55°C for 4h, precipitate through ether, filter, and dry to obtain The product is abbreviated as C18Phe or C16Phe;

[0031] 3. React C18Phe or C16Phe, triethylamine, 6-bromohexanoic acid (3-bromopropionic acid) and thionyl chloride wit...

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Abstract

The invention is an aqueous gel and the preparation method; the aqueous gel can make the buffer solution of different pH values form the supramolecular hydrogel. The gel of the invention is the compound N-6-bromide caproyl-L-phenyl amide 18-alkoxy pyridinium salt. The preparation method uses the L-phenylalanine as the starting material. Induce the long-chain alkyl in the molecular structure first and then form the salt. The gel of the invention still has the hand structure and can stably exist in the buffer solution; therefore, the hydrogel has the great prospects in the fields of the biomedical materials and cosmetics.

Description

technical field [0001] The invention relates to a water-based gel and a preparation method thereof, in particular to a water-based gel capable of forming a supramolecular hydrogel from buffer solutions with different pH values ​​and a preparation method thereof. Background technique [0002] In recent years, supramolecular organogels (Supramolecular organogels) formed by small molecule organogels (gelators) in organic solvents have received extensive attention. Supramolecular gel is the research result of supramolecular chemistry. Its formation mechanism is that the small molecule organic gel is dissolved in water and organic solvents by heating, and then cooled to room temperature, through the intermolecular hydrogen bond of the gel, Non-covalent bond interactions such as π-π bonds and van der Waals forces spontaneously aggregate and assemble into an ordered fibrous supramolecular structure. These fiber bundles can further form an entangled three-dimensional network structu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D213/04A61K8/49
Inventor 杨亚江付新建王宁霞
Owner HUAZHONG UNIV OF SCI & TECH
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