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Three-dimension porous tissue engineering carrier material and preparation and application

A three-dimensional porous and tissue engineering technology, applied in prosthetics, medical science, etc., can solve problems such as no similar or similar patents

Inactive Publication Date: 2008-03-26
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Apparently, at present, there are no similar or similar patents or literature reports on the method of preparing tissue engineering carrier materials by fiber fusion method using PHBV / PCL as biomaterials at present.

Method used

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  • Three-dimension porous tissue engineering carrier material and preparation and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The high polymer PCL with a molecular weight of 100,000 and a melting point of 60°C, and the high polymer PHBV with a molecular weight of 460,000 and a melting point of 174°C were melt-spun at 175°C to obtain fibers with an average diameter of 500 μm, which were cut into After the equal length is 10.0mm, fill it into a mold with a specific shape. The filling quality is calculated based on the porosity of 85%. After demoulding, the tissue engineering carrier material with specific shape and good performance can be obtained. The material has a pore diameter of 50-200 μm measured by a scanning electron microscope, a porosity of 82% measured by a liquid displacement method, and a degree of pore penetration of more than 90%. The in vitro degradation cycle is appropriate and the mechanical properties are excellent. The material can be used as a bone tissue engineering carrier material for repairing and reconstructing bone damage.

Embodiment 2

[0021] Polymer PCL with a molecular weight of 80,000 and a melting point of 58-60°C, and a polymer PHBV with a molecular weight of 460,000 and a melting point of 174°C were melt-spun at 175°C to obtain fibers with an average diameter of 500 μm, and cut After the equal length is 10.0mm, fill it into a mold with a specific shape. The filling quality is calculated based on the porosity of 85%. Set the temperature of the vacuum oven at 75°C. After the mold is sealed, place it in the vacuum oven to keep the temperature for 1 hour, take it out, and cool it at room temperature After demoulding, the tissue engineering carrier material with specific shape and good performance can be obtained. The material has a pore diameter of 50-200 μm measured by a scanning electron microscope, a porosity of 84% measured by a liquid displacement method, and a degree of pore penetration of more than 90%. The in vitro degradation cycle is appropriate and the mechanical properties are excellent. The ma...

Embodiment 3

[0023] Polymer PCL with a molecular weight of 50,000 and a melting point of 58-60°C, and a polymer PHBV with a molecular weight of 460,000 and a melting point of 174°C were melt-spun at 175°C to obtain fibers with an average diameter of 500 μm, and cut After the equal length is 6.0mm, fill it into a mold with a specific shape. The filling quality is calculated based on the porosity of 85%. Set the temperature of the vacuum oven at 75.0°C. After the mold is sealed, place it in the vacuum oven to keep the temperature for 1 hour, take it out, and cool it at room temperature After demoulding, the tissue engineering carrier material with specific shape and good performance can be obtained. The pore diameter of the material measured by a scanning electron microscope is 300-500 μm, the porosity measured by a liquid displacement method is 75%, the in vitro degradation period is appropriate, and the mechanical properties are excellent. The material can be used as a bone tissue engineer...

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Abstract

The present invention relates to a three-dimensional porous tissue engineering carrier material, its preparation and application. Said three-dimensional porous tissue engineering carrier material includes three-dimensional porous structure, its internal porous structure is uniform, three-dimensional through degree is above 90%, pore size is 50-500 micrometer and porosity is 65-90%. Its preparation method includes the following steps: using polyhydroxybutyrate valerate (PHBV) and polycaprolactone (PCL) as raw material, mixing them, melting and spinning to obtain fibre whose diameter is 10-500 micrometer, cutting said fibre to make said fibres have identical length, making said fibres be uniformly arranged and filled into a mould, sealing said mould for 5min-1n at 50-80deg.C, demoulding, sterilizing and packaging so as to obtain the invented product. Said product can be used for repairing or reconstructing some tissue organs.

Description

technical field [0001] The invention belongs to the field of biological tissue engineering carrier material and its preparation and application, in particular to a three-dimensional porous tissue engineering carrier material and its preparation and application. Background technique [0002] The loss or dysfunction of tissues and organs is one of the major hazards to human health and one of the leading causes of human disease and death. Although traditional autologous transplantation, allograft and artificial substitutes have shown good therapeutic effects, their application is limited by the defects of immune rejection, limited source of donors or need for secondary surgery. In recent years, an ideal strategy is to artificially cultivate tissues and organs, and then the concept of "tissue engineering" was put forward, and its basic method was proposed in Langer R, Vacanti J P.Tissue Engineering.Science, 1993, 260(5110): 920 of: The high-concentration tissue cells cultured i...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/26
Inventor 杨庆王细建郯志清沈新元彭兰兰陈思诗
Owner DONGHUA UNIV
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