Pharmaceutical composition of snakegourd fruit and whitethorn leaf

A technology of hawthorn leaf extract and composition, applied in the field of medicine, to achieve the effects of anti-platelet aggregation, reducing the size of myocardial infarction, and reducing the left ventricular end-diastolic pressure

Inactive Publication Date: 2008-04-02
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, using the interaction between Trichosanthes or Trichosanthes extract and Hawthorn leaf or Hawthorn leaf extract to prepare prescriptions for treating cardiovascular and cerebrovascular diseases has not been reported yet.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0158] Example 1 Preparation of Hawthorn Leaf Extract

[0159] 1, the preparation method of hawthorn leaf extract

[0160] Take hawthorn leaves, dry and crush them, add 60% ethanol to reflux and extract three times, each time for 1 hour, add 8 times the amount of ethanol, combine the extracts, filter, and recover the ethanol from the filtrate under reduced pressure until the relative density is 1.04-1.06 (60°C) After diluting with an equal amount of water, shake and extract with 1 / 2 times the amount of petroleum ether (60-90°C), discard the petroleum ether solution, shake and extract the aqueous layer with ethyl acetate, and depressurize the extract Recover ethyl acetate and concentrate to dryness, then add appropriate amount of water to dissolve, add to the treated polyamide column (30-60 mesh, wet packing with ethanol, pre-wash with appropriate amount of ethanol, then wash with water until no alcohol smell, set aside ), first eluted with 2 times column volume of water, di...

Embodiment 2

[0176] Example 2 Preparation of Trichosanthes Fructus Extract

[0177] 1, the preparation method of Trichosanthes quince extract

[0178] Take Trichosanthes medicinal material, dry, make coarse powder, add water and reflux to extract twice, each time 10 times the amount, 2 hours each, combine the extracts, filter, concentrate the filtrate to a relative density of 1.10-1.15 (60°C), add ethanol When the alcohol content reaches 80%, leave it overnight, take the supernatant, recover ethanol to a concentrated solution with a relative density of 1.04-1.06 (60°C), add an equal amount of water to dilute, then shake and extract twice with an equal amount of petroleum ether , the water liquid was shaken and extracted 3 times with an equal amount of water-saturated n-butanol, combined the n-butanol extracts, concentrated to dryness, added a small amount of water to dissolve the residue, put it on a macroporous resin column, and washed it with 1 times the column volume of water Remove,...

Embodiment 3

[0188] Example 3 Preparation of GS Composition Aqueous Injection

[0189] Prescription one:

[0190] Hawthorn leaves 2000g

[0191] Trichosanthes 5000g

[0192] Macrogol 400 200ml

[0193] Ethanol 200ml

[0194] Add water for injection to 2000ml

[0195]

[0196] A total of 1000 sticks were prepared

[0197] Preparation Process:

[0198] The hawthorn leaves and trichosanthes in the raw materials were prepared as extracts according to the preparation methods in Examples 1 and 2.

[0199] (1) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them with fresh water for injection before use.

[0200] (2) Mix ethanol with an equal amount of water, add hawthorn leaf extract and Trichosanthes extract to dissolve; dissolve polyethylene glycol 400 with 50% water.

[0201] (3) Combine the above two solutions, and add water for injection to the full amount.

[0202] (4) Add activated carbon for n...

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PUM

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Abstract

The invention belongs to the medical technical field and discloses a drug combination used for the cardio-cerebrovascular disease. The drug combination contains the pharmacodynamic components of the raw materials of the drugs of snakegourd or snakegourd extract and hawthorn leaves or hawthorn leaf extract. The invention also discloses preparations, which contain the drug combination and the preparation method of the preparations. The drug combination can be made into the preparation type, which is acceptable in the clinic or the pharmacy, and the injection preparation and the oral preparation are preferential. The drug combination is mainly used for remedying the cardio-cerebrovascular diseases of the coronary heart disease, the angina, the miocardial infarction, the blood stasis type corpulmonale, the ischemic encephalopathy, the cerebral thrombosis, the hypertension, the hyperlipemia etc. The drug combination of the invention has the synergistic interaction. Compared with simply using the snakegourd or the snakegourd extract and the hawthorn leaves or the hawthorn leaf extract, the effect is improved greatly, and the invention is provided with low toxicity, high safety and good stability.

Description

[technical field] [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition for cardiovascular and cerebrovascular diseases. The raw material medicine consists of trichosanthes or its extract and hawthorn leaf or its extract, and provides a preparation method and preparation thereof. [Background technique] [0002] Cardiovascular and cerebrovascular diseases include coronary heart disease, angina pectoris, myocardial infarction, congestive pulmonary heart disease, ischemic encephalopathy, cerebral thrombosis, hypertension, hyperlipidemia, etc. The main cause of these diseases is that arteriosclerosis causes narrowing of the lumen and blockage of the pipeline, which leads to insufficient blood supply to the heart and brain, causing symptoms such as dizziness, dizziness, headache, and chest tightness. In severe cases, it can lead to stroke and myocardial infarction. Cardiocerebral ischemia affects energy metabolism, secondary ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/734A61P9/10A61P9/12A61P3/06A61P7/02
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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