Pharmaceutical composition of snakegourd fruit and whitethorn leaf
A technology of hawthorn leaf extract and composition, applied in the field of medicine, to achieve the effects of anti-platelet aggregation, reducing the size of myocardial infarction, and reducing the left ventricular end-diastolic pressure
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Embodiment 1
[0158] Example 1 Preparation of Hawthorn Leaf Extract
[0159] 1, the preparation method of hawthorn leaf extract
[0160] Take hawthorn leaves, dry and crush them, add 60% ethanol to reflux and extract three times, each time for 1 hour, add 8 times the amount of ethanol, combine the extracts, filter, and recover the ethanol from the filtrate under reduced pressure until the relative density is 1.04-1.06 (60°C) After diluting with an equal amount of water, shake and extract with 1 / 2 times the amount of petroleum ether (60-90°C), discard the petroleum ether solution, shake and extract the aqueous layer with ethyl acetate, and depressurize the extract Recover ethyl acetate and concentrate to dryness, then add appropriate amount of water to dissolve, add to the treated polyamide column (30-60 mesh, wet packing with ethanol, pre-wash with appropriate amount of ethanol, then wash with water until no alcohol smell, set aside ), first eluted with 2 times column volume of water, di...
Embodiment 2
[0176] Example 2 Preparation of Trichosanthes Fructus Extract
[0177] 1, the preparation method of Trichosanthes quince extract
[0178] Take Trichosanthes medicinal material, dry, make coarse powder, add water and reflux to extract twice, each time 10 times the amount, 2 hours each, combine the extracts, filter, concentrate the filtrate to a relative density of 1.10-1.15 (60°C), add ethanol When the alcohol content reaches 80%, leave it overnight, take the supernatant, recover ethanol to a concentrated solution with a relative density of 1.04-1.06 (60°C), add an equal amount of water to dilute, then shake and extract twice with an equal amount of petroleum ether , the water liquid was shaken and extracted 3 times with an equal amount of water-saturated n-butanol, combined the n-butanol extracts, concentrated to dryness, added a small amount of water to dissolve the residue, put it on a macroporous resin column, and washed it with 1 times the column volume of water Remove,...
Embodiment 3
[0188] Example 3 Preparation of GS Composition Aqueous Injection
[0189] Prescription one:
[0190] Hawthorn leaves 2000g
[0191] Trichosanthes 5000g
[0192] Macrogol 400 200ml
[0193] Ethanol 200ml
[0194] Add water for injection to 2000ml
[0195]
[0196] A total of 1000 sticks were prepared
[0197] Preparation Process:
[0198] The hawthorn leaves and trichosanthes in the raw materials were prepared as extracts according to the preparation methods in Examples 1 and 2.
[0199] (1) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them with fresh water for injection before use.
[0200] (2) Mix ethanol with an equal amount of water, add hawthorn leaf extract and Trichosanthes extract to dissolve; dissolve polyethylene glycol 400 with 50% water.
[0201] (3) Combine the above two solutions, and add water for injection to the full amount.
[0202] (4) Add activated carbon for n...
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