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Method for producing traditional Chinese medicine preparation of six ingredients with rehmannia

A technology of Liuwei Dihuang and its production method, which is applied in the fields of medical formulation, drug delivery, drug combination, etc., can solve problems such as poor removal of drug impurities and ineffective ingredients, insufficient stability of drug quality, and increased patient dosage, etc., to achieve The effect of maintaining stable drug quality, reducing the dosage, and avoiding the loss of polysaccharide components

Inactive Publication Date: 2008-04-30
HUNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The combination of the three medicines can nourish the liver, spleen, and kidneys, but it is mainly for nourishing the kidney yin, which is not enough to cure the root cause
[0003] However, through the observation of the actual production process of the existing Liuwei Dihuang preparation and its drug use, it is found that there are certain problems, mainly: the impurities and ineffective ingredients in the drug are not well removed, the quality stability of the drug is not enough, and the quality control more difficult
Due to the existence of some macromolecular ineffective components such as starch, phlegm, and protein in the water extract of traditional Chinese medicine, it will not only increase the amount of the drug taken by the patient, but also increase the load on the liver, kidney, spleen, etc.

Method used

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Experimental program
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Effect test

Embodiment Construction

[0026] a. Get 528 grams of Cortex Moutan, add 10 to 5 times the amount (parts by weight) of water, carry out steam distillation, and filter the distillate to obtain the crude product, dissolve the crude product with 95% to 99% ethanol, reclaim the ethanol, and obtain Paeonol crystals, paeonol crystals and dregs for subsequent use;

[0027] b. Take 704 grams of Cornus officinalis and 528 grams of Alisma, add ethanol solution to reflux extraction, filter, and use the dregs for later use, recover ethanol from the filtrate, and concentrate to a thick paste;

[0028] c. Take the above Moutan bark, Cornus officinalis, Alisma dregs, 1408 grams of Rehmannia glutinosa, 704 grams of Chinese yam, and 528 grams of Poria cocos, add 5-15 times the weight of these materials and decoct three times, each time for 0.8 hours to 1.2 hours, filter Pass and combine the filtrate, take the filtrate and centrifuge at a high speed, the centrifuge speed is 15000~30000rpm;

[0029] d. Pass the liquid af...

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Abstract

The invention relates to a process for preparing the medicament of a six-drug including rehmannia of the traditional Chinese medicine. According to the standard of the Chinese pharmacopeia, volatile oil in bark of peony root is distilled and extracted by aqueous vapor, an alcohol-soluble ingredient in dogwood and rhizoma alismatis is extracted by ethanol solution. After the mixing and the decoction of the residual decoction dregs and the left three drugs, the method of the high-speed centrifugation is adopted for removing the suspending granules and a plurality of the macromolecular impurities in the solution, then using the method of the uniting of the macroreticular resin and the hyperfiltration, the solution is filtrated and separated, and further the medicament of the six-drug including rehmannia of the traditional Chinese medicine is achieved. The invention has the advantages of simple post-treatment and less spillage of the active ingredient without any pollution, and the achieving rate of the active ingredient is increased. Due to the affinage of the active ingredient of the achieved medicament, the dosage of the patient is reduced, and the curative effect keeps stable.

Description

technical field [0001] The invention relates to a production process of a Chinese patent medicine, and further refers to a production method of Liuwei Dihuang preparation. Background technique [0002] Traditional Chinese medicine is a treasure of the Chinese nation with a long history of more than 5,000 years. Liuwei Dihuang Wan is a well-known formula in Chinese patent medicine, which embodies the essence of syndrome differentiation and prescription in traditional Chinese medicine. Liuwei Dihuang Wan is derived from the Shenqi Wan in "Synopsis of the Golden Chamber". The ancients subtracted the cinnamon twigs and aconite from the original prescription to become the traditional Liuwei Dihuang Wan. The traditional prescription consists of 24g Rehmannia glutinosa, 12g Cornus officinalis, 12g dried yam, 9g Alisma, 9g Poria cocos (peeled) and 9g paeonol. Its main function is to nourish the liver and kidney. Chinese medicine believes that the kidney is the innate foundation, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/00A61P1/14A61P13/12
Inventor 徐伟箭刘含茂熊远钦曾松军
Owner HUNAN UNIV