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Polygonin sheet dose and preparing method thereof

A polydatin tablet and a technology of polydatin, which is applied in the direction of anti-toxins, pill delivery, and pharmaceutical formulations, can solve problems such as difficult to meet the high-dose dissolution effect of drugs, and achieve environmental protection and large-scale industrial production and reduce dosage , good fluidity and compressibility

Active Publication Date: 2008-06-18
SHENZHEN NEPTUNUS PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above research facts show that it is difficult to meet the requirements of ensuring a high dose of the drug while achieving a better dissolution effect by using solid preparation excipients or preparation processes well-known in the art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] [Example 1] Using different adhesives to prepare polydatin tablets

[0018] Prescription: Polydatin 400mg

[0019] Microcrystalline cellulose 22mg

[0020] Lactose 64mg

[0021] Crospovidone 10mg

[0022] Magnesium stearate 4mg

[0023]

[0024] Total 500mg

[0025] Choose 3% povidone K-25, K-30, K-60 50% ethanol solution, 3% hydroxypropyl methyl cellulose (HPMC) aqueous solution, 10% starch slurry as the binder.

[0026] Preparation method: Weigh polydatin, filler and disintegrant according to 50 times the prescription amount, pass through 60 mesh sieve, 80 mesh sieve, mix uniformly, use the above-mentioned binder to make soft material, granulate with 30 mesh sieve, and dry at 60°C. The water content of the granules is controlled within 3%. After the granules are sized by a 20-mesh sieve, an appropriate amount of lubricant is added, mixed evenly, and compressed to obtain the product.

[0027] Testing indicators and methods:

[0028] Dis...

Embodiment 2

[0034] [Example 2] Preparation of polydatin tablets:

[0035] The preparation method of the tablet is as follows:

[0036] Weigh out the polyvinyl cuspidatum, the filler and the disintegrant according to 50 times the prescription amount, pass through 60 mesh sieve, 80 mesh sieve, mix well, use 2.0~3.5% povidone K30 in 50% ethanol solution to make soft material, 30 mesh sieve granulate , Dry at 60°C, control the moisture content of the particles within 3%, add appropriate amount of lubricant after sizing through a 20-mesh sieve, mix evenly, and press tablets to obtain the product.

experiment example 1

[0037] Experimental example 1 Polygonaside tablets (specification 200mg / tablet) prescription:

[0038] Polydatin 200mg

[0039] Microcrystalline cellulose 40mg

[0040] Lactose 58mg

[0041] Magnesium stearate 2mg

[0042]

[0043] Total 300mg

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PUM

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Abstract

The invention provides a polydatin tablet and a preparation method of the polydatin tablet. According to the weight ratio, the polydatin tablet contains 50 to 90 percent of active component, 0 to 2.5 percent of disintegrant, 0.2 to 1.0 percent of lubricant and the rest is filler. The preparation method is as flowing: the proportional polydatin, the filler and the disintegrant are made to pass through the screen of 60 to 100 orders; the screened polydatin, the filler and the disintegrant are well mixed; the mixture is made into soft material with 1.5 to 4.5 percent of povidone solution; grains are made by the screen of 20 to 50 orders; the grains are dried in the temperatures of 40 to 90 DEG C; the water in the grains is controlled within 3 percent; after the grains are finished, the proper lubricant is added into the grains; the lubricant and the grains are well mixed; the grains are filled into the capsules or the squash; and then the finished product is obtained. The highest content of the main drugs in the polydatin tablet can reach 90 percent; the tablet can disintegrate in short time; at the same time, all the dissolution rates of the drugs reach above 85 percent; and the preparation process of the invention is simple. Thus, the invention is suitable for industrialized mass production.

Description

Technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to a polydatin tablet and a preparation method thereof. Background technique [0002] Polydatin (Polydatin, PD) is the fourth monomer extracted from the dried rhizomes of Polygonum Cuspidatum Sieb.et Zucc (Polygonum Cuspidatum Sieb.et Zucc), so it is also known as Polygonum Cuspidatum No. 4; it can also be called resveratrol. Glycosides. PD is widely distributed in plants, high in content, and has strong biological activity. Modern pharmacological studies have shown that PD has significant effects on cardiomyocytes, vascular smooth muscle cells, anti-platelet aggregation, and improving microcirculation. In addition, it can reduce tissue and organ damage caused by various factors, protect liver cells, resist oxidation, and lower blood lipids. And anti-lipid peroxidation. [0003] Polydatin has extremely low solubility, and its saturated concentration in wate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7032A61K9/20A61K47/34A61K47/38A61P1/16A61P3/06A61P7/02A61P39/06A61K47/32
Inventor 周玉平康晖李勇叶勤赵金华冯汉林
Owner SHENZHEN NEPTUNUS PHARM CO LTD