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Method for synthesizing guanine from urea

A technology of guanine and urea, applied in the field of chemical industry, achieves the effect of low price and low consumption of raw materials

Active Publication Date: 2008-07-09
江苏八巨药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a kind of technique of synthetic guanine with urea for the shortcoming of existing guanine synthetic method

Method used

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  • Method for synthesizing guanine from urea

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Add 15 grams of urea to the dried 500 milliliter three-necked bottle, and then add 75 milliliters of formic acid (94% by weight, about 90 grams), and stir at room temperature to make the solution completely clear.

[0022] Continue to add 48 grams of 2,4,5-triamino-6-hydroxypyrimidine sulfate (industrial grade, content 95%) into the three-necked bottle. After casting, heat up to reflux. Add 50 grams of formic acid (content 94%) in the there-necked flask with a constant pressure titration funnel at a faster speed through a spherical condenser, and drop it in about 5 minutes; continue to reflux.

[0023] Reflux and keep warm for 15 hours, first evaporate part of the formic acid at normal pressure, and then evaporate the formic acid to dryness under a negative pressure less than 0.1Mpa.

[0024] Dissolve the solid obtained in the three-necked bottle with an appropriate amount of hydrochloric acid solution, decolorize, and adjust the mother liquor to neutrality with lye to...

Embodiment 2

[0028] Utilize the formic acid that content is 86%, other is with embodiment 1, and the results are shown in Table 1.

Embodiment 3

[0032] Utilize the formic acid that content is 79.5%, other is with embodiment 1, and the results are shown in Table 1.

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Abstract

The invention discloses a process for synthesizing guanine with urea, which comprises firstly reacting urea with formic acid, adding 2, 4, 5- triamino-6-hydroxy pyrimidine sulphate and further adding formic acid to react continuously, finally obtaining guanine. The invention has the advantages of simple operation, low device demand and stable product yield, less raw material consumption, low cost and raw material cost, high product yield and excellent product quality, which does not generate inorganic salt in the reaction process, and is easy to be refined.

Description

technical field [0001] The invention belongs to the field of chemical industry, and in particular relates to a method for synthesizing guanine with urea. Background technique [0002] At present, in China, there are mainly three mature synthesis processes for guanine: 1. formamide process; 2. formylation process; 3. sodium formate process. [0003] Formamide process: heat 2,4,5-triamino-6-hydroxypyrimidine sulfate (commonly known as triamine, hereinafter referred to as TAHP) in formamide (hence the name of the process) to 200°C and keep it warm for about 6 hours. Synthesis of crude guanine. refined. The advantages and disadvantages of this process are obvious: the reaction time is short, the operation is convenient; and inorganic salts will not be produced; It is difficult to refine the crude colored guanine; in addition, it requires high equipment. [0004] Formylation process: first make a weak base solution with an appropriate amount of ammonia water (or liquid ammoni...

Claims

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Application Information

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IPC IPC(8): C07D473/18
Inventor 邱颢孔立陈恬
Owner 江苏八巨药业有限公司
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