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Anetholtnithoines and preparing method thereof

A technology of anisitrazine and secondary granulation, applied in the field of chemical medicine, can solve the problems of inability to satisfy patients, low dissolution rate and bioavailability, slow onset of drug effect, etc., and achieves fast onset of effect, high bioavailability and broad The effect of the application foreground

Active Publication Date: 2010-06-16
CHENGDU AUPONE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its dissolution rate and bioavailability are low, and the drug has a slow onset of action, which cannot meet the needs of patients

Method used

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  • Anetholtnithoines and preparing method thereof
  • Anetholtnithoines and preparing method thereof
  • Anetholtnithoines and preparing method thereof

Examples

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preparation example Construction

[0031] The preparation process of fennel three stream tablet of the present invention

[0032] 1. Mixing, crushing, sieving

[0033] Put anetellitate, lactose and carboxymethyl starch sodium into a wet mixing granulator and mix for 2 minutes. The uniformly mixed medicinal powder is pulverized with a pulverizer, and the pulverizer is installed (80-100 mesh sieve), and pulverized twice.

[0034] 2. One-time granulation

[0035] Put the mixed medicine powder and pregelatinized starch into the wet mixing granulator according to 25.0-45.0kg per pot and pre-mix for 30 seconds. Divide the povidone K30 solution with a concentration of 6% according to the number of pots, and divide each pot three times Add it to make a soft material, stir and chop for 30 seconds for the first and second times, and stir and chop for 180 seconds after the third addition. Then granulate with a 14-mesh nylon screen on a swing granulator. Spread the prepared wet granules on a stainless steel plate with ...

Embodiment 1

[0046] Example 1 Preparation of Anetellithin Tablets with a specification of 12.5 mg in the present invention

[0047] A standard batch of 360,000 tablets was prepared, and each tablet was in the dosage form of 12.5 mg.

[0048] Prescription (unit: kg):

[0049] Anetellithin (as C 10 h 8 OS 3 count) 4.5

[0050] Lactose 45

[0051] Sodium carboxymethyl starch 3.6

[0052] Pregelatinized starch 27

[0053] Povidone K30 1.50

[0054] Magnesium stearate 0.43

[0055] Coating premix excipients 2.52

[0056] After mixing and pulverizing the prescribed amount of anetis, lactose, and sodium carboxymethyl starch, adding pregelatinized starch and mixing, adding 6% povidone K30 aqueous solution to make soft material granulation, drying, Grinding, adding purified water for secondary granulation, drying and sizing, then mixing magnesium stearate, compressing into tablets, and coating.

Embodiment 2

[0057] Example 2 Preparation of Anetellithin Tablets with a specification of 25 mg in the present invention

[0058] A standard batch of 360,000 tablets was prepared, and each tablet was in the dosage form of 25 mg.

[0059]Prescription (unit: kg):

[0060] Anetellithin (as C 10 h 8 OS 3 Count) 9

[0061] Lactose 45

[0062] Sodium carboxymethyl starch 3.6

[0063] Pregelatinized starch 27

[0064] Povidone K30 1.50

[0065] Magnesium stearate 0.43

[0066] Coating premix excipients 2.52

[0067] After mixing and pulverizing the prescribed amount of anetis, lactose, and sodium carboxymethyl starch, adding pregelatinized starch and mixing, adding 6% povidone K30 aqueous solution to make soft material granulation, drying, Grinding, adding purified water for secondary granulation, drying and sizing, then mixing magnesium stearate, compressing into tablets, and coating.

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Abstract

The invention relates to anethol trithione tablets and a preparation method thereof, pertains to the chemical drug technical field and solves the technical problems of the low dissolution and bioavailability of the anethol trithione tablet. The anethol trithione tablet of the invention is prepared by two pelletizing processes and the active ingredient thereof is anethol trithione (5-(4-Methoxyphenyl)-1, 2-dithio-3-thione). The dissolution of the anethol trithione tablet of the invention is over 15 percent higher than that of the anethol trithione tablet prepared by the existing one-time pelletizing method and the invention has higher bioavailability and shorter onset time, meets the demand of patients and has wide application prospect.

Description

technical field [0001] The invention relates to anetellithin tablets and a preparation method thereof, belonging to the technical field of chemical medicines. technical background [0002] Anethole trithione, also known as bilivitamin and anethole trithione, its chemical name is: 5-p-methoxyphenyl-3H-1,2 dithio-3-thione, molecular formula: C 10 h 8 OS 3 , molecular weight: 240.35. The compound can significantly enhance the vitality of liver cells, increase the secretion of bile, bile acid and bile pigment, belongs to the secretory choleretic drug, and can enhance the detoxification function of the liver. Clinically, it is mainly used to treat cholecystitis, cholangitis, cholelithiasis, acute and chronic hepatitis, cirrhosis, fatty liver, etc. It can also be used for dry mouth caused by radiotherapy and chemotherapy, and it also has the effect of sobering up and hangover. [0003] At present, there are many dosage forms of anethridine in the market, and the most widely us...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/30A61K31/385A61P1/16
Inventor 刘波魏岚朱钰
Owner CHENGDU AUPONE PHARMA CO LTD