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Application of acetophenetidin in preparation of medicaments for testing liver cancer high risk group

A technology for phenacetin and liver cancer, a new use of phenacetin, and the application field of phenacetin in the preparation of drugs for detecting high-risk groups of liver cancer

Inactive Publication Date: 2008-07-23
李晓冬 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there is no drug available to detect high-risk groups for liver cancer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: the preparation of phenacetin capsule

[0017] According to the relevant provisions of "Pharmacopoeia of the People's Republic of China" 2005 edition capsules, phenacetin (medicinal raw materials provided by Jiamusi Luling Pharmaceutical Co., Ltd.) is prepared into capsules for men (0.25 g / grain) and capsules for women (0.2125 g / capsule) Two specifications, 4 capsules per plate, packed in aluminum foil.

Embodiment 2

[0018] Embodiment 2: the preparation of phenacetin injection

[0019] According to the relevant regulations of "Pharmacopoeia of the People's Republic of China" 2005 edition injection, phenacetin (medicinal raw material is provided by Jiamusi Luling Pharmaceutical Co., Ltd.) is prepared into a 0.15% injection, and its solvent is ethanol: water for injection=15:85 (v / v), in aliquots of 2 ml medicinal glass vials. After sealing, autoclave.

Embodiment 3

[0020] Example 3: Research on phenacetin as a diagnostic drug for detecting high-risk groups of liver cancer

[0021] Objective: To study whether phenacetin, as a diagnostic drug, can be used to detect high-risk groups of liver cancer.

[0022] Instrument: 20A high performance liquid chromatography (manufactured by Shimadzu Corporation, Japan, including LC-20AD pump, DGU-20A online degasser, SIL-HTC autosampler, ODS c18 Chromatographic column 4.6×250 mm, mobile phase: acetonitrile-0.1% formic acid (30:70), isocratic elution, flow rate 1 mL / min, injection volume 20 μL).

[0023] Subjects of parallel experimental design: 24 patients with chronic hepatitis B, Child-Pugh grade A. Aged 26-59 years old, including 18 males and 6 females. Eighteen patients with primary hepatocellular carcinoma had a history of chronic hepatitis B, and the Child-Pugh classification was A. Aged 38-62 years old, including 13 males and 5 females. The normal control group consisted of 12 people, half m...

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PUM

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Abstract

The invention relates to a new application of phenacetin, belonging to medical drug technical field, in particular to the application of drug preparation for detecting liver cancer high risk group, while prior art has not drug to detect liver cancer high risk group. The invention provides a phenacetin application in the drug preparation for detecting liver cancer high risk group, while the phenacetin is oral preparation or injection, the liver cancer high risk group is chronic liver patient infected by virus B hepatitis or hepatitis B virus carrier. Tests prove that in the chronic liver disease patient infected by virus B hepatitis or the hepatitis B virus carrier, phenacetin oxygen de-ethyl metabolism has high activity, if the sulfate combination II phase reaction of the metabolite acetaminophen of phenacetin has high activity, the people belongs to liver cancer high risk group, while the chronic liver disease patient without liver cancer high risk has low activity of phenacetin oxygen de-ethyl metabolism.

Description

technical field [0001] The invention relates to the technical field of medical drugs, in particular to a new application of phenacetin, that is, the application of phenacetin in the preparation and detection of drugs for high-risk groups of liver cancer. Background technique [0002] my country is one of the countries with the highest incidence of liver disease in the world, and the carriers of hepatitis B virus alone are as high as more than 100 million people, accounting for more than 10% of the total population of our country. Every year, 1 million newborns may be infected with hepatitis B virus due to vertical transmission from mother to child. Recent epidemiological studies have shown that primary hepatocellular carcinoma is the fifth most common tumor in the world, with approximately 564,000 new cases each year. In my country, there are about 300,000 new patients with primary hepatocellular carcinoma each year, accounting for more than half of the global incidence of ...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N33/48A61B5/00
Inventor 贺平李晓冬
Owner 李晓冬