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Rhizoma anemarrhenae extrac and applications as type 2 diabetes-curing medicine thereof

An Anemarrhena Anemarrhena extract, the technology of extract, applied in the field of diabetes medicine, can solve the problems of lowering blood sugar, lowering insulin resistance, lowering serum insulin level, etc. The effect of medical value and economic benefits

Inactive Publication Date: 2008-07-30
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Mangiferin and mangiferin-7-O-β-glucoside have no effect on blood sugar in normal mice, but they can lower blood sugar in KK-Ay mice and have a tendency to lower serum insulin levels. The hypoglycemic mechanism may be to reduce insulin resistance

Method used

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  • Rhizoma anemarrhenae extrac and applications as type 2 diabetes-curing medicine thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Preparation of Anemarrhena Jiangtang Tablets

[0023] (1) Pulverize the Anemarrhena medicinal material, extract twice with 8 times the volume of 80% ethanol for 1 hour each time, let cool and then filter, combine the filtrates, and concentrate to obtain a thick paste 1.

[0024] (2) Take thick ointment 1, dissolve it with 8 times the volume of water, put it on a macroporous resin column, elute with 5 column volumes of distilled water, and discard the eluent. Elute with 50% ethanol solution for 8 column volumes, concentrate the eluent to no alcohol, let stand, precipitate precipitate, filter, dry and pulverize the precipitate to obtain Extract 1, namely Anemarrhena extract.

[0025] (3) Weigh 250 g of the above Anemarrhena extract, add 250 g of calcium sulfate, and 10 g of crospovidone and mix well. Use an appropriate amount of 80% ethanol as a wetting agent to make a soft material, granulate with a 14-mesh sieve, dry at 60°C and pass through a 12-mesh sieve f...

Embodiment 2

[0026] Example 2 Preparation of Anemarrhena Jiangtang Tablets

[0027] (1) Pulverize the anemarrhena medicinal material, extract twice with 8 times the volume of 80% ethanol, each time for 1 hour, let cool and filter, combine the filtrate, concentrate to obtain a thick paste 1; add 8 times the volume of water to extract the residue after filtration 2 times, 1 each time, filtered while hot, combined the filtrates, and concentrated to obtain a thick paste 2.

[0028] (2) Take thick ointment 1, dissolve it with 8 times the volume of water, put it on a macroporous resin column, elute with 5 column volumes of distilled water, and discard the eluent. 8 column volumes were eluted with 50% ethanol, and the eluate was concentrated to no alcohol, left to stand, precipitated, filtered, dried and pulverized to obtain extract 1.

[0029] (3) Take the thick ointment 2, add 20 times the volume of water to dissolve it, filter it with an ultrafiltration membrane device and an ultrafiltration ...

Embodiment 3

[0032] Example 3 Preparation of Zhimu Jiangtang Capsules

[0033] (1) Pulverize the anemarrhena medicinal material, extract twice with 10 times the volume of 80% ethanol, each time for 1 hour, filter after cooling, combine the filtrate, concentrate to obtain a thick paste 1; add 10 times the volume of water to extract the residue after filtration 2 times, 1 each time, filtered while hot, combined the filtrates, and concentrated to obtain a thick paste 2.

[0034] (2) Take the thick paste 1, dissolve it completely with 8 times the volume of water, and put it on the treated macroporous resin column. Elute with 3 column volumes of distilled water and discard the eluate. The 6 column volumes were eluted with 60% ethanol, and the eluate was concentrated to no alcohol, left to stand, precipitated, filtered, dried and pulverized to obtain extract 1.

[0035] (3) Take the thick ointment 2, add 10 times the volume of water to dissolve it, filter it with an ultrafiltration membrane de...

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Abstract

The invention discloses an anemarrhenae extract and the application as a medicine treating type II diabetes thereof. The invention uses membrane separation technology, macropore to absorb resin separation and refines anemarrhenae extract after extracting the hizome anemarrhenae by water and ethanol with water. The main activities of the anemarrhenae extract of the invention are three kinds or any two kinds among anemarrhenae saponins, anemarrhenae polysaccharides and double benzene pyrrole ketones, and the total content of the main active components is up to more than 50 percent. The pharmacological experiment of the anemarrhenae extract of the invention proves that the medicine has a big medical value and economic benefit as the medicine for treating or preventing type II diabetes and the complications thereof.

Description

technical field [0001] The invention relates to the field of diabetes drugs, in particular to an anemarrhena extract used for treating diabetes. Background technique [0002] Rhizoma Anemarrhenae is the dry rhizome of Liliaceae (Anemarrhena asphodeloides), which is bitter and cold in nature and has the effects of clearing heat and purging fire, promoting body fluid and moistening dryness. It is a commonly used bitter cold and heat-clearing medicine. [0003] Modern studies have shown that timosaponin, chimonin, mangiferin and their glucosides and anemaran contained in Anemarrhena lower blood sugar through different mechanisms and can be used to treat non-insulin-dependent diabetes. [0004] Timosaponin can control blood sugar levels by restoring the function of islet β cells, enhancing the sensitivity of peripheral tissues to insulin, and inhibiting the activity of α-glucosidase. [0005] Anemarrhena polysaccharide can reduce the blood sugar index of normal mice and alloxan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8964A61P3/10
Inventor 冯毅凡孟青郭晓玲石忠峰吴妍
Owner GUANGDONG PHARMA UNIV
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