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Single-component activation pentanedial disinfecting agent and preparation thereof

The technology of a disinfectant and glutaraldehyde, which is applied in the field of activated glutaraldehyde disinfectant and its preparation, can solve the problems of low bactericidal spore killing speed, reduced bactericidal effect, unstable solution, etc., and achieves strong bactericidal effect, The effect of less air pollution and faster speed

Active Publication Date: 2008-08-13
SHANGHAI LIKANG DISINFECTION HIGH TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. Acidic glutaraldehyde, with a pH value of 3.2-4.6, has good stability and can be stored at room temperature for 18 months, but its bactericidal effect and killing speed on bacterial spores are lower than those of neutral and alkaline glutaraldehyde
[0005] 2. Neutral glutaraldehyde, with a pH value of about 7.0, has a faster rate of killing bacterial spores than acid glutaraldehyde, but its stability is poor. If it is placed at room temperature for 3 to 4 weeks, the concentration will decrease significantly, and the bactericidal effect will also decrease. Significantly reduced
[0006] 3. Alkaline glutaraldehyde, the pH value is adjusted to 7.5-8.5. It has the fastest rate of killing bacterial spores, but the solution is unstable. It is placed at room temperature for 2 weeks, and the concentration is obviously reduced, and the bactericidal effect is also significantly reduced.
However, due to the poor stability of neutral or alkaline glutaraldehyde, commercially available neutral or alkaline glutaraldehyde can only be packaged in two-component packages, that is, sodium bicarbonate and glutaraldehyde are packaged separately and mixed before use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Add 5 grams of polyethylene glycol 4000, add 903 grams of water, heat and mix at 60°C for 1 hour, cool to 40°C, add 20 grams of boric acid, 15 grams of borax, and 2 grams of sodium ascorbate, mix for 1 hour, add alkylphenol polyoxygen Mix 10 grams of vinyl ether and 20 grams of sodium polyacrylate for 1 hour, add 25 grams of glutaraldehyde, and mix for 1 hour to obtain a disinfectant with a pH of 7.0.

[0032] This embodiment disinfectant glutaraldehyde content 25000mg / L, effect 3.5hour to the average killing logarithmic value of Bacillus subtilis var. niger spores all more than or equal to 5.00. It acts on the spores of Bacillus subtilis var. niger stained on the tooth marks of tweezers for 3.5 hours, and they grow aseptically after many tests. The minimum qualified concentration of the disinfectant energy test of the present invention is that the glutaraldehyde content is 2000mg / L. After the disinfectant of the present invention was used continuously for 14 days, the...

Embodiment 2

[0034] Add 2 grams of polyvinyl alcohol, add 863 grams of water, heat and mix at 80°C for 2 hours, cool to 50°C, add 40 grams of boric acid, 10 grams of borax, and 5 grams of sodium metabisulfite, mix for 1 hour, add fatty alcohol polyoxyethylene ether 10 gram, 20 grams of sodium polyacrylate, mixed for 1 hour, added 50 grams of glutaraldehyde, and mixed for 1 hour to obtain a disinfectant with a pH of 5.5.

[0035] After this embodiment disinfectant and water are diluted with 1: 1 ratio, glutaraldehyde content is 25000mg / L, and the average killing logarithmic value of effect 3.5hour to Bacillus subtilis var. It acts on the spores of Bacillus subtilis var. niger stained on the tooth marks of tweezers for 3.5 hours, and they grow aseptically after many tests. The minimum qualified concentration of the disinfectant energy test of the present invention is that the glutaraldehyde content is 2000mg / L. After the disinfectant of the present invention was used continuously for 14 day...

Embodiment 3

[0037] Add 8 grams of polyethylene glycol 6000, add 707 grams of water, heat and mix at 70°C for 1.5 hours, cool to 40°C, add 30 grams of boric acid, 15 grams of borax, and 20 grams of propyl gallate, mix for 1 hour, add alkylphenol Mix 30 grams of polyoxyethylene ether and 40 grams of sodium polyacrylate for 1 hour, add 150 grams of glutaraldehyde, and mix for 1 hour to obtain a disinfectant with a pH of 6.0.

[0038] After this embodiment disinfectant and water are diluted with 1: 9 ratio, glutaraldehyde content is 15000mg / L, and the average killing logarithmic value of effect 5hour to Bacillus subtilis var. niger spores is 3.16. It acted on the spores of Bacillus subtilis black variety stained on the tooth marks of tweezers for 8 hours, and they all grew aseptically after many times of culture. The minimum qualified concentration of the disinfectant energy test of the present invention is that the glutaraldehyde content is 2000mg / L. After the disinfectant of the present in...

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PUM

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Abstract

The invention relates to an activated glutaraldehyde disinfectant and preparation method thereof. A single component activated glutaraldehyde disinfectant includes the following components wt%: glutaraldehyde:1-20; hydrophilic polymers:1-10; nonionic surfactant:0.1-5; boric acid: 1-5; borax:0.5-5; antioxidant:0.1-3; sodium polyacrylate:0.5-5; water: excess; the pH of the said disinfectant is 5.0-7.0. According to the said content, the hydrophilic polymers are added with water and dissolved at 60-80 DEG C for 1-2 hours, then cooled to 30-50 DEG C; boric acid, borax, antioxidants are added and mixed for 0.5-1 hours; nonionic surfactant and borax are added and mixed for 0.5-1 hours; at last glutaraldehyde is added and mixed for 0.5-1 hours, the said disinfectant is obtained. The invention disinfectant has the merits of low volatilization, long storage period, easy operation, without the use of carcinogenic substances, and is always in activation state and used randomly.

Description

technical field [0001] The invention relates to a disinfectant, in particular to an activated glutaraldehyde disinfectant and a preparation method thereof. Background technique [0002] Glutaraldehyde is a new type, broad-spectrum, high-efficiency, and low-toxicity disinfectant, which can kill bacterial spores, fungal spores, mycobacteria, and viruses (including hepatitis A, hepatitis B, and HIV). After formaldehyde and ethylene oxide, it is the third milestone in the history of chemical sterilant development. Glutaraldehyde is the first-selected disinfectant recommended by the World Health Organization (WHO) for viral hepatitis, and it is also a medical disinfectant recommended by the Ministry of Health of my country. It is suitable for disinfection and sterilization of various surgical instruments, such as endoscopes, injection supplies, catheters, scalpels, etc. [0003] 2% glutaraldehyde solution is usually used for disinfection and sterilization. At present, the gluta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N59/14A01P1/00A01N25/30A01N35/02A01N43/00
Inventor 张万国黄春明张忠敏孙文胜卞雪莲
Owner SHANGHAI LIKANG DISINFECTION HIGH TECH