Heterocyclic compound capable of inversing tumor cell drug tolerance, preparation method and application thereof

Abstract

The invention discloses a heterocyclic compounds capable of reversing drug resistance of tumor cells. Preparation and usage thereof are further disclosed. The inventive heterocyclic compound has a structure indicated by formula (I). Preparation includes steps of: preparing carboline carboxylic acid by conventional process; coupling secondary amino group of carboline carboxylic acid with L-amino acid benzyl esters to generate a N position protected carboline carboxylic -L-amino acid benzyl esters after protected by protecting group; condense with acetone in methanol under catalysis of triethylamine after detraction of protecting group. It is indicated in the in vitro test, the inventive heterocyclic compound can effectively reverse drug resistance of tumor cell towards anti-tumor drug, can be used as drug resistance inhibitor of tumor cell in clinic.

Description

technical field

[0001] The present invention relates to a class of heterocyclic compounds, in particular to heterocyclic compounds capable of reversing the drug resistance of tumor cells; the present invention also relates to the preparation method of the heterocyclic compound and the application of the heterocyclic compound as an inhibitor of tumor multidrug resistance, It belongs to the field of biomedicine. Background technique

[0002] Although the clinical treatment of tumors faces many problems, such as low selectivity, poor tolerance and strong side effects of chemotherapy drugs, it is necessary to continuously find excellent anti-tumor drugs with high selectivity, good tolerance and low side effects, but the clinical The biggest challenge facing treatment is drug resistance of tumor cells, including multi-drug resistance and cross-drug resistance. The drug resistance acquired by tumor cells makes more and more excellent anti-tumor drugs lose their clinical efficacy ...

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