Kidney syndrome hemorrhagic fever mucosa immune vaccines and method of preparing the same

A technology for renal syndrome and mucosal immunity, applied in the field of vaccines, can solve the problems that mucosal immunity vaccines have not been reported yet
CN101249261BInactive Publication Date: 2010-10-27STATION OF VIRUS PREVENTION & CONTROL CHINA DISEASES PREVENTION & CONTROL CENT
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
STATION OF VIRUS PREVENTION & CONTROL CHINA DISEASES PREVENTION & CONTROL CENT
Publication Date
2010-10-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a mucosa immune vaccine of hemorrhage fever syndrome and a preparation method thereof. The vaccine comprises inactivated virus and chitosan from hantaan virus which can cause hemorrhage fever syndrome in one or a plurality of types, wherein the chitosan exists in the form of micro-particles; the inactivated virus is covered inside the micro-particles of chitosan; furthermore, the vaccine can fruther comprise escherichia coli heat-labile enterotoxin B subunit with mucosa adjuvant activity; the result of the animal experiment shows that the vaccine of the invention can effectively excite the immune response of specific mucosa and the body fluid of the body anti-hantaan virus through nasal cavity and oral administration. The vaccine has statistical significance compared with the control group (p is less than 0.01) and has the advantages of safety, convenience, cost-effeciveness etc., compared with traditional hemorrhagic fever injected vaccine.
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Description

technical field

[0001] The invention belongs to the field of vaccines, in particular to a mucosal immune vaccine against hemorrhagic fever with renal syndrome and a preparation method thereof. Background technique

[0002] Hantavirus is a segmented negative-strand RNA virus belonging to the genus Hantavirus in the family Bunyaviridae, and rodents are the main hosts of Hantavirus. According to serotype and genotype, Hantavirus can be divided into nearly 30 virus species (species). Hantavirus can cause two human diseases, namely, hemorrhagic fever with renal syndrome (Hemorrhagic Fever with Renal Syndrome, HFRS) and Hantavirus pulmonary syndrome (Hantavirus Pulmonary Syndrome, HPS). Hemorrhagic fever with renal syndrome is an acute viral infectious disease characterized by fever, bleeding tendency and kidney damage. According to international typing habits, Hantaan, Seoul, Dobrava, Puumala and other Hantaan viruses cause hemorrhagic fever with renal syndrome. Saaremaa type ...

Claims

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