Method for preparing diethylamino ethanethiol

Abstract

A preparation method of diethylamino ethanethiol comprises chlorinating diethylamino alcohol via chlorinating agent to generate diethylamino chloroethane or relative hydrochloride, reacting the diethylamino chloroethane or relative hydrochloride with thiourea to generate S-substituted isothiourea salt, and processing alkaline hydrolysis on the S-substituted isothiourea salt via strong alkali to prepare diethylamino ethanethiol. The preparation method has simple process, low cost, reduced water consumption, reduced environment pollution, high reaction activity, better directionality, high product purity and high yield (at least 80%). The invention has wide application in medicine industry.

Description

technical field The invention specifically relates to a preparation method of diethylaminoethanethiol in the technical field of medicine. Background technique Tiamulin is one of the top ten veterinary antibiotics in the world, which can be used to prevent and treat diseases caused by mycoplasma infection, E. It has special effects on endemic pneumonia, endemic pneumonia and dysentery, and is widely used in aquaculture, especially in chicken and pig aquaculture. As a key intermediate in the production of tiamulin, diethylaminoethanethiol is in great demand in pharmaceutical companies. The inventor once designed and studied following several methods to the synthesis of diethylaminoethanethiol, i.e. sulfuric acid monoester and sodium hydrosulfide method, diethylaminochloroethane and sodium hydrosulfide method, sulfuric acid monoester and thiourea method and sulfide method. The method of sulfuric acid monoester and sodium hydrosulfide is to react diethylaminoethanol and sulf...

AI Technical Summary

Problems solved by technology

The method of sulfuric acid monoester and sodium hydrosulfide is to react diethylaminoethanol and sulfuric acid to generate sulfuric acid monoester, and then react sulfuric acid monoester and sodium hydrosulfide to generate diethylaminoethanethiol. The synthesis method is easy to carry out and easy to operate. Simple, cheap and easy to get raw materials, but in industrial production, sodium hydrosulfide smells bad, more than half of the side reactions in the mercaptolation process to generate diethylaminoethanol are inevitable, and diethylaminoethanethiol and diethylaminoethanol The boiling points are equal, and the products are difficult to separate

The diethylaminochloroethane and sodium hydrosulfide method is to obtain the diethylaminoethanol product by reacting diethylaminochloroethane and high-concentration sodium hydrosulfide to obtain the diethylaminoethanol product, but this synthetic method also has the similarity with the above-mentioned method Disadvantages, that is, the odor is unpleasant during industrial production, the reaction orientation is poor, and the reaction products are difficult to separate, etc.

The above-mentioned methods are not suitable for industrial applications, and consume a large amount of organic solvents or water resources

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