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Gargle preparations containing diastatin nystatin

A technology for nystatin and preparations, which is applied to medical preparations containing active ingredients, topical antibacterial agents, organic active ingredients, etc., can solve the problems of poor bioavailability and poor effect of nystatin, and achieve less side effects and better taste. The effect of good and good medical prospects

Inactive Publication Date: 2008-09-03
BEIJING CENTURY BIOCOM PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Nystatin is less effective against mucosal fungal infections, especially oral mucosal fungal infections, due to its poor bioavailability

Method used

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  • Gargle preparations containing diastatin nystatin

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0017] Nystatin 500,000 units

[0018] Crystalline Cellulose 15mg

[0019] Lactose 47mg

[0020] Pregelatinized starch 20mg

[0021] Crospovidone 40mg

[0022] Micronized silica gel 1.7mg

[0023] Preparation:

[0024] Weigh the raw and auxiliary materials in the prescription one by one according to the proportion of the prescription, and mix them according to the method of equal addition. Measure the content of nystatin in the mixed material, adjust the weight of the tablet according to the test result of the semi-finished product, and press the tablet.

[0025] According to the appendix X A method of "Chinese Pharmacopoeia 2005 edition (two)", the disintegration time is less than 15 minutes.

preparation Embodiment 2

[0027] Nystatin 500,000 units

[0028] Crystalline Cellulose 20mg

[0029] Lactose 70mg

[0030] Pregelatinized starch 12mg

[0031] Crospovidone 160mg

[0032] Micronized silica gel 2.0mg

[0033] Preparation:

[0034] Weigh the raw and auxiliary materials in the prescription one by one according to the proportion of the prescription, and mix them according to the method of equal addition. Measure the content of nystatin in the mixed material, adjust the weight of the tablet according to the test result of the semi-finished product, and press the tablet.

[0035] According to the appendix X A method of "Chinese Pharmacopoeia 2005 edition (two)", the disintegration time is less than 15 minutes.

preparation Embodiment 3

[0037] Nystatin 500,000 units

[0038] Menthol 10mg

[0039] Crystalline Cellulose 20mg

[0040] Lactose 75mg

[0041] Pregelatinized starch 30mg

[0042] Crospovidone 30mg

[0043] Micronized silica gel 1.7mg

[0044] Preparation:

[0045] Weigh the raw and auxiliary materials in the prescription one by one according to the proportion of the prescription, and mix them according to the method of equal addition. Measure the content of nystatin in the mixed material, adjust the weight of the tablet according to the test result of the semi-finished product, and press the tablet.

[0046] According to the appendix X A method of "Chinese Pharmacopoeia 2005 edition (two)", the disintegration time is less than 15 minutes.

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Abstract

The invention relates to a nysfungin mouthwash preparation for oral application and uses thereof. The nysfungin mouthwash preparation is prepared from nysfungin serving as an active ingredient and aromatic synergistic agents with synergetic effect can be added to the preparation. The mouthwash preparation is available in the form of mouthwash tablet, effervescent tablet, dispersible tablet, granule or buccal tablet. The inventive nysfungin mouthwash preparation can be used for preventing and treating oral fungal infections; and has the advantages of good therapeutic effect, low side effects, low irritation, and good medical prospect.

Description

technical field [0001] The invention relates to a solid preparation containing nystatin for treating oral candida infection, in particular to an oral preparation for gargling. Background technique [0002] Nystatin (Fungicidin, Nysfafin, Nystatin) (about 100 mg per 500,000 unit weight) is a polyene antifungal antibiotic, which has a strong effect on most deep and superficial infection fungi, and has a strong effect on various fungi such as Candida albicans Bacteria, Cryptococcus, Capsular Histoplasma, Coccidioides, etc. have inhibitory effects. Nystatin has antibacterial and bactericidal effects. Its mechanism of action is mainly to change the permeability of the cell membrane, combine with the plasma membrane, remove potassium ions and other components in the cell, and inhibit its growth. It has a significant effect on Candida, such as gastrointestinal candidiasis, oral thrush, candidal vaginitis, vulvitis, etc. It is mainly used clinically for Candida infections of the ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/047A61K47/10A61P1/02A61P31/02
Inventor 郝守祝
Owner BEIJING CENTURY BIOCOM PHARMA TECH
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