Amphipathic three block copolymer and its preparation method and application
A triblock and copolymer technology, which is used in pharmaceutical formulations, medical preparations with inactive ingredients, etc.
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Embodiment 1
[0019] Add 0.01 g of potassium hydride into the polymerization reactor, weigh 0.4986 g of polyethylene glycol monomethyl ether with a relative molecular mass of 2000 according to the requirements of the equivalent substance mass, and prepare it into a tetrahydrofuran solution and inject it into the polymerization reactor. React at 25°C for 2 hours; inject 1.4959g of lactide into the polymerization reactor, inject 0.4986g of methacrylic acid-N,N-dimethylaminoethyl ester after 2 hours of reaction, continue the reaction for 2 hours, add degassed methanol to terminate the reaction ; Precipitate and purify the triblock copolymer dissolved in tetrahydrofuran with a large amount of n-hexane at 0°C, repeat the precipitation three times, and then dry it in a vacuum oven at 40°C to obtain a compound with good biocompatibility, biodegradability and pH sensitive cationic amphiphilic triblock copolymer.
[0020] The amphiphilic tri-block copolymer prepared in this example self-assembled in...
Embodiment 2
[0022] Add 0.1 g of potassium hydride into the polymerization reactor, weigh 4.9863 g of polyethylene glycol monomethyl ether with a relative molecular mass of 2000 according to the requirements of the equivalent substance mass, and prepare it into a tetrahydrofuran solution and inject it into the polymerization reactor. React at 25°C for 2 hours; inject 1.0685g of lactide into the polymerization reactor, inject 1.0685g of methacrylic acid-N,N-dimethylaminoethyl ester after 2 hours of reaction, continue the reaction for 2 hours, add degassed methanol to terminate the reaction ; Precipitate and purify the triblock copolymer dissolved in tetrahydrofuran with a large amount of n-hexane at 0°C, repeat the precipitation three times, and then dry it in a vacuum oven at 40°C to obtain a compound with good biocompatibility, biodegradability and pH sensitive cationic amphiphilic triblock copolymer.
Embodiment 3
[0024] Add 0.05 g of potassium hydride into the polymerization reactor, weigh 2.4931 g of polyethylene glycol monomethyl ether with a relative molecular mass of 2000 according to the requirements of the equivalent substance mass, and prepare it into a tetrahydrofuran solution and inject it into the polymerization reactor. React at 25°C for 2 hours; inject 3.4281g of lactide into the polymerization reactor, inject 0.3116g of methacrylic acid-N,N-dimethylaminoethyl ester after 2 hours of reaction, continue the reaction for 2 hours, add degassed methanol to terminate the reaction ; Precipitate and purify the triblock copolymer dissolved in tetrahydrofuran with a large amount of n-hexane at 0°C, repeat the precipitation three times, and then dry it in a vacuum oven at 40°C to obtain a compound with good biocompatibility, biodegradability and pH sensitive cationic amphiphilic triblock copolymer.
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