Tea pigment sustained-release dropping pills and method of preparing the same

A technology of slow-release dripping pills and tea pigments, which is applied in the direction of pharmaceutical formulas, medical preparations with no active ingredients, and medical preparations containing active ingredients. Improvement and other issues, to achieve the effect of accelerated dissolution and absorption, improved bioavailability, and increased total surface area

Inactive Publication Date: 2008-10-01
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have long dissolution time, low dissolution rate, poor absorption, many times of taking medicine, hepatic and intestinal first-pass effect and bioavailability after taking. Lower problems, which affect the efficacy of the drug, also directly affect the therapeutic effect
[0014] In addition, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0042] Now with several groups of specific examples, the preparation method of the tea pigment sustained-release dropping pills of the present invention will be further described.

[0043] First group:

[0044] Based on the total weight of 100g, weigh 20% of the matrix PEG1500, 10% of PEG6000, 30% of PEG4000, 15% of stearic acid, 5% of glyceryl monostearate, and 20% of the raw material tea pigment dry extract; Heat and stir in the container to make it melt, add the corresponding proportion of tea pigment dry extract, stir well to make it melt or mix, and under the condition of heat preservation, drop the melted or mixed medicine solution into the simethicone In the condensate column, the temperature when heating and melting is 55°C, the temperature of the upper part of the condensate is 30°C, and the temperature of the bottom is -4°C; take it out after forming.

[0045] The obtained product has a 2-hour cumulative release percentage of 32-53%, a 6-hour cumulative release perc...

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PUM

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Abstract

The invention relates to a pharmaceutical composition which has the functions of refreshing mind, resolving phlegm and eliminating fat and is applied to treating dizzying, chest distress, chest pain, hyperlipidemia, coronary heart disease, angina, cerebral infarction and other similar symptoms caused by intermingled phlegm and blood stasis. The pharmaceutical composition of the invention aims at compensating for the shortage of tea pigment oral preparations and providing an oral preparation tea pigment sustained-release dropping pill of the pharmaceutical composition which can make effect quickly, has high bioavailability, long effective time, few medicine taking times, less toxicity and side effects, high drug contents, little and accurate dose, convenient use, low cost and easy carrying.

Description

technical field [0001] The present invention relates to a medicine that has the functions of clearing head, reducing phlegm and reducing fat, and is used for treating head dizziness, chest tightness and chest pain, hyperlipidemia, coronary heart disease, angina pectoris, cerebral infarction and other symptoms caused by phlegm and blood stasis. Release pharmaceutical composition-tea pigment sustained-release dropping pills and a preparation method thereof, which belong to the technical field of pharmacy. Background technique [0002] Thea pigment is a compound extracted from tea leaves. There is no clear description of the specific structural formula of thea pigment. It is generally believed that thea pigment is a mixture composed of theaflavins, thearubigins and theabrownins, mainly A mixture of tea polyphenols produced after oxidation. [0003] According to the national drug standard WS 3 -The tea pigment capsule prepared according to the formula and preparation process g...

Claims

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Application Information

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IPC IPC(8): A61K36/82A61K9/22A61K47/34A61K47/38A61P3/06A61P9/10A61K31/352A61K47/10
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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