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Noble metal/phenolic resin biocompatible material having core-shell structure and preparation thereof

A technology of biocompatibility and core-shell structure, applied in the field of preparation of precious metal/phenolic resin core-shell structure, can solve the problems of no biological fluorescent material research, single magnetic properties, weakening of fluorescence properties, etc. Large-scale production, time-durable fluorescent properties, effects of short reaction times

Inactive Publication Date: 2010-12-22
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Germany "Advanced Materials" (Advanced Materials, 2006 18 issue 2553 pages) reported polyethylene glycol (PEG) modified Fe 3 o 4 Nanoparticles can be used for cancer detection. This detection method based on magnetic resonance imaging (MRI) technology provides a platform for the development of nanomagnetic particles; however, because it only has a single magnetic property, and the functional groups on the surface of PEG The single limit of its detection of many different cancer cells
[0008] Fe 3 o 4 / SiO 2 The core-shell structure, the fuel molecules are coated in SiO 2 The dual functions of fluorescence and magnetism can be realized in it, so that it can be applied in the identification of tumor cells and the delivery of drugs; however, because the fluorescent material used in it is a fluorescent molecule, the fluorescent properties of this material will weaken a lot with time.
[0009] Cured phenolic resin is an important polymer material, which has important uses in the fields of electronics, electrical appliances, building materials, national defense, etc. However, there has been no relevant report on its use as a bioluminescence material so far.

Method used

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  • Noble metal/phenolic resin biocompatible material having core-shell structure and preparation thereof
  • Noble metal/phenolic resin biocompatible material having core-shell structure and preparation thereof
  • Noble metal/phenolic resin biocompatible material having core-shell structure and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] First mix 10ml 0.1mol / L phenol and 5ml 0.5mol / L hexamethylenetetramine aqueous solution, then add 1ml 10 -3 -10 -5 mol / L silver nitrate solution, add water to a total volume of 22ml, seal the above solution in a reaction vessel, react at 180°C for 4 hours, wash the product three times with water and ethanol to remove impurities respectively, and obtain silver / phenolic resin partial Particles with a core structure, the particle size is 1000nm.

[0029] Weigh 0.02g silver / phenolic resin partial core-shell particles and place them in 10ml benzyl alcohol, ultrasonically disperse them evenly, then add 0.2mmol Fe(acac) 3 , heated to 200°C for 3 minutes, and kept at a constant temperature for 5 minutes to obtain Fe 3 o 4 Coated Silver / Phenolic / Fe 3 o 4 particles with a three-layer core-shell structure.

[0030] Weigh 0.02g of silver / phenolic resin particles with partial core-shell structure and place them in 20ml of water, ultrasonically disperse them evenly, then add 0....

Embodiment 2

[0039] First mix 5ml 0.1mol / L phenol and 10ml 0.5mol / L hexamethylenetetramine aqueous solution, then add 0.1ml 10 -3 -10 -5 mol / L silver nitrate solution, add water to a total volume of 22ml, seal the above solution in a reaction vessel, react at 180°C for 4 hours, wash the product three times with water and ethanol to remove impurities respectively, and obtain silver / phenolic resin partial Nanoparticles with a core structure, the particle size is 500nm.

[0040] Weigh 0.01g silver / phenolic resin partial nucleus structure nanoparticles and put them in 10ml benzyl alcohol, ultrasonically disperse them evenly, then add 0.2mmol Fe(acac) 3 , heated to 200°C for 3 minutes, and kept at a constant temperature for 5 minutes to obtain Fe 3 o 4 Coated Silver / Phenolic / Fe 3 o 4 particles with a three-layer core-shell structure.

[0041] Weigh 0.02g silver / phenolic resin partial nucleus structure nanoparticles and put them in 20ml water, ultrasonically disperse them evenly, then add ...

Embodiment 3

[0051] First mix 5ml 0.1mol / L phenol and 5ml 0.5mol / L hexamethylenetetramine aqueous solution, then add 0.1ml 10 -3 -10 -5 mol / L silver nitrate solution, add water to a total volume of 22ml, seal the above solution in a reaction vessel, react at 180°C for 4 hours, wash the product three times with water and ethanol to remove impurities respectively, and obtain silver / phenolic resin positive Nanoparticles with a core structure, the particle size is 500nm.

[0052] Weigh 0.02g silver / phenolic resin positive core-shell nanoparticles and place them in 20ml distilled water, ultrasonically disperse them evenly, then add 0.2mmol FeSO 4 , 0.1mmol of hexamethylenetetramine, heated to 200°C for 5 minutes, and kept at constant temperature for 5 minutes to obtain Fe 3 o 4 Coated Silver / Phenolic / Fe 3 o 4 three-layer core-shell structure particles.

[0053] Weigh 0.02g silver / phenolic resin positive core-shell nanoparticles and place them in 20ml water, ultrasonically disperse them ev...

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Abstract

The invention discloses a precious metal / phenolic resin core-shell structure biocompatible material and the preparation method and is characterized in that phenol, hexamethylenetetramine and the salt solution of precious metal are reacted for 2 to 10 hours at 120 to 180 DEG C so as to obtain a core-shell structure particle; and then the core-shell structure particle is used as the carrier and reacted for 5min-10h at 160-200 DEG C through the method of synthesizing magnetic nano-Fe3O4 to synthesize a three-tier core-shell structure particle containing Fe3O4 modified precious metal / phenolic resin / Fe3O4, or synthesize a four-tier core-shell structure material particle containing gold nano-particle modified precious metal / phenolic resin / Fe3O4 / Au. The material has fluorescent and magnetic dualfunctions and has good application prospect in biological fluorescence imaging or magnetic resonance imaging technology in living biological organisms or cells. The preparation method of the invention can easily obtain the raw materials and has simple technology and easy operation, which is suitable for industrialization amplification.

Description

technical field [0001] The invention belongs to the technical field of nanometer material preparation, and relates to a method for preparing fluorescent nanometer material with biocompatibility, especially a noble metal / phenolic resin core-shell structure. Background technique [0002] At present, the following reports on the one-step synthesis of core-shell nanostructures can be seen: [0003] "Journal of the American Chemical Society" (Journal of the American Chemical Society, 2005, 127, page 2822) reported a method for synthesizing nanocables in one step. Shell structure; however, due to the long reaction time and the cross-linked core-shell structure of the product, further utilization of the product is difficult. [0004] British "Chemical Communication" (Chemical Communication, 2006, page 1622) reported the preparation of SiO 2 / polyaniline core-shell structure method, this method is based on SiO 2 As the core, the negative charge on its surface interacts with the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L61/06C08K3/28C08J7/12C08J3/28C09K11/06H01F1/42
Inventor 俞书宏郭仕锐
Owner UNIV OF SCI & TECH OF CHINA
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