Uses of Petasites tricholobus franch extract in medicament preparation for preventing and controlling cardiovascular and cerebrovascular diseases

A technique for cardiovascular and cerebrovascular diseases and trichomonas, applied in the field of medicine

CN101297828AActive Publication Date: 2008-11-05SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY

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Patent Information

Authority / Receiving Office: CN · China
Current Assignee / Owner: SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Publication Date: 2008-11-05

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Abstract

The invention relates to the field of medical technology, which discloses a new usage of a petasites tricholobus franch extract and the contained bakkenolide compound in the preparation of drugs for prevention and treatment for cardiovascular and cerebrovascular diseases. The biological activity tests show that, the petasites tricholobus franch extract and the contained bakkenolide compound can significantly reduce the encephalic necrosis percentage of the rats with local cerebral ischemia, improve the behavior score of the ischemic rats and alleviate volume of brain edema and cerebral infarction of the rats with ischemia reperfusion injury, thus prompting that the petasites tricholobus franch extract and the contained bakkenolide compound have significant protective effect on the cerebral ischemia injury. The petasites tricholobus franch extract and the contained bakkenolide compound can further significantly reduce the J-point displacement caused by ISO and the LDH level in plasma, significantly reduce the scope of myocardial ischemic myocardial infarction of the rats caused by coronary artery ligation and lower the LDH level in the plasma of the rats with the myocardial ischemia. As the petasites tricholobus franch extract and the contained bakkenolide compound have good effects on the prevention and the treatment for heart and brain ischemic diseases aspects, the petasitestricholobus franch extract and the contained bakkenolide compound can be used in the preparation of drugs for prevention and treatment for cardiovascular and cerebrovascular diseases, including coronary heart disease, cerebral ischemia, cerebral infarction (stroke), myocardial infarction and so on.

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Description

technical field

[0001] The invention relates to the technical field of medicine, and relates to a new application of butterbur extract and butterbur lactone compounds contained therein in the preparation of drugs for preventing and treating cardiovascular and cerebrovascular diseases. Background technique

[0002] Petasites tricholobus Franch. belongs to the genus Petasites tricholobus Franch. Its rhizomes are used in the folk for detoxification and blood stasis, and for external application to treat bruises, fractures and snakebites. In order to develop and utilize the plant, the present inventor has carried out systematic chemical composition and pharmacological research on the plant, and has used four new butterbur lactone compounds and butterbur lactone compounds in Butterbur pilaris. Applied for a patent (patent publication number: CN1844114) for the treatment of diseases that may be related to histamine and / or leukotrienes, and applied for the extract of Butterbur pila...

Claims

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